RL7A_RAT
ID RL7A_RAT Reviewed; 266 AA.
AC P62425; P11518;
DT 05-JUL-2004, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 2.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=60S ribosomal protein L7a;
GN Name=Rpl7a;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RX PubMed=2748341;
RA Nakamura H., Tanaka T., Ishikawa K.;
RT "Nucleotide sequence of cloned cDNA specific for rat ribosomal protein
RT L7a.";
RL Nucleic Acids Res. 17:4875-4875(1989).
RN [2]
RP PROTEIN SEQUENCE OF 2-40.
RX PubMed=398910; DOI=10.1002/jss.400120403;
RA Wittmann-Liebold B., Geissler A.W., Lin A., Wool I.G.;
RT "Sequence of the amino-terminal region of rat liver ribosomal proteins S4,
RT S6, S8, L6, L7a, L18, L27, L30, L37, L37a, and L39.";
RL J. Supramol. Struct. 12:425-433(1979).
CC -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC large ribonucleoprotein complex responsible for the synthesis of
CC proteins in the cell. {ECO:0000250|UniProtKB:P62424}.
CC -!- SUBUNIT: Component of the large ribosomal subunit (By similarity).
CC Interacts with CRY1 (By similarity). Interacts with DICER1, AGO2,
CC TARBP2, MOV10 and EIF6; they form a large RNA-induced silencing complex
CC (RISC) (By similarity). {ECO:0000250|UniProtKB:P12970,
CC ECO:0000250|UniProtKB:P62424}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P62424}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000305}.
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DR EMBL; X15013; CAA33117.1; -; mRNA.
DR PIR; S04712; R5RT7A.
DR RefSeq; NP_001107863.1; NM_001114391.1.
DR AlphaFoldDB; P62425; -.
DR SMR; P62425; -.
DR BioGRID; 255414; 4.
DR IntAct; P62425; 6.
DR MINT; P62425; -.
DR STRING; 10116.ENSRNOP00000006754; -.
DR iPTMnet; P62425; -.
DR PhosphoSitePlus; P62425; -.
DR jPOST; P62425; -.
DR PaxDb; P62425; -.
DR PRIDE; P62425; -.
DR Ensembl; ENSRNOT00000044551; ENSRNOP00000063128; ENSRNOG00000070974.
DR GeneID; 296596; -.
DR KEGG; rno:296596; -.
DR UCSC; RGD:1307586; rat.
DR CTD; 6130; -.
DR RGD; 1307586; Rpl7a.
DR eggNOG; KOG3166; Eukaryota.
DR GeneTree; ENSGT00940000153294; -.
DR InParanoid; P62425; -.
DR OrthoDB; 1200503at2759; -.
DR PhylomeDB; P62425; -.
DR Reactome; R-RNO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-RNO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-RNO-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR Reactome; R-RNO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-RNO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-RNO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-RNO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P62425; -.
DR Proteomes; UP000002494; Chromosome 3.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IDA:RGD.
DR GO; GO:0022626; C:cytosolic ribosome; ISO:RGD.
DR GO; GO:0016020; C:membrane; ISO:RGD.
DR GO; GO:0005730; C:nucleolus; ISO:RGD.
DR GO; GO:0042788; C:polysomal ribosome; ISO:RGD.
DR GO; GO:0005840; C:ribosome; IDA:RGD.
DR GO; GO:0045202; C:synapse; ISO:RGD.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:RGD.
DR GO; GO:1904401; P:cellular response to Thyroid stimulating hormone; IEP:RGD.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR Gene3D; 3.30.1330.30; -; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR001921; Ribosomal_L7A/L8.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00882; RIBOSOMALL7A.
DR SUPFAM; SSF55315; SSF55315; 1.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Direct protein sequencing; Isopeptide bond;
KW Reference proteome; Ribonucleoprotein; Ribosomal protein; Ubl conjugation.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000269|PubMed:398910"
FT CHAIN 2..266
FT /note="60S ribosomal protein L7a"
FT /id="PRO_0000136750"
FT MOD_RES 34
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT MOD_RES 97
FT /note="N6-acetyllysine; alternate"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT MOD_RES 217
FT /note="N6-acetyllysine"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 11
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 20
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 21
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 48
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 97
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2); alternate"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 125
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CROSSLNK 245
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0000250|UniProtKB:P62424"
FT CONFLICT 33
FT /note="E -> Q (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
FT CONFLICT 35
FT /note="R -> S (in Ref. 2; AA sequence)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 266 AA; 29996 MW; 54EF43F221D9F704 CRC64;
MPKGKKAKGK KVAPAPAVVK KQEAKKVVNP LFEKRPKNFG IGQDIQPKRD LTRFVKWPRY
IRLQRQRAIL YKRLKVPPAI NQFTQALDRQ TATQLLKLAH KYRPETKQEK KQRLLARAEK
KAAGKGDVPT KRPPVLRAGV NTVTTLVENK KAQLVVIAHD VDPIELVVFL PALCRKMGVP
YCIIKGKARL GRLVHRKTCT TVAFTQVNSE DKGALAKLVE AIRTNYNDRY DEIRRHWGGN
VLGPKSVARI AKLEKAKAKE LATKLG
