AB10B_ARATH
ID AB10B_ARATH Reviewed; 1227 AA.
AC Q9SGY1;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-MAR-2009, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=ABC transporter B family member 10;
DE Short=ABC transporter ABCB.10;
DE Short=AtABCB10;
DE AltName: Full=Multidrug resistance protein 10;
DE AltName: Full=P-glycoprotein 10;
GN Name=ABCB10; Synonyms=MDR10, PGP10; OrderedLocusNames=At1g10680;
GN ORFNames=F20B24.12;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP PROTEIN SEQUENCE OF 22-28; 29-40; 953-958 AND 1247-1254, AND INTERACTION
RP WITH NPA.
RX PubMed=16243904; DOI=10.1105/tpc.105.035816;
RA Terasaka K., Blakeslee J.J., Titapiwatanakun B., Peer W.A.,
RA Bandyopadhyay A., Makam S.N., Lee O.R., Richards E.L., Murphy A.S.,
RA Sato F., Yazaki K.;
RT "PGP4, an ATP binding cassette P-glycoprotein, catalyzes auxin transport in
RT Arabidopsis thaliana roots.";
RL Plant Cell 17:2922-2939(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
RN [6]
RP INDUCTION BY NAC045 AND NAC086, AND TISSUE SPECIFICITY.
RX PubMed=25081480; DOI=10.1126/science.1253736;
RA Furuta K.M., Yadav S.R., Lehesranta S., Belevich I., Miyashima S.,
RA Heo J.O., Vaten A., Lindgren O., De Rybel B., Van Isterdael G.,
RA Somervuo P., Lichtenberger R., Rocha R., Thitamadee S., Taehtiharju S.,
RA Auvinen P., Beeckman T., Jokitalo E., Helariutta Y.;
RT "Plant development. Arabidopsis NAC45/86 direct sieve element morphogenesis
RT culminating in enucleation.";
RL Science 345:933-937(2014).
CC -!- SUBUNIT: Interacts with 1-naphthylphthalamic acid (NPA).
CC {ECO:0000269|PubMed:16243904}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- TISSUE SPECIFICITY: Expressed in the sieve elements.
CC {ECO:0000269|PubMed:25081480}.
CC -!- INDUCTION: Regulated by the transcription factors NAC045 and NAC086.
CC {ECO:0000269|PubMed:25081480}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF17668.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009398; AAF17668.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE28628.1; -; Genomic_DNA.
DR PIR; B86240; B86240.
DR RefSeq; NP_172538.1; NM_100944.2.
DR AlphaFoldDB; Q9SGY1; -.
DR SMR; Q9SGY1; -.
DR STRING; 3702.AT1G10680.1; -.
DR PaxDb; Q9SGY1; -.
DR PRIDE; Q9SGY1; -.
DR ProteomicsDB; 245080; -.
DR EnsemblPlants; AT1G10680.1; AT1G10680.1; AT1G10680.
DR GeneID; 837611; -.
DR Gramene; AT1G10680.1; AT1G10680.1; AT1G10680.
DR KEGG; ath:AT1G10680; -.
DR Araport; AT1G10680; -.
DR TAIR; locus:2019958; AT1G10680.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; Q9SGY1; -.
DR OMA; YRVRHEV; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; Q9SGY1; -.
DR BioCyc; ARA:AT1G10680-MON; -.
DR PRO; PR:Q9SGY1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SGY1; baseline and differential.
DR Genevisible; Q9SGY1; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005739; C:mitochondrion; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 1: Evidence at protein level;
KW ATP-binding; Direct protein sequencing; Glycoprotein; Membrane;
KW Nucleotide-binding; Reference proteome; Repeat; Transmembrane;
KW Transmembrane helix; Transport.
FT CHAIN 1..1227
FT /note="ABC transporter B family member 10"
FT /id="PRO_0000227921"
FT TRANSMEM 38..62
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 90..110
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 169..188
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 194..214
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 269..289
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 704..724
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 784..804
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 806..826
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 889..909
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 927..947
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 41..330
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 361..597
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 662..949
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 982..1218
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 396..403
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1017..1024
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 758
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 834
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1227 AA; 134475 MW; 4B1AB2A1DF082348 CRC64;
MQPSNDPAIV DMAAAEKEKK RPSVSFLKLF SFADFYDCVL MALGSIGACI HGASVPVFFI
FFGKLINIIG LAYLFPQEAS HKVAKYSLDF VYLSVVILFS SWLEVACWMH TGERQAAKIR
KAYLRSMLSQ DISLFDTEIS TGEVISAITS EILVVQDAIS EKVGNFMHFI SRFIAGFAIG
FASVWQISLV TLSIVPFIAL AGGIYAFVSS GLIVRVRKSY VKANEIAEEV IGNVRTVQAF
TGEEKAVSSY QGALRNTYNY GRKAGLAKGL GLGSLHFVLF LSWALLIWFT SIVVHKGIAN
GGESFTTMLN VVIAGLSLGQ AAPDISTFMR ASAAAYPIFQ MIERNTEDKT GRKLGNVNGD
ILFKDVTFTY PSRPDVVIFD KLNFVIPAGK VVALVGGSGS GKSTMISLIE RFYEPTDGAV
MLDGNDIRYL DLKWLRGHIG LVNQEPVLFA TTIRENIMYG KDDATSEEIT NAAKLSEAIS
FINNLPEGFE TQVGERGIQL SGGQKQRISI SRAIVKNPSI LLLDEATSAL DAESEKIVQE
ALDRVMVGRT TVVVAHRLST VRNADIIAVV GGGKIIESGS HDELISNPDG AYSSLLRIQE
AASPNLNHTP SLPVSTKPLP ELPITETTSS IHQSVNQPDT TKQAKVTVGR LYSMIRPDWK
YGLCGTLGSF IAGSQMPLFA LGIAQALVSY YMDWETTQNE VKRISILFCC GSVITVIVHT
IEHTTFGIMG ERLTLRVRQK MFSAILRNEI GWFDKVDNTS SMLASRLESD ATLLRTIVVD
RSTILLENLG LVVTAFIISF ILNWRLTLVV LATYPLIISG HISEKIFMQG YGGNLSKAYL
KANMLAGESI SNIRTVVAFC AEEKVLDLYS KELLEPSERS FRRGQMAGIL YGVSQFFIFS
SYGLALWYGS ILMEKGLSSF ESVMKTFMVL IVTALVMGEV LALAPDLLKG NQMVVSVFEL
LDRRTQVVGD TGEELSNVEG TIELKGVHFS YPSRPDVTIF SDFNLLVPSG KSMALVGQSG
SGKSSVLSLV LRFYDPTAGI IMIDGQDIKK LKLKSLRRHI GLVQQEPALF ATTIYENILY
GKEGASESEV MEAAKLANAH SFISSLPEGY STKVGERGIQ MSGGQRQRIA IARAVLKNPE
ILLLDEATSA LDVESERVVQ QALDRLMRDR TTVVVAHRLS TIKNSDMISV IQDGKIIEQG
SHNILVENKN GPYSKLISLQ QRQRHHP
