ID   RL8_TETTS               Reviewed;         264 AA.
AC   P0DJ52;
DT   19-OCT-2011, integrated into UniProtKB/Swiss-Prot.
DT   19-OCT-2011, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=60S ribosomal protein L8;
GN   Name=RPL8; Synonyms=RPL2; ORFNames=TTHERM_00716240;
OS   Tetrahymena thermophila (strain SB210).
OC   Eukaryota; Sar; Alveolata; Ciliophora; Intramacronucleata;
OC   Oligohymenophorea; Hymenostomatida; Tetrahymenina; Tetrahymenidae;
OC   Tetrahymena.
OX   NCBI_TaxID=312017;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SB210;
RX   PubMed=16933976; DOI=10.1371/journal.pbio.0040286;
RA   Eisen J.A., Coyne R.S., Wu M., Wu D., Thiagarajan M., Wortman J.R.,
RA   Badger J.H., Ren Q., Amedeo P., Jones K.M., Tallon L.J., Delcher A.L.,
RA   Salzberg S.L., Silva J.C., Haas B.J., Majoros W.H., Farzad M.,
RA   Carlton J.M., Smith R.K. Jr., Garg J., Pearlman R.E., Karrer K.M., Sun L.,
RA   Manning G., Elde N.C., Turkewitz A.P., Asai D.J., Wilkes D.E., Wang Y.,
RA   Cai H., Collins K., Stewart B.A., Lee S.R., Wilamowska K., Weinberg Z.,
RA   Ruzzo W.L., Wloga D., Gaertig J., Frankel J., Tsao C.-C., Gorovsky M.A.,
RA   Keeling P.J., Waller R.F., Patron N.J., Cherry J.M., Stover N.A.,
RA   Krieger C.J., del Toro C., Ryder H.F., Williamson S.C., Barbeau R.A.,
RA   Hamilton E.P., Orias E.;
RT   "Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a
RT   model eukaryote.";
RL   PLoS Biol. 4:1620-1642(2006).
RN   [2]
RP   X-RAY CRYSTALLOGRAPHY (3.52 ANGSTROMS) OF 60S RIBOSOME.
RX   PubMed=22052974; DOI=10.1126/science.1211204;
RA   Klinge S., Voigts-Hoffmann F., Leibundgut M., Arpagaus S., Ban N.;
RT   "Crystal structure of the eukaryotic 60S ribosomal subunit in complex with
RT   initiation factor 6.";
RL   Science 334:941-948(2011).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000305}.
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DR   EMBL; GG662447; EAR84318.2; -; Genomic_DNA.
DR   RefSeq; XP_001031981.2; XM_001031981.2.
DR   PDB; 4V8P; X-ray; 3.52 A; BA/CA/EA/GA=1-264.
DR   PDBsum; 4V8P; -.
DR   AlphaFoldDB; P0DJ52; -.
DR   SMR; P0DJ52; -.
DR   IntAct; P0DJ52; 1.
DR   STRING; 5911.EAR84318; -.
DR   EnsemblProtists; EAR84318; EAR84318; TTHERM_00716240.
DR   GeneID; 7845569; -.
DR   KEGG; tet:TTHERM_00716240; -.
DR   eggNOG; KOG2309; Eukaryota.
DR   HOGENOM; CLU_036235_0_3_1; -.
DR   InParanoid; P0DJ52; -.
DR   OMA; SCIELRP; -.
DR   OrthoDB; 1156335at2759; -.
DR   Proteomes; UP000009168; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005840; C:ribosome; IEA:UniProtKB-KW.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR   GO; GO:0006412; P:translation; IEA:InterPro.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 4.10.950.10; -; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR002171; Ribosomal_L2.
DR   InterPro; IPR022669; Ribosomal_L2_C.
DR   InterPro; IPR022671; Ribosomal_L2_CS.
DR   InterPro; IPR014726; Ribosomal_L2_dom3.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR13691; PTHR13691; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cytoplasm; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein; RNA-binding; rRNA-binding.
FT   CHAIN           1..264
FT                   /note="60S ribosomal protein L8"
FT                   /id="PRO_0000413488"
SQ   SEQUENCE   264 AA;  28650 MW;  3A15F5E20A8BE067 CRC64;
     MGRVIRAQRK GRANGVYKSH KSGRIAPAQY RVYDFAERQG YIRGCIRDIV HEPGRGAPLA
     EVAFRDPYRY KTNKEHFIAA EGQYSGQYVY CGLKAQIAVG NVLPINRIPE GTVVCNVEEK
     VGDRGTFSRA SGCYATIIGH SEDGDKTRIR LPSGARKTIP GSCRATVGIV AGGGRTDKPI
     LKAGNQFHKY ARKRKSWPRV RGVAMNPVDH PHGGGNHQHI GHPATVSKWA SAGQKVGLRA
     ARRTGLVRGG QKEKMAMKAA AAGV