ID   AAXC_CHLCV              Reviewed;         486 AA.
AC   Q822F2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 110.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD; OrderedLocusNames=CCA_00731;
OS   Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)
OS   (Chlamydophila caviae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=227941;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-813 / DSM 19441 / 03DC25 / GPIC;
RX   PubMed=12682364; DOI=10.1093/nar/gkg321;
RA   Read T.D., Myers G.S.A., Brunham R.C., Nelson W.C., Paulsen I.T.,
RA   Heidelberg J.F., Holtzapple E.K., Khouri H.M., Federova N.B., Carty H.A.,
RA   Umayam L.A., Haft D.H., Peterson J.D., Beanan M.J., White O.,
RA   Salzberg S.L., Hsia R.-C., McClarty G., Rank R.G., Bavoil P.M.,
RA   Fraser C.M.;
RT   "Genome sequence of Chlamydophila caviae (Chlamydia psittaci GPIC):
RT   examining the role of niche-specific genes in the evolution of the
RT   Chlamydiaceae.";
RL   Nucleic Acids Res. 31:2134-2147(2003).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; AE015925; AAP05472.1; -; Genomic_DNA.
DR   RefSeq; WP_011006686.1; NC_003361.3.
DR   AlphaFoldDB; Q822F2; -.
DR   SMR; Q822F2; -.
DR   STRING; 227941.CCA_00731; -.
DR   EnsemblBacteria; AAP05472; AAP05472; CCA_00731.
DR   KEGG; cca:CCA_00731; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_007946_1_2_0; -.
DR   OMA; FNSDNRV; -.
DR   OrthoDB; 527053at2; -.
DR   Proteomes; UP000002193; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..486
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363174"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  52914 MW;  EAFEAC796A789A1F CRC64;
     MFLNRGKSKK NLGAIALAGM VISSMIGGGI FSLPQNMAAS AGAGAIILAW LLTGIGMFFI
     ANTFKILSLV RPDLTTGIYM YSREGFGPYV GFTIGWGYWL CQIFGNVGYA VMTMDALNYF
     FPPYFKGGNT IPAIIGGSIL IWVFNFIVLK GIRQASFINI IGTVCKLVPL IVFIIITAFA
     FKLAIFKTDF WGDAVTKTQP ALGSVTSQLK STMLVTLWAF IGIEGAVVMS ARAKSPSAVG
     KATLLGFVGC LTVYILLSIL PFGSLFQYQL AGIPNPSTAG VLGMLVGRWG EILMNVGLLI
     AILSSWLSWT IIVAEIPYTA ATNGTFPEIF AIENAQHSPK LSLYITSALM QITMLFVYFS
     TNAWNTMLSI TGVMVLPAYL ASAAFLFQFS KNKKYPNKGP VKSYIAKYTG FFAVIYSLWL
     IYAGGLNYLL MSVILLALGI PFYIDAGKKS KREKTFFAKK EVTKIIIIAL LALLAIFLFS
     TEKIRL