ID   AAXC_CHLTA              Reviewed;         483 AA.
AC   Q3KLY0; Q3KLY1; Q3KLY2;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   10-FEB-2009, sequence version 2.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD; OrderedLocusNames=CTA_0406/CTA_0407/CTA_0408;
OS   Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=315277;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-571B / DSM 19440 / HAR-13;
RX   PubMed=16177312; DOI=10.1128/iai.73.10.6407-6418.2005;
RA   Carlson J.H., Porcella S.F., McClarty G., Caldwell H.D.;
RT   "Comparative genomic analysis of Chlamydia trachomatis oculotropic and
RT   genitotropic strains.";
RL   Infect. Immun. 73:6407-6418(2005).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAX50640.1; Type=Frameshift; Note=CTA_0406, CTA_0407 and CTA_0408 have been merged into one gene.; Evidence={ECO:0000305};
CC       Sequence=AAX50641.1; Type=Frameshift; Note=CTA_0406, CTA_0407 and CTA_0408 have been merged into one gene.; Evidence={ECO:0000305};
CC       Sequence=AAX50642.1; Type=Frameshift; Note=CTA_0406, CTA_0407 and CTA_0408 have been merged into one gene.; Evidence={ECO:0000305};
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DR   EMBL; CP000051; AAX50640.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CP000051; AAX50641.1; ALT_FRAME; Genomic_DNA.
DR   EMBL; CP000051; AAX50642.1; ALT_FRAME; Genomic_DNA.
DR   AlphaFoldDB; Q3KLY0; -.
DR   SMR; Q3KLY0; -.
DR   EnsemblBacteria; AAX50640; AAX50640; CTA_0406.
DR   EnsemblBacteria; AAX50641; AAX50641; CTA_0407.
DR   EnsemblBacteria; AAX50642; AAX50642; CTA_0408.
DR   KEGG; cta:CTA_0406; -.
DR   KEGG; cta:CTA_0407; -.
DR   KEGG; cta:CTA_0408; -.
DR   HOGENOM; CLU_154931_1_0_0; -.
DR   Proteomes; UP000002532; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Transmembrane; Transmembrane helix; Transport; Virulence.
FT   CHAIN           1..483
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363177"
FT   TRANSMEM        11..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        41..61
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..105
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        124..144
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        157..177
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        208..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        239..259
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        289..309
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        364..384
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..478
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  52658 MW;  DAC657500A1A8A69 CRC64;
     MLLKKRSPTS ILGTLALTGI VISSMIGGGI FSLPQNMVAS ASAGAVMLAW MLSGIGIFFI
     ANTFKTLSII RPDLKAGIYT YSREGFGPYV GFTIAWGYWL CQIFGNVDYA VITMDALNYF
     FPPYFAGGNT IPAILLGSLL IWIFNYIVLR GIRQASFVNI IGAVCTLIPL LLFILITARF
     FKFSIFKTDF WGTAPQHTLG SIGSQLKSTM LVTLWAFIGI EGAVVISGRA ANLSSVGKAT
     ILGFSGCLLI YVLLSLLPFG SLFQYQLAKI ADPSTAGVLN ILVGKWGEVL MNTGLLIAVL
     TSWLSWTILA SEIPYAAAKN GTFPECFAIE NSKHAPSFSL FMTSGLMQIT MLLVYFSSNA
     WNTMLEITGV MVLPAYLTSS LFLVKFSLSK KYPKQAAIKA RIAMITSLLG SLYSLWLIYA
     GGLQHLFMVA ILLALGIPFY VDSGIRHKQE KTFLNRKEIL KMTIVALAAL LAIFLFSANK
     IHL