RL7A_DROME
ID RL7A_DROME Reviewed; 271 AA.
AC P46223; A4V411; Q9W3Z2;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 27-SEP-2005, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=60S ribosomal protein L7a;
GN Name=RpL7A; Synonyms=SURF-3; ORFNames=CG3314;
OS Drosophila melanogaster (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=7227;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Canton-S;
RX PubMed=7739520; DOI=10.1128/mcb.15.5.2367;
RA Armes N., Fried M.;
RT "The genomic organization of the region containing the Drosophila
RT melanogaster rpL7a (Surf-3) gene differs from those of the mammalian and
RT avian Surfeit loci.";
RL Mol. Cell. Biol. 15:2367-2373(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Berkeley;
RX PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X., Brandon R.C.,
RA Rogers Y.-H.C., Blazej R.G., Champe M., Pfeiffer B.D., Wan K.H., Doyle C.,
RA Baxter E.G., Helt G., Nelson C.R., Miklos G.L.G., Abril J.F., Agbayani A.,
RA An H.-J., Andrews-Pfannkoch C., Baldwin D., Ballew R.M., Basu A.,
RA Baxendale J., Bayraktaroglu L., Beasley E.M., Beeson K.Y., Benos P.V.,
RA Berman B.P., Bhandari D., Bolshakov S., Borkova D., Botchan M.R., Bouck J.,
RA Brokstein P., Brottier P., Burtis K.C., Busam D.A., Butler H., Cadieu E.,
RA Center A., Chandra I., Cherry J.M., Cawley S., Dahlke C., Davenport L.B.,
RA Davies P., de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I.,
RA Dietz S.M., Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C.,
RA Dunn P., Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S.,
RA Fleischmann W., Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M.,
RA Glasser K., Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA Harris N.L., Harvey D.A., Heiman T.J., Hernandez J.R., Houck J., Hostin D.,
RA Houston K.A., Howland T.J., Wei M.-H., Ibegwam C., Jalali M., Kalush F.,
RA Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A., Kimmel B.E., Kodira C.D.,
RA Kraft C.L., Kravitz S., Kulp D., Lai Z., Lasko P., Lei Y., Levitsky A.A.,
RA Li J.H., Li Z., Liang Y., Lin X., Liu X., Mattei B., McIntosh T.C.,
RA McLeod M.P., McPherson D., Merkulov G., Milshina N.V., Mobarry C.,
RA Morris J., Moshrefi A., Mount S.M., Moy M., Murphy B., Murphy L.,
RA Muzny D.M., Nelson D.L., Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R.,
RA Pacleb J.M., Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V.,
RA Reese M.G., Reinert K., Remington K., Saunders R.D.C., Scheeler F.,
RA Shen H., Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.J.,
RA Spier E., Spradling A.C., Stapleton M., Strong R., Sun E., Svirskas R.,
RA Tector C., Turner R., Venter E., Wang A.H., Wang X., Wang Z.-Y.,
RA Wassarman D.A., Weinstock G.M., Weissenbach J., Williams S.M., Woodage T.,
RA Worley K.C., Wu D., Yang S., Yao Q.A., Ye J., Yeh R.-F., Zaveri J.S.,
RA Zhan M., Zhang G., Zhao Q., Zheng L., Zheng X.H., Zhong F.N., Zhong W.,
RA Zhou X., Zhu S.C., Zhu X., Smith H.O., Gibbs R.A., Myers E.W., Rubin G.M.,
RA Venter J.C.;
RT "The genome sequence of Drosophila melanogaster.";
RL Science 287:2185-2195(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=Berkeley;
RX PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA Smith C.D., Tupy J.L., Whitfield E.J., Bayraktaroglu L., Berman B.P.,
RA Bettencourt B.R., Celniker S.E., de Grey A.D.N.J., Drysdale R.A.,
RA Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q., Stapleton M.,
RA Yamada C., Ashburner M., Gelbart W.M., Rubin G.M., Lewis S.E.;
RT "Annotation of the Drosophila melanogaster euchromatic genome: a systematic
RT review.";
RL Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Berkeley; TISSUE=Embryo;
RX PubMed=12537569; DOI=10.1186/gb-2002-3-12-research0080;
RA Stapleton M., Carlson J.W., Brokstein P., Yu C., Champe M., George R.A.,
RA Guarin H., Kronmiller B., Pacleb J.M., Park S., Wan K.H., Rubin G.M.,
RA Celniker S.E.;
RT "A Drosophila full-length cDNA resource.";
RL Genome Biol. 3:RESEARCH0080.1-RESEARCH0080.8(2002).
RN [5]
RP STRUCTURE BY ELECTRON MICROSCOPY (6.0 ANGSTROMS) OF THE 80S RIBOSOME.
