RL7A_SACS2
ID RL7A_SACS2 Reviewed; 127 AA.
AC P55858;
DT 01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT 27-APR-2001, sequence version 2.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=50S ribosomal protein L7Ae {ECO:0000255|HAMAP-Rule:MF_00326};
DE AltName: Full=Ribosomal protein L8e {ECO:0000255|HAMAP-Rule:MF_00326};
GN Name=rpl7ae {ECO:0000255|HAMAP-Rule:MF_00326}; OrderedLocusNames=SSO0091;
GN ORFNames=C04_031;
OS Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
OS (Sulfolobus solfataricus).
OC Archaea; Crenarchaeota; Thermoprotei; Sulfolobales; Sulfolobaceae;
OC Saccharolobus.
OX NCBI_TaxID=273057;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=8899719; DOI=10.1111/j.1365-2958.1996.tb02666.x;
RA Sensen C.W., Klenk H.-P., Singh R.K., Allard G., Chan C.C.-Y., Liu Q.Y.,
RA Penny S.L., Young F., Schenk M.E., Gaasterland T., Doolittle W.F.,
RA Ragan M.A., Charlebois R.L.;
RT "Organizational characteristics and information content of an archaeal
RT genome: 156 kb of sequence from Sulfolobus solfataricus P2.";
RL Mol. Microbiol. 22:175-191(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 35092 / DSM 1617 / JCM 11322 / P2;
RX PubMed=11427726; DOI=10.1073/pnas.141222098;
RA She Q., Singh R.K., Confalonieri F., Zivanovic Y., Allard G., Awayez M.J.,
RA Chan-Weiher C.C.-Y., Clausen I.G., Curtis B.A., De Moors A., Erauso G.,
RA Fletcher C., Gordon P.M.K., Heikamp-de Jong I., Jeffries A.C., Kozera C.J.,
RA Medina N., Peng X., Thi-Ngoc H.P., Redder P., Schenk M.E., Theriault C.,
RA Tolstrup N., Charlebois R.L., Doolittle W.F., Duguet M., Gaasterland T.,
RA Garrett R.A., Ragan M.A., Sensen C.W., Van der Oost J.;
RT "The complete genome of the crenarchaeon Sulfolobus solfataricus P2.";
RL Proc. Natl. Acad. Sci. U.S.A. 98:7835-7840(2001).
RN [3]
RP SUBUNIT, SUBCELLULAR LOCATION, AND INDUCTION.
RX PubMed=19036786; DOI=10.1093/nar/gkn959;
RA Benelli D., Marzi S., Mancone C., Alonzi T., la Teana A., Londei P.;
RT "Function and ribosomal localization of aIF6, a translational regulator
RT shared by archaea and eukarya.";
RL Nucleic Acids Res. 37:256-267(2009).
RN [4]
RP X-RAY CRYSTALLOGRAPHY (4.01 ANGSTROMS) IN COMPLEX WITH RNA; S-NOP5 AND
RP FLPA, AND SUBUNIT.
RX PubMed=19666563; DOI=10.1073/pnas.0905128106;
RA Ye K., Jia R., Lin J., Ju M., Peng J., Xu A., Zhang L.;
RT "Structural organization of box C/D RNA-guided RNA methyltransferase.";
RL Proc. Natl. Acad. Sci. U.S.A. 106:13808-13813(2009).
CC -!- FUNCTION: Multifunctional RNA-binding protein that recognizes the K-
CC turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA,
CC box C/D and box C'/D' sRNAs.
CC -!- SUBUNIT: Part of the 50S ribosomal subunit. Component of box C/D small
CC ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5,
CC plus a guide RNA. These sRNP particles form homodimers, giving rise to
CC an asymmetric holoenzyme. Probably part of the RNase P complex.
CC {ECO:0000269|PubMed:19036786, ECO:0000269|PubMed:19666563}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00326,
CC ECO:0000269|PubMed:19036786}. Note=Found free in the cytoplasm and
CC associated with the 50S ribosomal subunit.
CC -!- INDUCTION: Constitutuively expressed (at protein level).
CC {ECO:0000269|PubMed:19036786}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL8 family.
CC {ECO:0000255|HAMAP-Rule:MF_00326}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAK40449.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA69560.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; Y08257; CAA69560.1; ALT_INIT; Genomic_DNA.
DR EMBL; AE006641; AAK40449.1; ALT_INIT; Genomic_DNA.
