ID   RL8_CAEEL               Reviewed;         260 AA.
AC   Q9XVF7;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1999, sequence version 1.
DT   03-AUG-2022, entry version 143.
DE   RecName: Full=60S ribosomal protein L8;
GN   Name=rpl-2 {ECO:0000312|WormBase:B0250.1};
GN   Synonyms=rpl-8 {ECO:0000312|WormBase:B0250.1};
GN   ORFNames=B0250.1 {ECO:0000312|WormBase:B0250.1};
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000305}.
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DR   EMBL; Z81453; CAB03792.1; -; Genomic_DNA.
DR   PIR; T18676; T18676.
DR   RefSeq; NP_507940.1; NM_075539.5.
DR   AlphaFoldDB; Q9XVF7; -.
DR   SMR; Q9XVF7; -.
DR   BioGRID; 45300; 97.
DR   DIP; DIP-24785N; -.
DR   IntAct; Q9XVF7; 2.
DR   STRING; 6239.B0250.1; -.
DR   EPD; Q9XVF7; -.
DR   PaxDb; Q9XVF7; -.
DR   PeptideAtlas; Q9XVF7; -.
DR   PRIDE; Q9XVF7; -.
DR   EnsemblMetazoa; B0250.1.1; B0250.1.1; WBGene00004413.
DR   GeneID; 180343; -.
DR   KEGG; cel:CELE_B0250.1; -.
DR   UCSC; B0250.1.1; c. elegans.
DR   CTD; 180343; -.
DR   WormBase; B0250.1; CE18478; WBGene00004413; rpl-2.
DR   eggNOG; KOG2309; Eukaryota.
DR   GeneTree; ENSGT00940000153244; -.
DR   HOGENOM; CLU_036235_0_3_1; -.
DR   InParanoid; Q9XVF7; -.
DR   OMA; SCIELRP; -.
DR   OrthoDB; 1156335at2759; -.
DR   PhylomeDB; Q9XVF7; -.
DR   Reactome; R-CEL-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-CEL-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-CEL-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-CEL-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-CEL-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-CEL-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-CEL-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q9XVF7; -.
DR   Proteomes; UP000001940; Chromosome V.
DR   Bgee; WBGene00004413; Expressed in larva and 3 other tissues.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 4.10.950.10; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR002171; Ribosomal_L2.
DR   InterPro; IPR022669; Ribosomal_L2_C.
DR   InterPro; IPR022671; Ribosomal_L2_CS.
DR   InterPro; IPR014726; Ribosomal_L2_dom3.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR13691; PTHR13691; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   CHAIN           1..260
FT                   /note="60S ribosomal protein L8"
FT                   /id="PRO_0000129751"
FT   REGION          208..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   260 AA;  28204 MW;  EA8EA20430A79213 CRC64;
     MGRRIRIQRK GAGGIFKSHN KHRKGASKLR PLDYAERHGY IKGLVKDIIH DPGRGAPLAI
     IAFRDPYKYK TVKTTVVAAE GMHTGQFIHC GAKAQIQIGN IVPVGTLPEG TTICNVENKS
     GDRGVIARAS GNYATVIAHN PDTKKTRIRL PSGAKKVVQS VNRAMIGLVA GGGRTDKPLL
     KAGRSYHKYK AKRNSWPRVR GVAMNPVEHP HGGGNHQHIG HPSTVRRDAS AGKKVGLIAA
     RRTGRIRGGK PVKFTKEENV