ID   AB10A_ARATH             Reviewed;         909 AA.
AC   Q9FLT4; F4K3L8;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   22-SEP-2009, sequence version 2.
DT   03-AUG-2022, entry version 137.
DE   RecName: Full=ABC transporter A family member 10;
DE            Short=ABC transporter ABCA.10;
DE            Short=AtABCA10;
DE   AltName: Full=ABC2 homolog 14;
GN   Name=ABCA10; Synonyms=ATH14; OrderedLocusNames=At5g61740; ORFNames=MAC9.5;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT   features of the regions of 1,456,315 bp covered by nineteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [3]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-555, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX   PubMed=15308754; DOI=10.1105/tpc.104.023150;
RA   Nuehse T.S., Stensballe A., Jensen O.N., Peck S.C.;
RT   "Phosphoproteomics of the Arabidopsis plasma membrane and a new
RT   phosphorylation site database.";
RL   Plant Cell 16:2394-2405(2004).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAB10074.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR   EMBL; AB010069; BAB10074.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; CP002688; AED97511.2; -; Genomic_DNA.
DR   RefSeq; NP_001318860.1; NM_001345494.1.
DR   AlphaFoldDB; Q9FLT4; -.
DR   SMR; Q9FLT4; -.
DR   BioGRID; 21540; 1.
DR   STRING; 3702.AT5G61740.1; -.
DR   iPTMnet; Q9FLT4; -.
DR   PRIDE; Q9FLT4; -.
DR   ProteomicsDB; 244595; -.
DR   EnsemblPlants; AT5G61740.1; AT5G61740.1; AT5G61740.
DR   GeneID; 836296; -.
DR   Gramene; AT5G61740.1; AT5G61740.1; AT5G61740.
DR   KEGG; ath:AT5G61740; -.
DR   Araport; AT5G61740; -.
DR   eggNOG; KOG0059; Eukaryota.
DR   InParanoid; Q9FLT4; -.
DR   OrthoDB; 130188at2759; -.
DR   PhylomeDB; Q9FLT4; -.
DR   BioCyc; ARA:AT5G61740-MON; -.
DR   PRO; PR:Q9FLT4; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FLT4; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   1: Evidence at protein level;
KW   ATP-binding; Membrane; Nucleotide-binding; Phosphoprotein;
KW   Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..909
FT                   /note="ABC transporter A family member 10"
FT                   /id="PRO_0000240332"
FT   TRANSMEM        35..55
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        320..340
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        374..394
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        406..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        433..453
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        465..485
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        507..527
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          587..824
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         625..632
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   MOD_RES         555
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0007744|PubMed:15308754"
SQ   SEQUENCE   909 AA;  101045 MW;  58EA0F3C0B58C30B CRC64;
     MADPSQASFW AQANALLRKN LTYQRRHIWT NIRLVLVPLL LCLFLLGIQL LLDVVVNKAA
     DLTKCGSQDD FSIGDCPIPN PPLLPPLLQI PEPESRAVSG GFFSYNDLPD KSCRKTGTCP
     VTILLTGNNH SLGQALSGNM FGGSFAVNSS DLLSSLAYNV LGSTLALGTN NYADPGIESD
     FPIYSIQSQC SPNSTWPLSF GKIHTAVTCL QGLSLWRNNS VEVNDELFKG NWKGNPERMT
     NEIAAAYDLL NTDRNNFDVT IWYNSTNIDD PSRAPLVRVP RLLNLVSNAY LKFLKGPGTR
     ILFEFVKEVP KHQTKFNLDI ASMLGPLFFT WVVLLLFPVI LTSLVYEKQE RLRIIMKMHG
     LGIGPYWMIS YAYFLTLSMF YVISLVIFGS AIGLRYFRLN DYSVQFIFYF IFVNLQISFA
     FLASSIFSKV KTATVVAYTL VFASGLLGMF LFGELLESPT FPEKGILALE LYPGFSLFRG
     LYEFAQYASR GNGMKWKDLK ESGMDKLFYL MSVEWFVILI VAYSIDLLSS SGRSPFVFFK
     KSSSLPSPSV QRQNSENVLI DMEKTDVTQE REKVEKLRKE GTTGHAIVCD NLKKVYPGSD
     GNPPKLAVRG LYLDVPSGEC FGMLGPNGAG KTSFINMMTG LLKPTSGTAL VQGLDICKDM
     NKVYTSMGVC PQHDLLWGTL TGREHLLFYG RLKNIKGSAL MQAVEESLKS VSLFDGGVAD
     KPAGKYSGGM KRRLSVAISL IGNPKVVYMD EPSTGLDPAS RKDLWTVIQR AKQNTAIILT
     THSMEEAEFL CDRLGIFVDG GLQCVGNPKE LKGRYGGSYV FTMTTSVEHE EKVERMVKHI
     SPNSKRVYHL AGTQKFEIPK QEVMIADVFF MVEKVKSKFT VFAWGLADTT LEDVFFKVAT
     TAQAFNSLS