ID   AAXC_CHLFF              Reviewed;         486 AA.
AC   Q255I1;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   18-APR-2006, sequence version 1.
DT   25-MAY-2022, entry version 90.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD; OrderedLocusNames=CF0285;
OS   Chlamydia felis (strain Fe/C-56) (Chlamydophila felis).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=264202;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Fe/C-56;
RX   PubMed=16766509; DOI=10.1093/dnares/dsi027;
RA   Azuma Y., Hirakawa H., Yamashita A., Cai Y., Rahman M.A., Suzuki H.,
RA   Mitaku S., Toh H., Goto S., Murakami T., Sugi K., Hayashi H., Fukushi H.,
RA   Hattori M., Kuhara S., Shirai M.;
RT   "Genome sequence of the cat pathogen, Chlamydophila felis.";
RL   DNA Res. 13:15-23(2006).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; AP006861; BAE81057.1; -; Genomic_DNA.
DR   RefSeq; WP_011457838.1; NC_007899.1.
DR   AlphaFoldDB; Q255I1; -.
DR   SMR; Q255I1; -.
DR   STRING; 264202.CF0285; -.
DR   KEGG; cfe:CF0285; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_007946_1_2_0; -.
DR   OMA; FNSDNRV; -.
DR   OrthoDB; 527053at2; -.
DR   Proteomes; UP000001260; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..486
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363175"
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        129..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        161..181
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..231
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        242..262
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        296..316
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        341..361
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        418..438
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..481
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   486 AA;  52702 MW;  EC06E8FEBC88F888 CRC64;
     MISNGSKTRK NLGAIALAGM VISSMIGGGI FSLPQNMAAS AGAGAIILAW ILTGIGMFFI
     ANTFKILSLV RPDLTTGIYM YSREGFGPYV GFTIGWGYWL CQIFGNVGYA VMTMDALNYF
     FPPYFKGGNT IPAIIGGSIL IWVFNFIVLK GIRQASFINV IGTICKLIPL LIFIIITAFF
     FKLAIFKTDF WGHTATKTQP LLGSVTSQLK STMLVTLWAF IGIEGAVVMS ARAKSPNAVG
     KATILGFSGC LIVYVLLSLL PFGSLFQHQL AGIANPSTAG VLDILVGRWG EILMNIGLLI
     AILSSWLSWT VIVAEIPYSA AKNGTFPEIF TIENAAHSPK VSLYITSALM QVAMLLVYFS
     TNAWSTMLSI TGVMVLPAYL ASAAFLVKFS KDKKYPNKGP IKSFTAKYTG ILAVIYSIWL
     IYAGGIKYLF MAIVLLALGI PFYIEAGKKG KNAKTFFAKK EVTKITIIAF LALLAIFLFS
     TERIRL