ID   AAXC_CHLAB              Reviewed;         486 AA.
AC   Q5L5E6;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   21-JUN-2005, sequence version 1.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD; OrderedLocusNames=CAB698;
OS   Chlamydia abortus (strain DSM 27085 / S26/3) (Chlamydophila abortus).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=218497;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 27085 / S26/3;
RX   PubMed=15837807; DOI=10.1101/gr.3684805;
RA   Thomson N.R., Yeats C., Bell K., Holden M.T.G., Bentley S.D.,
RA   Livingstone M., Cerdeno-Tarraga A.-M., Harris B., Doggett J., Ormond D.,
RA   Mungall K., Clarke K., Feltwell T., Hance Z., Sanders M., Quail M.A.,
RA   Price C., Barrell B.G., Parkhill J., Longbottom D.;
RT   "The Chlamydophila abortus genome sequence reveals an array of variable
RT   proteins that contribute to interspecies variation.";
RL   Genome Res. 15:629-640(2005).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; CR848038; CAH64145.1; -; Genomic_DNA.
DR   RefSeq; WP_011097273.1; NC_004552.2.
DR   AlphaFoldDB; Q5L5E6; -.
DR   SMR; Q5L5E6; -.
DR   EnsemblBacteria; CAH64145; CAH64145; CAB698.
DR   KEGG; cab:CAB698; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_007946_1_2_0; -.
DR   OMA; FNSDNRV; -.
DR   OrthoDB; 527053at2; -.
DR   Proteomes; UP000001012; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..486
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363173"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        132..152
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  52473 MW;  F894749325E2D431 CRC64;
     MISNGSKSGK NLGAIALAGM VISSMIGGGI FSLPQNMAAS AGVGAIILAW ILTGVGMFFI
     ANTFKILSLV RPDLTTGIYM YSREGFGPYI GFTIGWGYWL CQIFGNVGYA VMTMDALNYF
     FPPYFQGGNT LPAILGGSIL IWVFNFIVLK GIRQASFINI IGTVGKLVPL IVFIIITAFL
     FKLAIFKTDF WGDTVTKTQP LLGSMTSQLK STMLVTLWAF IGIEGAVVMS ARAKSPSAVG
     KATILGFTGC LTVYILLSIL PFGSLFQHQL AGIANPSTAG VLDILVGKWG EILMNVGLLI
     AVLSSWLSWT MIVAEIPYSA AKNGTFPEIF AIENAHRSPK VSLYVTSALM QIAMLLVYFS
     TDAWNTMLSI TGVMVLPAYF ASAAFLVKFS KNKKYPNKGP IKAFTAKITG LLGAVYSIWL
     IYAGGLKYLL MAIILLALGI PFYIDAGKKG RNAKTFFAKK EVTEITIIAF LALLAIFLFS
     TEKIRL