ID   AAXC_CHLTR              Reviewed;         483 AA.
AC   O84379;
DT   10-FEB-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1998, sequence version 1.
DT   25-MAY-2022, entry version 110.
DE   RecName: Full=Arginine/agmatine antiporter;
GN   Name=aaxC; Synonyms=arcD; OrderedLocusNames=CT_374;
OS   Chlamydia trachomatis (strain D/UW-3/Cx).
OC   Bacteria; Chlamydiae; Chlamydiales; Chlamydiaceae;
OC   Chlamydia/Chlamydophila group; Chlamydia.
OX   NCBI_TaxID=272561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=D/UW-3/Cx;
RX   PubMed=9784136; DOI=10.1126/science.282.5389.754;
RA   Stephens R.S., Kalman S., Lammel C.J., Fan J., Marathe R., Aravind L.,
RA   Mitchell W.P., Olinger L., Tatusov R.L., Zhao Q., Koonin E.V., Davis R.W.;
RT   "Genome sequence of an obligate intracellular pathogen of humans: Chlamydia
RT   trachomatis.";
RL   Science 282:754-759(1998).
CC   -!- FUNCTION: Catalyzes the exchange of L-arginine for agmatine. The
CC       arginine uptake by the bacterium in the macrophage may be a virulence
CC       factor against the host innate immune response (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell inner membrane {ECO:0000250}; Multi-pass
CC       membrane protein {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the amino acid-polyamine-organocation (APC)
CC       superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2)
CC       family. {ECO:0000305}.
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DR   EMBL; AE001273; AAC67970.1; -; Genomic_DNA.
DR   PIR; G71523; G71523.
DR   RefSeq; NP_219883.1; NC_000117.1.
DR   RefSeq; WP_009873122.1; NC_000117.1.
DR   AlphaFoldDB; O84379; -.
DR   SMR; O84379; -.
DR   STRING; 813.O172_02045; -.
DR   EnsemblBacteria; AAC67970; AAC67970; CT_374.
DR   GeneID; 884744; -.
DR   KEGG; ctr:CT_374; -.
DR   PATRIC; fig|272561.5.peg.403; -.
DR   HOGENOM; CLU_007946_1_2_0; -.
DR   InParanoid; O84379; -.
DR   OMA; FNSDNRV; -.
DR   Proteomes; UP000000431; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015297; F:antiporter activity; IEA:UniProtKB-KW.
DR   GO; GO:0006865; P:amino acid transport; IEA:UniProtKB-KW.
DR   InterPro; IPR002293; AA/rel_permease1.
DR   InterPro; IPR004754; Amino_acid_antiprt.
DR   Pfam; PF13520; AA_permease_2; 1.
DR   TIGRFAMs; TIGR00905; 2A0302; 1.
PE   3: Inferred from homology;
KW   Amino-acid transport; Antiport; Cell inner membrane; Cell membrane;
KW   Membrane; Reference proteome; Transmembrane; Transmembrane helix;
KW   Transport; Virulence.
FT   CHAIN           1..483
FT                   /note="Arginine/agmatine antiporter"
FT                   /id="PRO_0000363178"
FT   TRANSMEM        9..31
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        46..64
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        85..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        127..149
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        156..178
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        209..228
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        241..263
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        293..315
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        335..357
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        415..435
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        458..477
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   483 AA;  52658 MW;  DAC657500A1A8A69 CRC64;
     MLLKKRSPTS ILGTLALTGI VISSMIGGGI FSLPQNMVAS ASAGAVMLAW MLSGIGIFFI
     ANTFKTLSII RPDLKAGIYT YSREGFGPYV GFTIAWGYWL CQIFGNVDYA VITMDALNYF
     FPPYFAGGNT IPAILLGSLL IWIFNYIVLR GIRQASFVNI IGAVCTLIPL LLFILITARF
     FKFSIFKTDF WGTAPQHTLG SIGSQLKSTM LVTLWAFIGI EGAVVISGRA ANLSSVGKAT
     ILGFSGCLLI YVLLSLLPFG SLFQYQLAKI ADPSTAGVLN ILVGKWGEVL MNTGLLIAVL
     TSWLSWTILA SEIPYAAAKN GTFPECFAIE NSKHAPSFSL FMTSGLMQIT MLLVYFSSNA
     WNTMLEITGV MVLPAYLTSS LFLVKFSLSK KYPKQAAIKA RIAMITSLLG SLYSLWLIYA
     GGLQHLFMVA ILLALGIPFY VDSGIRHKQE KTFLNRKEIL KMTIVALAAL LAIFLFSANK
     IHL