RX PubMed=23636399; DOI=10.1038/nature12104;
RA Anger A.M., Armache J.P., Berninghausen O., Habeck M., Subklewe M.,
RA Wilson D.N., Beckmann R.;
RT "Structures of the human and Drosophila 80S ribosome.";
RL Nature 497:80-85(2013).
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000305}.
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DR EMBL; X82782; CAA58023.1; -; Genomic_DNA.
DR EMBL; AE014298; AAF46169.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09170.1; -; Genomic_DNA.
DR EMBL; AE014298; AAN09172.1; -; Genomic_DNA.
DR EMBL; AY089570; AAL90308.1; -; mRNA.
DR PIR; A57416; A57416.
DR RefSeq; NP_001284944.1; NM_001298015.1.
DR RefSeq; NP_001284945.1; NM_001298016.1.
DR RefSeq; NP_511063.1; NM_078508.6.
DR RefSeq; NP_727094.1; NM_167073.3.
DR RefSeq; NP_727096.1; NM_167075.2.
DR PDB; 4V6W; EM; 6.00 A; CG=1-271.
DR PDB; 6XU6; EM; 3.50 A; CG=31-271.
DR PDB; 6XU7; EM; 4.90 A; CG=31-271.
DR PDB; 6XU8; EM; 3.00 A; CG=31-271.
DR PDBsum; 4V6W; -.
DR PDBsum; 6XU6; -.
DR PDBsum; 6XU7; -.
DR PDBsum; 6XU8; -.
DR AlphaFoldDB; P46223; -.
DR SMR; P46223; -.
DR BioGRID; 58075; 125.
DR IntAct; P46223; 2.
DR MINT; P46223; -.
DR STRING; 7227.FBpp0070877; -.
DR PaxDb; P46223; -.
DR PRIDE; P46223; -.
DR DNASU; 31588; -.
DR EnsemblMetazoa; FBtr0070915; FBpp0070877; FBgn0014026.
DR EnsemblMetazoa; FBtr0070916; FBpp0070878; FBgn0014026.
DR EnsemblMetazoa; FBtr0343328; FBpp0309986; FBgn0014026.
DR EnsemblMetazoa; FBtr0343329; FBpp0309987; FBgn0014026.
DR EnsemblMetazoa; FBtr0345293; FBpp0311460; FBgn0014026.
DR GeneID; 31588; -.
DR KEGG; dme:Dmel_CG3314; -.
DR CTD; 6130; -.
DR FlyBase; FBgn0014026; RpL7A.
DR VEuPathDB; VectorBase:FBgn0014026; -.
DR eggNOG; KOG3166; Eukaryota.
DR HOGENOM; CLU_055193_0_1_1; -.
DR InParanoid; P46223; -.
DR OMA; WLPALCK; -.
DR OrthoDB; 1200503at2759; -.
DR PhylomeDB; P46223; -.
DR Reactome; R-DME-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DME-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DME-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DME-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DME-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DME-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR SignaLink; P46223; -.
DR BioGRID-ORCS; 31588; 1 hit in 1 CRISPR screen.
DR ChiTaRS; RpL7A; fly.
DR GenomeRNAi; 31588; -.
DR PRO; PR:P46223; -.
DR Proteomes; UP000000803; Chromosome X.
DR Bgee; FBgn0014026; Expressed in seminal fluid secreting gland and 12 other tissues.
DR ExpressionAtlas; P46223; baseline and differential.
DR Genevisible; P46223; DM.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0022626; C:cytosolic ribosome; IDA:FlyBase.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IDA:FlyBase.
DR GO; GO:0002181; P:cytoplasmic translation; TAS:FlyBase.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR001921; Ribosomal_L7A/L8.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00882; RIBOSOMALL7A.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..271
FT /note="60S ribosomal protein L7a"
FT /id="PRO_0000136755"
FT CONFLICT 112
FT /note="P -> A (in Ref. 1; CAA58023)"
FT /evidence="ECO:0000305"
FT CONFLICT 116..117
FT /note="KL -> NV (in Ref. 1; CAA58023)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 271 AA; 30732 MW; A31E9735E891E479 CRC64;
MVVKKPRPKK KPVTKKVAPA PLAVKKPVVK KVVNQLFEKR PKNFGIGQNV QPKRDLSRFV
RWPKYIRVQR QKAVLQKRLK VPPPIHQFSQ TLDKTTAVKL FKLLEKYRPE SPLAKKLRLK
KIAEAKAKGK DVEPKKKPSY VSAGTNTVTK LIEQKKAQLV VIAHDVDPLE LVLFLPALCR
KMGVPYCIVK GKARLGRLVR RKTCTTLALT TVDNNDKANF GKVLEAVKTN FNERHEEIRR
HWGGGILGSK SLARISKLER AKARELAQKQ G
