RL8_ANOGA
ID RL8_ANOGA Reviewed; 261 AA.
AC Q9U9L2; Q7PPA8;
DT 31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT 30-MAY-2006, sequence version 2.
DT 25-MAY-2022, entry version 119.
DE RecName: Full=60S ribosomal protein L8;
GN Name=RpL8; ORFNames=AGAP005802;
OS Anopheles gambiae (African malaria mosquito).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae;
OC Anophelinae; Anopheles.
OX NCBI_TaxID=7165;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=M2; TISSUE=Salivary gland;
RA Fidock D.A., Nguyen T.V., James A.A.;
RT "Subtractive hybridization of Plasmodium falciparum.";
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PEST;
RX PubMed=12364791; DOI=10.1126/science.1076181;
RA Holt R.A., Subramanian G.M., Halpern A., Sutton G.G., Charlab R.,
RA Nusskern D.R., Wincker P., Clark A.G., Ribeiro J.M.C., Wides R.,
RA Salzberg S.L., Loftus B.J., Yandell M.D., Majoros W.H., Rusch D.B., Lai Z.,
RA Kraft C.L., Abril J.F., Anthouard V., Arensburger P., Atkinson P.W.,
RA Baden H., de Berardinis V., Baldwin D., Benes V., Biedler J., Blass C.,
RA Bolanos R., Boscus D., Barnstead M., Cai S., Center A., Chaturverdi K.,
RA Christophides G.K., Chrystal M.A.M., Clamp M., Cravchik A., Curwen V.,
RA Dana A., Delcher A., Dew I., Evans C.A., Flanigan M.,
RA Grundschober-Freimoser A., Friedli L., Gu Z., Guan P., Guigo R.,
RA Hillenmeyer M.E., Hladun S.L., Hogan J.R., Hong Y.S., Hoover J.,
RA Jaillon O., Ke Z., Kodira C.D., Kokoza E., Koutsos A., Letunic I.,
RA Levitsky A.A., Liang Y., Lin J.-J., Lobo N.F., Lopez J.R., Malek J.A.,
RA McIntosh T.C., Meister S., Miller J.R., Mobarry C., Mongin E., Murphy S.D.,
RA O'Brochta D.A., Pfannkoch C., Qi R., Regier M.A., Remington K., Shao H.,
RA Sharakhova M.V., Sitter C.D., Shetty J., Smith T.J., Strong R., Sun J.,
RA Thomasova D., Ton L.Q., Topalis P., Tu Z.J., Unger M.F., Walenz B.,
RA Wang A.H., Wang J., Wang M., Wang X., Woodford K.J., Wortman J.R., Wu M.,
RA Yao A., Zdobnov E.M., Zhang H., Zhao Q., Zhao S., Zhu S.C., Zhimulev I.,
RA Coluzzi M., della Torre A., Roth C.W., Louis C., Kalush F., Mural R.J.,
RA Myers E.W., Adams M.D., Smith H.O., Broder S., Gardner M.J., Fraser C.M.,
RA Birney E., Bork P., Brey P.T., Venter J.C., Weissenbach J., Kafatos F.C.,
RA Collins F.H., Hoffman S.L.;
RT "The genome sequence of the malaria mosquito Anopheles gambiae.";
RL Science 298:129-149(2002).
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC {ECO:0000305}.
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DR EMBL; AF164152; AAD47076.1; -; mRNA.
DR EMBL; AAAB01008960; EAA10780.3; -; Genomic_DNA.
DR RefSeq; XP_315817.2; XM_315817.4.
DR AlphaFoldDB; Q9U9L2; -.
DR SMR; Q9U9L2; -.
DR STRING; 7165.AGAP005802-PA; -.
DR PaxDb; Q9U9L2; -.
DR PRIDE; Q9U9L2; -.
DR GeneID; 1276470; -.
DR KEGG; aga:AgaP_AGAP005802; -.
DR CTD; 1276470; -.
DR VEuPathDB; VectorBase:AGAP005802; -.
DR eggNOG; KOG2309; Eukaryota.
DR HOGENOM; CLU_036235_0_3_1; -.
DR InParanoid; Q9U9L2; -.
DR OMA; SCIELRP; -.
DR OrthoDB; 1156335at2759; -.
DR PhylomeDB; Q9U9L2; -.
DR Proteomes; UP000007062; Chromosome 2L.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR Gene3D; 2.30.30.30; -; 1.
DR Gene3D; 2.40.50.140; -; 1.
DR Gene3D; 4.10.950.10; -; 1.
DR HAMAP; MF_01320_A; Ribosomal_L2_A; 1.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR InterPro; IPR014722; Rib_L2_dom2.
DR InterPro; IPR002171; Ribosomal_L2.
DR InterPro; IPR023672; Ribosomal_L2_arc.
DR InterPro; IPR022669; Ribosomal_L2_C.
DR InterPro; IPR022671; Ribosomal_L2_CS.
DR InterPro; IPR014726; Ribosomal_L2_dom3.
DR InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR PANTHER; PTHR13691; PTHR13691; 1.
DR Pfam; PF00181; Ribosomal_L2; 1.
DR Pfam; PF03947; Ribosomal_L2_C; 1.
DR PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR SMART; SM01383; Ribosomal_L2; 1.
DR SMART; SM01382; Ribosomal_L2_C; 1.
DR SUPFAM; SSF50104; SSF50104; 1.
DR SUPFAM; SSF50249; SSF50249; 1.
DR PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW RNA-binding; rRNA-binding.
FT CHAIN 1..261
FT /note="60S ribosomal protein L8"
FT /id="PRO_0000129753"
FT REGION 208..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 26
FT /note="E -> Q (in Ref. 1; AAD47076)"
FT /evidence="ECO:0000305"
FT CONFLICT 50
FT /note="H -> Q (in Ref. 1; AAD47076)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="L -> I (in Ref. 1; AAD47076)"
FT /evidence="ECO:0000305"
FT CONFLICT 166
FT /note="I -> V (in Ref. 1; AAD47076)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 261 AA; 28757 MW; 6CDFFE12B8DC1D16 CRC64;
MGRVIRAQRK GAGSVFRAHT KKRKGEPKLR HLDYAERHGY LKGVVKQIIH DPGRGAPLAV
VNFRDPYRFR LSKQLFIAAE GMYTGQFVYC GRRAQLQIGN VLPIGLMPEG TIVCNLEEKT
GDRGKLARTS GNYASVIAHN PDTKRTRVKL PSGAKKVLPS ANRAMIGIVA GGGRIDKPIL
KAGRAYHKYK VKRNCWPKVR GVAMNPVEHP HGGGNHQHIG KASTVKRGTP PGRKVGLIAA
RRTGRIRGGK GDEKFKEKEK K
