RL7L_HUMAN
ID RL7L_HUMAN Reviewed; 255 AA.
AC Q6DKI1; A8K7D4; B7Z652; Q5TFZ5; Q6PEK3;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 13-FEB-2019, sequence version 2.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=60S ribosomal protein L7-like 1;
DE AltName: Full=Large ribosomal subunit protein uL30-like 1;
GN Name=RPL7L1;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=14574404; DOI=10.1038/nature02055;
RA Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L.,
RA Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R.,
RA Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D.,
RA Andrews T.D., Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H.,
RA Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J.,
RA Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V.,
RA Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J.,
RA Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E.,
RA Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J.,
RA French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J.,
RA Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C.,
RA Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A.,
RA Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R.,
RA Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M.,
RA Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K.,
RA Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R.,
RA Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M.,
RA Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A.,
RA Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L.,
RA Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I.,
RA Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y.,
RA Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E.,
RA Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A.,
RA Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W.,
RA Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M.,
RA West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J.,
RA Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M.,
RA Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I.,
RA Rogers J., Beck S.;
RT "The DNA sequence and analysis of human chromosome 6.";
RL Nature 425:805-811(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 3-255 (ISOFORM 2), AND NUCLEOTIDE
RP SEQUENCE [LARGE SCALE MRNA] OF 7-255 (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-255 (ISOFORM 1).
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21269460; DOI=10.1186/1752-0509-5-17;
RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T.,
RA Bennett K.L., Superti-Furga G., Colinge J.;
RT "Initial characterization of the human central proteome.";
RL BMC Syst. Biol. 5:17-17(2011).
CC -!- INTERACTION:
CC Q6DKI1; O95273: CCNDBP1; NbExp=3; IntAct=EBI-1052408, EBI-748961;
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6DKI1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6DKI1-2; Sequence=VSP_056504;
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL30 family.
CC {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-10 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58020.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAH73890.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF84638.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAH13138.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL035587; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AK299816; BAH13138.1; ALT_INIT; mRNA.
DR EMBL; AK291949; BAF84638.1; ALT_INIT; mRNA.
DR EMBL; BC058020; AAH58020.1; ALT_INIT; mRNA.
DR EMBL; BC073890; AAH73890.1; ALT_INIT; mRNA.
DR CCDS; CCDS4873.2; -. [Q6DKI1-1]
DR RefSeq; NP_940888.3; NM_198486.3. [Q6DKI1-1]
DR RefSeq; XP_016866269.1; XM_017010780.1.
DR AlphaFoldDB; Q6DKI1; -.
DR SMR; Q6DKI1; -.
DR BioGRID; 130234; 200.
DR IntAct; Q6DKI1; 50.
DR MINT; Q6DKI1; -.
DR STRING; 9606.ENSP00000418221; -.
DR iPTMnet; Q6DKI1; -.
DR PhosphoSitePlus; Q6DKI1; -.
DR BioMuta; RPL7L1; -.
DR DMDM; 52783289; -.
DR EPD; Q6DKI1; -.
DR jPOST; Q6DKI1; -.
DR MassIVE; Q6DKI1; -.
DR MaxQB; Q6DKI1; -.
DR PaxDb; Q6DKI1; -.
DR PeptideAtlas; Q6DKI1; -.
DR PRIDE; Q6DKI1; -.
DR ProteomicsDB; 66230; -. [Q6DKI1-1]
DR ProteomicsDB; 6745; -.
DR Antibodypedia; 45922; 101 antibodies from 23 providers.
DR DNASU; 285855; -.
DR Ensembl; ENST00000304734.9; ENSP00000346063.4; ENSG00000146223.16. [Q6DKI1-1]
DR Ensembl; ENST00000493763.7; ENSP00000418221.3; ENSG00000146223.16. [Q6DKI1-1]
DR GeneID; 285855; -.
DR KEGG; hsa:285855; -.
DR MANE-Select; ENST00000493763.7; ENSP00000418221.3; NM_001366481.3; NP_001353410.1.
DR UCSC; uc003ost.4; human. [Q6DKI1-1]
DR CTD; 285855; -.
DR GeneCards; RPL7L1; -.
DR HGNC; HGNC:21370; RPL7L1.
