ID   RL8_XENTR               Reviewed;         257 AA.
AC   Q6PBF0; Q28HP9;
DT   31-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   23-JAN-2007, sequence version 3.
DT   03-AUG-2022, entry version 111.
DE   RecName: Full=60S ribosomal protein L8;
GN   Name=rpl8; ORFNames=TTpA008p15.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Tadpole;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (MAR-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of the large ribosomal subunit. The ribosome is a
CC       large ribonucleoprotein complex responsible for the synthesis of
CC       proteins in the cell. {ECO:0000250|UniProtKB:P62917}.
CC   -!- SUBUNIT: Component of the large ribosomal subunit.
CC       {ECO:0000250|UniProtKB:P62917}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL2 family.
CC       {ECO:0000305}.
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DR   EMBL; CR760793; CAJ83193.1; -; mRNA.
DR   EMBL; BC059744; AAH59744.1; -; mRNA.
DR   RefSeq; NP_988925.1; NM_203594.1.
DR   RefSeq; XP_012812090.1; XM_012956636.2.
DR   AlphaFoldDB; Q6PBF0; -.
DR   SMR; Q6PBF0; -.
DR   STRING; 8364.ENSXETP00000033787; -.
DR   PaxDb; Q6PBF0; -.
DR   DNASU; 394521; -.
DR   Ensembl; ENSXETT00000033787; ENSXETP00000033787; ENSXETG00000015483.
DR   GeneID; 394521; -.
DR   KEGG; xtr:394521; -.
DR   CTD; 6132; -.
DR   Xenbase; XB-GENE-482209; rpl8.
DR   eggNOG; KOG2309; Eukaryota.
DR   HOGENOM; CLU_036235_0_3_1; -.
DR   InParanoid; Q6PBF0; -.
DR   OMA; HPYKFKM; -.
DR   OrthoDB; 1156335at2759; -.
DR   PhylomeDB; Q6PBF0; -.
DR   TreeFam; TF300748; -.
DR   Reactome; R-XTR-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000015483; Expressed in structure with developmental contribution from neural crest and 32 other tissues.
DR   ExpressionAtlas; Q6PBF0; differential.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR   GO; GO:0003723; F:RNA binding; IBA:GO_Central.
DR   GO; GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   Gene3D; 2.30.30.30; -; 1.
DR   Gene3D; 2.40.50.140; -; 1.
DR   Gene3D; 4.10.950.10; -; 1.
DR   HAMAP; MF_01320_A; Ribosomal_L2_A; 1.
DR   InterPro; IPR012340; NA-bd_OB-fold.
DR   InterPro; IPR022666; Rbsml_prot_L2_RNA-bd_dom.
DR   InterPro; IPR014722; Rib_L2_dom2.
DR   InterPro; IPR002171; Ribosomal_L2.
DR   InterPro; IPR023672; Ribosomal_L2_arc.
DR   InterPro; IPR022669; Ribosomal_L2_C.
DR   InterPro; IPR022671; Ribosomal_L2_CS.
DR   InterPro; IPR014726; Ribosomal_L2_dom3.
DR   InterPro; IPR008991; Translation_prot_SH3-like_sf.
DR   PANTHER; PTHR13691; PTHR13691; 1.
DR   Pfam; PF00181; Ribosomal_L2; 1.
DR   Pfam; PF03947; Ribosomal_L2_C; 1.
DR   PIRSF; PIRSF002158; Ribosomal_L2; 1.
DR   SMART; SM01383; Ribosomal_L2; 1.
DR   SMART; SM01382; Ribosomal_L2_C; 1.
DR   SUPFAM; SSF50104; SSF50104; 1.
DR   SUPFAM; SSF50249; SSF50249; 1.
DR   PROSITE; PS00467; RIBOSOMAL_L2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Reference proteome; Ribonucleoprotein; Ribosomal protein;
KW   RNA-binding; rRNA-binding.
FT   INIT_MET        1
FT                   /note="Removed"
FT                   /evidence="ECO:0000250"
FT   CHAIN           2..257
FT                   /note="60S ribosomal protein L8"
FT                   /id="PRO_0000129748"
FT   REGION          207..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   257 AA;  27927 MW;  20184EC3ACB097A7 CRC64;
     MGRVIRGQRK GAGSVFKAHV KHRKGAAKLR AVDFAERHGY IKGIVKDIIH DPGRGAPLAK
     VAFRDPYRFK KRTELFVAAE GIHTGQFVYC GKKAQLNIGN VLPVGTMPEG TIVCCVEEKP
     GDRGKLARAS GNYATVISHN PETKKTRVKL PSGSKKVISS ANRAIVGVVA GGGRIDKPIL
     KAGRAYHKYK AKRNCWPRVR GVAMNPVEHP FGGGNHQHIG KPSTIRRDAP AGRKVGLIAA
     RRTGRLRGTK TVQEKEN