DR PIR; S75397; S75397.
DR RefSeq; WP_009988903.1; NC_002754.1.
DR PDB; 3ID5; X-ray; 4.01 A; C/G=1-127.
DR PDB; 5GIN; X-ray; 3.31 A; C/D/L=3-127.
DR PDB; 5GIO; X-ray; 3.60 A; C/D/L=3-127.
DR PDB; 5GIP; X-ray; 3.13 A; C/D/M/N=3-127.
DR PDB; 5JPQ; EM; 7.30 A; U/V=1-127.
DR PDBsum; 3ID5; -.
DR PDBsum; 5GIN; -.
DR PDBsum; 5GIO; -.
DR PDBsum; 5GIP; -.
DR PDBsum; 5JPQ; -.
DR AlphaFoldDB; P55858; -.
DR SMR; P55858; -.
DR DIP; DIP-48940N; -.
DR IntAct; P55858; 1.
DR STRING; 273057.SSO0091; -.
DR EnsemblBacteria; AAK40449; AAK40449; SSO0091.
DR GeneID; 44129051; -.
DR KEGG; sso:SSO0091; -.
DR PATRIC; fig|273057.12.peg.89; -.
DR eggNOG; arCOG01751; Archaea.
DR HOGENOM; CLU_084513_4_0_2; -.
DR InParanoid; P55858; -.
DR OMA; KPFYVRF; -.
DR PhylomeDB; P55858; -.
DR EvolutionaryTrace; P55858; -.
DR Proteomes; UP000001974; Chromosome.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0004526; F:ribonuclease P activity; IEA:UniProtKB-UniRule.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0000470; P:maturation of LSU-rRNA; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:UniProtKB-UniRule.
DR GO; GO:0001682; P:tRNA 5'-leader removal; IEA:UniProtKB-UniRule.
DR Gene3D; 3.30.1330.30; -; 1.
DR HAMAP; MF_00326; Ribosomal_L7Ae_Arch; 1.
DR InterPro; IPR029064; L30e-like.
DR InterPro; IPR004038; Ribosomal_L7Ae/L30e/S12e/Gad45.
DR InterPro; IPR018492; Ribosomal_L7Ae/L8/Nhp2.
DR InterPro; IPR022481; Ribosomal_L7Ae_arc.
DR InterPro; IPR004037; Ribosomal_L7Ae_CS.
DR InterPro; IPR000948; Ribosomal_L7Ae_prok.
DR Pfam; PF01248; Ribosomal_L7Ae; 1.
DR PRINTS; PR00881; L7ARS6FAMILY.
DR PRINTS; PR00884; RIBOSOMALHS6.
DR SUPFAM; SSF55315; SSF55315; 1.
DR TIGRFAMs; TIGR03677; eL8_ribo; 1.
DR PROSITE; PS01082; RIBOSOMAL_L7AE; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein; RNA-binding; rRNA-binding; tRNA processing.
FT CHAIN 1..127
FT /note="50S ribosomal protein L7Ae"
FT /id="PRO_0000136806"
FT HELIX 13..29
FT /evidence="ECO:0007829|PDB:5GIP"
FT STRAND 30..35
FT /evidence="ECO:0007829|PDB:5GIP"
FT HELIX 36..44
FT /evidence="ECO:0007829|PDB:5GIP"
FT STRAND 49..56
FT /evidence="ECO:0007829|PDB:5GIP"
FT HELIX 60..63
FT /evidence="ECO:0007829|PDB:5GIP"
FT HELIX 66..72
FT /evidence="ECO:0007829|PDB:5GIP"
FT STRAND 77..81
FT /evidence="ECO:0007829|PDB:5GIP"
FT HELIX 83..90
FT /evidence="ECO:0007829|PDB:5GIP"
FT STRAND 97..103
FT /evidence="ECO:0007829|PDB:5GIP"
FT HELIX 108..121
FT /evidence="ECO:0007829|PDB:5GIP"
SQ SEQUENCE 127 AA; 13736 MW; 3EE30FC81C1A003D CRC64;
MSKASYVKFE VPQDLADKVL EAVRKAKESG KIKKGTNETT KAVERGQAKL VIIAEDVQPE
EIVAHLPLLC DEKKIPYVYV SSKKALGEAC GLQVATASAA ILEPGEAKDL VDEIIKRVNE
IKGKTSS