DR HPA; ENSG00000146223; Low tissue specificity.
DR MIM; 617417; gene.
DR neXtProt; NX_Q6DKI1; -.
DR OpenTargets; ENSG00000146223; -.
DR PharmGKB; PA134977157; -.
DR VEuPathDB; HostDB:ENSG00000146223; -.
DR eggNOG; KOG3184; Eukaryota.
DR GeneTree; ENSGT00950000182878; -.
DR HOGENOM; CLU_055156_5_0_1; -.
DR InParanoid; Q6DKI1; -.
DR OMA; IEPFVVY; -.
DR PhylomeDB; Q6DKI1; -.
DR TreeFam; TF300740; -.
DR PathwayCommons; Q6DKI1; -.
DR SignaLink; Q6DKI1; -.
DR BioGRID-ORCS; 285855; 703 hits in 1012 CRISPR screens.
DR ChiTaRS; RPL7L1; human.
DR GenomeRNAi; 285855; -.
DR Pharos; Q6DKI1; Tdark.
DR PRO; PR:Q6DKI1; -.
DR Proteomes; UP000005640; Chromosome 6.
DR RNAct; Q6DKI1; protein.
DR Bgee; ENSG00000146223; Expressed in upper arm skin and 192 other tissues.
DR ExpressionAtlas; Q6DKI1; baseline and differential.
DR Genevisible; Q6DKI1; HS.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0005730; C:nucleolus; IEA:Ensembl.
DR GO; GO:0003723; F:RNA binding; HDA:UniProtKB.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0001825; P:blastocyst formation; IEA:Ensembl.
DR GO; GO:0000463; P:maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR CDD; cd01657; Ribosomal_L7_archeal_euk; 1.
DR Gene3D; 3.30.1390.20; -; 1.
DR InterPro; IPR036919; L30_ferredoxin-like_sf.
DR InterPro; IPR018038; Ribosomal_L30_CS.
DR InterPro; IPR016082; Ribosomal_L30_ferredoxin-like.
DR InterPro; IPR012988; Ribosomal_L30_N.
DR InterPro; IPR039699; Ribosomal_L7/L30.
DR InterPro; IPR005998; Ribosomal_L7_euk.
DR InterPro; IPR035808; Ribosomal_L7_euk_arc.
DR PANTHER; PTHR11524; PTHR11524; 1.
DR Pfam; PF00327; Ribosomal_L30; 1.
DR Pfam; PF08079; Ribosomal_L30_N; 1.
DR SUPFAM; SSF55129; SSF55129; 1.
DR TIGRFAMs; TIGR01310; uL30_euk; 1.
DR PROSITE; PS00634; RIBOSOMAL_L30; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Phosphoprotein; Reference proteome;
KW Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..255
FT /note="60S ribosomal protein L7-like 1"
FT /id="PRO_0000104659"
FT MOD_RES 63
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q9D8M4"
FT VAR_SEQ 151..255
FT /note="FPNLKSVRELILKRGQAKVKNKTIPLTDNTVIEEHLGKFGVICLEDLIHEIA
FT FPGKHFQEISWFLCPFHLSVARHATKNRVGFLKEMGTPGYRGERINQLIRQLN -> EV
FT WRHLLGRPHS (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_056504"
FT CONFLICT 6
FT /note="T -> G (in Ref. 3; AAH58020)"
FT /evidence="ECO:0000305"
FT CONFLICT 200
FT /note="E -> G (in Ref. 3; AAH58020)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 255 AA; 29669 MW; 78B5AA75AA723A2B CRC64;
MISSCTTRKM AEQEQRKIPL VPENLLKKRK AYQALKATQA KQALLAKKEQ KKGKGLRFKR
LESFLHDSWR QKRDKVRLRR LEVKPHALEL PDKHSLAFVV RIERIDGVSL LVQRTIARLR
LKKIFSGVFV KVTPQNLKML RIVEPYVTWG FPNLKSVREL ILKRGQAKVK NKTIPLTDNT
VIEEHLGKFG VICLEDLIHE IAFPGKHFQE ISWFLCPFHL SVARHATKNR VGFLKEMGTP
GYRGERINQL IRQLN
