AB11B_ARATH
ID AB11B_ARATH Reviewed; 1278 AA.
AC Q9FWX7;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=ABC transporter B family member 11;
DE Short=ABC transporter ABCB.11;
DE Short=AtABCB11;
DE AltName: Full=Multidrug resistance protein 8;
DE AltName: Full=P-glycoprotein 11;
GN Name=ABCB11; Synonyms=MDR8, PGP11; OrderedLocusNames=At1g02520;
GN ORFNames=T14P4.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
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DR EMBL; AC022521; AAG10628.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE27440.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60098.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM60099.1; -; Genomic_DNA.
DR PIR; E86155; E86155.
DR RefSeq; NP_001322407.1; NM_001331343.1.
DR RefSeq; NP_001322408.1; NM_001331342.1.
DR RefSeq; NP_171753.1; NM_100133.3.
DR AlphaFoldDB; Q9FWX7; -.
DR SMR; Q9FWX7; -.
DR BioGRID; 24588; 4.
DR STRING; 3702.AT1G02520.1; -.
DR iPTMnet; Q9FWX7; -.
DR PaxDb; Q9FWX7; -.
DR PRIDE; Q9FWX7; -.
DR ProteomicsDB; 245152; -.
DR EnsemblPlants; AT1G02520.1; AT1G02520.1; AT1G02520.
DR EnsemblPlants; AT1G02520.2; AT1G02520.2; AT1G02520.
DR EnsemblPlants; AT1G02520.3; AT1G02520.3; AT1G02520.
DR GeneID; 839353; -.
DR Gramene; AT1G02520.1; AT1G02520.1; AT1G02520.
DR Gramene; AT1G02520.2; AT1G02520.2; AT1G02520.
DR Gramene; AT1G02520.3; AT1G02520.3; AT1G02520.
DR KEGG; ath:AT1G02520; -.
DR Araport; AT1G02520; -.
DR TAIR; locus:2196145; AT1G02520.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; Q9FWX7; -.
DR OMA; MEGGSVM; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; Q9FWX7; -.
DR BioCyc; ARA:AT1G02520-MON; -.
DR PRO; PR:Q9FWX7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9FWX7; baseline and differential.
DR Genevisible; Q9FWX7; AT.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1278
FT /note="ABC transporter B family member 11"
FT /id="PRO_0000227919"
FT TRANSMEM 55..75
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 106..126
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 205..225
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 285..305
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 711..731
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 751..771
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 824..844
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 845..865
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 932..952
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 971..991
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 58..346
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 381..617
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 710..997
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1032..1271
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..35
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 629..656
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 8..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 416..423
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1067..1074
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 483
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 568
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 653
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 806
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1121
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1222
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1278 AA; 137667 MW; 169B26CCA975D7AD CRC64;
MNGDGAREGD SVSHEPSTSK SPKEGEETKK EEKSEEKANT VPFYKLFAFA DSSDVLLMIC
GSIGAIGNGM SLPFMTLLFG DLIDSFGKNQ NNKDIVDVVS KVCLKFVYLG LGTLGAAFLQ
VACWMITGER QAARIRSTYL KTILRQDIGF FDVETNTGEV VGRMSGDTVL IQDAMGEKVG
KFIQLVSTFV GGFVLAFIKG WLLTLVMLTS IPLLAMAGAA MALIVTRASS RGQAAYAKAA
TVVEQTIGSI RTVASFTGEK QAINSYKKFI TSAYKSSIQQ GFSTGLGLGV MFFVFFSSYA
LAIWFGGKMI LEKGYTGGAV INVIIIVVAG SMSLGQTSPC VTAFAAGQAA AYKMFETIKR
KPLIDAYDVN GKVLEDIRGD IELKDVHFSY PARPDEEIFD GFSLFIPSGA TAALVGESGS
GKSTVISLIE RFYDPKSGAV LIDGVNLKEF QLKWIRSKIG LVSQEPVLFS SSIMENIAYG
KENATVEEIK AATELANAAK FIDKLPQGLD TMVGEHGTQL SGGQKQRIAI ARAILKDPRI
LLLDEATSAL DAESERVVQE ALDRVMVNRT TVIVAHRLST VRNADMIAVI HRGKMVEKGS
HSELLKDSEG AYSQLIRLQE INKDVKTSEL SSGSSFRNSN LKKSMEGTSS VGNSSRHHSL
NVLGLTTGLD LGSHSQRAGQ DETGTASQEP LPKVSLTRIA ALNKPEIPVL LLGTVAAAIN
GAIFPLFGIL ISRVIEAFFK PAHELKRDSR FWAIIFVALG VTSLIVSPTQ MYLFAVAGGK
LIRRIRSMCF EKAVHMEVAW FDEPQNSSGT MGARLSADAT LIRALVGDAL SLAVQNVASA
ASGLIIAFTA SWELALIILV MLPLIGINGF VQVKFMKGFS ADAKSKYEEA SQVANDAVGS
IRTVASFCAE EKVMQMYKKQ CEGPIKDGIK QGFISGLGFG FSFFILFCVY ATSFYAGARL
VEDGKTTFNN VFQVFFALTM AAIGISQSST FAPDSSKAKV AAASIFAIID RKSKIDSSDE
TGTVLENVKG DIELRHLSFT YPARPDIQIF RDLCLTIRAG KTVALVGESG SGKSTVISLL
QRFYDPDSGH ITLDGVELKK LQLKWLRQQM GLVGQEPVLF NDTIRANIAY GKGSEEAATE
SEIIAAAELA NAHKFISSIQ QGYDTVVGER GIQLSGGQKQ RVAIARAIVK EPKILLLDEA
TSALDAESER VVQDALDRVM VNRTTIVVAH RLSTIKNADV IAVVKNGVIA EKGTHETLIK
IEGGVYASLV QLHMTASN
