ID   RL8_DANRE               Reviewed;         257 AA.
AC   Q6P0V6;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 115.
DE   RecName: Full=60S ribosomal protein L8;
GN   Name=rpl8; ORFNames=zgc:73105;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Eye;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JAN-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P62917}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P62917}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000305}.
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DR   EMBL; BC059473; AAH59473.1; -; mRNA.
DR   EMBL; BC065432; AAH65432.1; -; mRNA.
DR   RefSeq; NP_957007.1; NM_200713.1.
DR   RefSeq; XP_005167741.1; XM_005167684.1.
DR   AlphaFoldDB; Q6P0V6; -.
DR   SMR; Q6P0V6; -.
DR   STRING; 7955.ENSDARP00000115147; -.
DR   PaxDb; Q6P0V6; -.
DR   PRIDE; Q6P0V6; -.
DR   Ensembl; ENSDART00000006948; ENSDARP00000005651; ENSDARG00000014867.
DR   Ensembl; ENSDART00000140039; ENSDARP00000115147; ENSDARG00000014867.
DR   GeneID; 393686; -.
DR   KEGG; dre:393686; -.
DR   CTD; 6132; -.
DR   ZFIN; ZDB-GENE-040426-1670; rpl8.
DR   eggNOG; KOG2309; Eukaryota.
DR   GeneTree; ENSGT00940000153244; -.
DR   HOGENOM; CLU_036235_0_3_1; -.
DR   InParanoid; Q6P0V6; -.
DR   OMA; HPYKFKM; -.
DR   OrthoDB; 1156335at2759; -.
DR   PhylomeDB; Q6P0V6; -.
DR   TreeFam; TF300748; -.
DR   Reactome; R-DRE-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DRE-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DRE-6791226; Major pathway of rRNA processing in the nucleolus and cytosol.
DR   Reactome; R-DRE-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DRE-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DRE-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DRE-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:Q6P0V6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 9.
DR   Bgee; ENSDARG00000014867; Expressed in somite and 33 other tissues.
DR   ExpressionAtlas; Q6P0V6; baseline and differential.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 4.10.950.10; -; 1.
DR   HAMAP; MF_01320_A; Ribosomal_L2_A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR002171; Ribosomal_L2.
DR   InterPro; IPR023672; Ribosomal_L2_arc.
DR   InterPro; IPR022669; Ribosomal_L2_C.
DR   InterPro; IPR022671; Ribosomal_L2_CS.
DR   InterPro; IPR014726; Ribosomal_L2_dom3.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR13691; PTHR13691; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..257
FT                   /note="60S ribosomal protein L8"
FT                   /id="PRO_0000129749"
FT   REGION          207..230
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  28067 MW;  E77ED892E7411D9E CRC64;
     MGRVIRGQRK GAGSVFKAHV KHRKGAAKLR HIDFAERHGY IKGIVKDIIH DPGRGAPLAK
     VMFRDPYRFK KRTELFIAAE GIHTGQFIYC GKKAQLNIGN VLPVGTMPEG TIVCCLEEKP
     GDRGKLARAS GNYATVISHN PETKKSRVKL PSGSKKVISS ANRAVVGVVA GGGRIDKPIL
     KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA
     RRTGRLRGTK TVQDKEN