ID   AAXC_CHLPN              Reviewed;         485 AA.
AC   Q9Z6M8; Q7BWL4; Q9JS75; Q9K1X7;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 132.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD;
GN   OrderedLocusNames=CPn_1031, CP_0821, CPj1031, CpB1071;
OS   Chlamydia pneumoniae (Chlamydophila pneumoniae).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=83558;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CWL029;
RX   PubMed=10192388; DOI=10.1038/7716;
RA   Kalman S., Mitchell W.P., Marathe R., Lammel C.J., Fan J., Hyman R.W.,
RA   Olinger L., Grimwood J., Davis R.W., Stephens R.S.;
RT   "Comparative genomes of Chlamydia pneumoniae and C. trachomatis.";
RL   Nat. Genet. 21:385-389(1999).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AR39;
RX   PubMed=10684935; DOI=10.1093/nar/28.6.1397;
RA   Read T.D., Brunham R.C., Shen C., Gill S.R., Heidelberg J.F., White O.,
RA   Hickey E.K., Peterson J.D., Utterback T.R., Berry K.J., Bass S.,
RA   Linher K.D., Weidman J.F., Khouri H.M., Craven B., Bowman C., Dodson R.J.,
RA   Gwinn M.L., Nelson W.C., DeBoy R.T., Kolonay J.F., McClarty G.,
RA   Salzberg S.L., Eisen J.A., Fraser C.M.;
RT   "Genome sequences of Chlamydia trachomatis MoPn and Chlamydia pneumoniae
RT   AR39.";
RL   Nucleic Acids Res. 28:1397-1406(2000).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=J138;
RX   PubMed=10871362; DOI=10.1093/nar/28.12.2311;
RA   Shirai M., Hirakawa H., Kimoto M., Tabuchi M., Kishi F., Ouchi K.,
RA   Shiba T., Ishii K., Hattori M., Kuhara S., Nakazawa T.;
RT   "Comparison of whole genome sequences of Chlamydia pneumoniae J138 from
RT   Japan and CWL029 from USA.";
RL   Nucleic Acids Res. 28:2311-2314(2000).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TW-183;
RA   Geng M.M., Schuhmacher A., Muehldorfer I., Bensch K.W., Schaefer K.P.,
RA   Schneider S., Pohl T., Essig A., Marre R., Melchers K.;
RT   "The genome sequence of Chlamydia pneumoniae TW183 and comparison with
RT   other Chlamydia strains based on whole genome sequence analysis.";
RL   Submitted (MAY-2002) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   FUNCTION IN ARGININE UPTAKE, AND SUBCELLULAR LOCATION.
RC   STRAIN=Kajaani 6;
RX   PubMed=18790867; DOI=10.1128/jb.00652-08;
RA   Smith C.B., Graham D.E.;
RT   "Outer and inner membrane proteins compose an arginine-agmatine exchange
RT   system in Chlamydophila pneumoniae.";
RL   J. Bacteriol. 190:7431-7440(2008).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response.
CC       {ECO:0000269|PubMed:18790867}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane
CC       {ECO:0000269|PubMed:18790867}; Multi-pass membrane protein
CC       {ECO:0000269|PubMed:18790867}.
CC   -!- MISCELLANEOUS: Inhibited by L-canavanine and D-arginine. Resistant to
CC       cadaverine, L-lysine and L-ornithine.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAA99238.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR   EMBL; AE001363; AAD19168.1; -; Genomic_DNA.
DR   EMBL; AE002161; AAF73708.1; -; Genomic_DNA.
DR   EMBL; BA000008; BAA99238.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; AE009440; AAP99000.1; -; Genomic_DNA.
DR   PIR; A72006; A72006.
DR   PIR; D86619; D86619.
DR   RefSeq; NP_225225.1; NC_000922.1.
DR   RefSeq; WP_010892188.1; NZ_LN846995.1.
DR   AlphaFoldDB; Q9Z6M8; -.
DR   SMR; Q9Z6M8; -.
DR   STRING; 115711.CP_0821; -.
DR   TCDB; 2.A.3.2.7; the amino acid-polyamine-organocation (apc) family.
DR   EnsemblBacteria; AAD19168; AAD19168; CPn_1031.
DR   EnsemblBacteria; AAF73708; AAF73708; CP_0821.
DR   GeneID; 45051089; -.
DR   KEGG; cpa:CP_0821; -.
DR   KEGG; cpj:arcD; -.
DR   KEGG; cpn:CPn_1031; -.
DR   KEGG; cpt:CpB1071; -.
DR   PATRIC; fig|115713.3.peg.1129; -.
DR   eggNOG; COG0531; Bacteria.
DR   HOGENOM; CLU_007946_1_2_0; -.
DR   Proteomes; UP000000583; Chromosome.
DR   Proteomes; UP000000801; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
PE   1: Evidence at protein level;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..485
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363172"
FT   TRANSMEM        12..34
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        38..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        89..111
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        126..148
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        155..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        211..230
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        291..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        363..385
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        400..422
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        427..446
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        461..483
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        479
FT                   /note="S -> L (in Ref. 1; AAD19168)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   485 AA;  52548 MW;  C1269804B338BD33 CRC64;
     MTSRTKSSKN LGTIALAGMV VSSIIGGGIF SLPQNMAATA GAGAVILSWI LTGFGMFFIA
     NTFRILSTIR PDLKEGIYMY SREGFGPYIG FTIGWGYWLC QIFGNVGYAV ITMDALNYFF
     PPYFQGGNTL PAILGGSILI WVFNFIVLKG IRQASIINVI GTIFKIIPLI IFIILTAFFF
     KLAVFKTDFW GHAVTKAQPS LGSVSSQLKG TMLVTLWAFI GIEGAVVMSG RAKNPLSVGQ
     ATVLGFLGCL TIYILFSLLP FGSLFQHQLA NIPNPSTAGV LDILVGKWGE VLMNVGLIIA
     VLSSWLSWTI IVAEIPFSAA KNGTFPEIFT IENKEKSPSV SLYITSSVMQ LAMLLVYFSS
     NAWNTMLSIT GVMVLPAYLA SAAFLFKLSK SKTYPKKGSI KAPLAMITGI LGVVYSLWLI
     YAGGLKYLFM ALVLLALGIP FYIDAGKKKK NAKTFFAKKE IVGMTFIGLL ALTAIFLFST
     GRIKI