ID   RL7A_CAEEL              Reviewed;         265 AA.
AC   Q966C6; Q8T875;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 139.
DE   RecName: Full=60S ribosomal protein L7a;
GN   Name=rpl-7A {ECO:0000312|WormBase:Y24D9A.4a};
GN   ORFNames=Y24D9A.4 {ECO:0000312|WormBase:Y24D9A.4a};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
RN   [2] {ECO:0000305}
RP   PROTEIN SEQUENCE OF 39-49; 86-94; 103-111; 178-186; 189-196; 198-213 AND
RP   219-230, AND IDENTIFICATION BY MASS SPECTROMETRY.
RA   Bienvenut W.V.;
RL   Submitted (SEP-2005) to UniProtKB.
RN   [3]
RP   INTERACTION WITH CMD-1.
RX   PubMed=17854888; DOI=10.1016/j.ceca.2007.07.008;
RA   Shen X., Valencia C.A., Gao W., Cotten S.W., Dong B., Huang B.C., Liu R.;
RT   "Ca(2+)/Calmodulin-binding proteins from the C. elegans proteome.";
RL   Cell Calcium 43:444-456(2008).
CC   -!- SUBUNIT: Interacts with cmd-1 in the presence of Ca(2+).
CC       {ECO:0000269|PubMed:17854888}.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=a {ECO:0000312|WormBase:Y24D9A.4a};
CC         IsoId=Q966C6-1; Sequence=Displayed;
CC       Name=c {ECO:0000312|WormBase:Y24D9A.4c};
CC         IsoId=Q966C6-2; Sequence=VSP_051845;
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC       {ECO:0000255}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BX284604; CCD71898.1; -; Genomic_DNA.
DR   EMBL; BX284604; CCD71899.1; -; Genomic_DNA.
DR   RefSeq; NP_741371.2; NM_171316.6. [Q966C6-1]
DR   RefSeq; NP_741372.2; NM_171904.4.
DR   AlphaFoldDB; Q966C6; -.
DR   SMR; Q966C6; -.
DR   BioGRID; 42335; 91.
DR   DIP; DIP-25472N; -.
DR   STRING; 6239.Y24D9A.4a; -.
DR   EPD; Q966C6; -.
DR   PaxDb; Q966C6; -.
DR   PeptideAtlas; Q966C6; -.
DR   EnsemblMetazoa; Y24D9A.4.1; Y24D9A.4.1; WBGene00004419. [Q966C6-1]
DR   GeneID; 177203; -.
DR   KEGG; cel:CELE_Y24D9A.4; -.
DR   UCSC; Y24D9A.4a; c. elegans. [Q966C6-1]
DR   CTD; 177203; -.
DR   WormBase; Y24D9A.4a; CE27398; WBGene00004419; rpl-7A. [Q966C6-1]
DR   WormBase; Y24D9A.4c; CE30401; WBGene00004419; rpl-7A. [Q966C6-2]
DR   eggNOG; KOG3166; Eukaryota.
DR   GeneTree; ENSGT00940000170054; -.
DR   InParanoid; Q966C6; -.
DR   OMA; WLPALCK; -.
DR   OrthoDB; 1200503at2759; -.
DR   PhylomeDB; Q966C6; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q966C6; -.
DR   Proteomes; UP000001940; Chromosome IV.
DR   Bgee; WBGene00004419; Expressed in larva and 3 other tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0005516; F:calmodulin binding; IPI:WormBase.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   InterPro; IPR029064; L30e-like.
DR   InterPro; IPR001921; Ribosomal_L7A/L8.
DR   InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR   InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR   InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR   Pfam; PF01248; Ribosomal_L7Ae; 1.
DR   PRINTS; PR00881; L7ARS6FAMILY.
DR   PRINTS; PR00882; RIBOSOMALL7A.
DR   SUPFAM; SSF55315; SSF55315; 1.
DR   PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE   1: Evidence at protein level;
KW   Alternative splicing; Calmodulin-binding; Direct protein sequencing;
KW   Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..265
FT                   /note="60S ribosomal protein L7a"
FT                   /id="PRO_0000136756"
FT   VAR_SEQ         109..128
FT                   /note="Missing (in isoform c)"
FT                   /evidence="ECO:0000305"
FT                   /id="VSP_051845"
SQ   SEQUENCE   265 AA;  30174 MW;  AC44C4420295D932 CRC64;
     MPSKKVIKKK VAAVPAHIRA QTQVQKEVKN PLFEKRARNF NIGQDIQPKK DVTRFVKWPK
     YIRLQRQSAI LQKRLKVPPT INQFRTALDS QSARQAFKLL DKYRPESTEA KKNRLRARAE
     ARAAGKKEEV TKRPNTVRHG VNTITRLVET RRAQLVLIAH DVNPLEIVLH LPALCRKYNV
     PYAIIKGKAS LGTVVRRKTT AAVALVDVNP EDKSALNKLV ETVNNNFSER HEEIRKHWGG
     GVMSAKSDAK KLKIERARAR DLGKL