ID   RL8_DICDI               Reviewed;         255 AA.
AC   P13023; Q554Y1; Q86HT2;
DT   01-JAN-1990, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   25-MAY-2022, entry version 130.
DE   RecName: Full=60S ribosomal protein L8;
DE   AltName: Full=60S ribosomal protein L2;
GN   Name=rpl8; Synonyms=rpgA, rpl2, V1; ORFNames=DDB_G0274113;
OS   Dictyostelium discoideum (Slime mold).
OC   Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC   Dictyosteliaceae; Dictyostelium.
OX   NCBI_TaxID=44689;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=AX3;
RX   PubMed=2678007; DOI=10.1093/nar/17.19.7989;
RA   Singleton C.K.;
RT   "Nucleotide sequence of V1, a ribosomal protein gene from Dictyostelium
RT   discoideum.";
RL   Nucleic Acids Res. 17:7989-7989(1989).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=12097910; DOI=10.1038/nature00847;
RA   Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA   Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA   Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA   Noegel A.A.;
RT   "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL   Nature 418:79-85(2002).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AX4;
RX   PubMed=15875012; DOI=10.1038/nature03481;
RA   Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA   Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA   Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA   Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA   Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA   Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA   Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA   Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA   Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA   Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA   Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA   Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA   Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA   Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA   Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA   Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA   Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT   "The genome of the social amoeba Dictyostelium discoideum.";
RL   Nature 435:43-57(2005).
RN   [4]
RP   PROTEIN SEQUENCE OF 30-38; 44-61; 75-93; 108-120; 130-148; 165-182 AND
RP   229-242, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC   STRAIN=AX2;
RA   Bienvenut W.V., Ura S., Insall R.H.;
RL   Submitted (JUL-2009) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA33741.1; Type=Frameshift; Evidence={ECO:0000305};
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DR   EMBL; X15710; CAA33741.1; ALT_FRAME; mRNA.
DR   EMBL; AAFI02000012; EAL69949.1; -; Genomic_DNA.
DR   PIR; S06087; R5DO2.
DR   RefSeq; XP_644192.1; XM_639100.1.
DR   AlphaFoldDB; P13023; -.
DR   SMR; P13023; -.
DR   STRING; 44689.DDB0185202; -.
DR   PaxDb; P13023; -.
DR   EnsemblProtists; EAL69949; EAL69949; DDB_G0274113.
DR   GeneID; 8619621; -.
DR   KEGG; ddi:DDB_G0274113; -.
DR   dictyBase; DDB_G0274113; rpl8.
DR   eggNOG; KOG2309; Eukaryota.
DR   HOGENOM; CLU_036235_0_3_1; -.
DR   InParanoid; P13023; -.
DR   OMA; SCIELRP; -.
DR   PhylomeDB; P13023; -.
DR   Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P13023; -.
DR   Proteomes; UP000002195; Chromosome 2.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 4.10.950.10; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR002171; Ribosomal_L2.
DR   InterPro; IPR022669; Ribosomal_L2_C.
DR   InterPro; IPR022671; Ribosomal_L2_CS.
DR   InterPro; IPR014726; Ribosomal_L2_dom3.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR13691; PTHR13691; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   1: Evidence at protein level;
KW   Direct protein sequencing; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..255
FT                   /note="60S ribosomal protein L8"
FT                   /id="PRO_0000129731"
FT   REGION          211..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        100..101
FT                   /note="GN -> RH (in Ref. 1; CAA33741)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   255 AA;  27520 MW;  5B95E832D572D4E4 CRC64;
     MGRIIRAQRK GKAGSVFGAH THHRKGTPRF RALDYAERQG YVKGVVKEII HDPGRGAPLA
     RVVFKGLTQF KLDKQLFIAP EGMHTGQFVF AGKKATLTIG NILPIGKLPE GTIICNVEEK
     LGDCGAVARC SGNYATIVSH NPDEGVTRIK LPSGSKKNVS SLARAMIGIV AGGGRIDKPM
     LKAGRAFHKY RVKKNNWPKV RGVAMNPVEH PHGGGNHQHV GHATTTKRDD PAGKKVGLIA
     ARRTGRLRGT KNISE