AB11C_ARATH
ID AB11C_ARATH Reviewed; 1495 AA.
AC Q9C8H1; Q9S9R0;
DT 07-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 07-MAR-2006, sequence version 2.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=ABC transporter C family member 11;
DE Short=ABC transporter ABCC.11;
DE Short=AtABCC11;
DE EC=7.6.2.2;
DE AltName: Full=ATP-energized glutathione S-conjugate pump 12;
DE AltName: Full=Glutathione S-conjugate-transporting ATPase 12;
DE AltName: Full=Multidrug resistance-associated protein 12;
GN Name=ABCC11; Synonyms=MRP11, MRP12; OrderedLocusNames=At1g30420;
GN ORFNames=F26G16.1, T4K22.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY.
RX PubMed=11855639; DOI=10.1007/s004250100661;
RA Martinoia E., Klein M., Geisler M., Bovet L., Forestier C.,
RA Kolukisaoglu H.U., Mueller-Roeber B., Schulz B.;
RT "Multifunctionality of plant ABC transporters -- more than just
RT detoxifiers.";
RL Planta 214:345-355(2002).
RN [5]
RP TISSUE SPECIFICITY.
RX PubMed=12430019; DOI=10.1007/s00425-002-0890-6;
RA Kolukisaoglu U.H., Bovet L., Klein M., Eggmann T., Geisler M., Wanke D.,
RA Martinoia E., Schulz B.;
RT "Family business: the multidrug-resistance related protein (MRP) ABC
RT transporter genes in Arabidopsis thaliana.";
RL Planta 216:107-119(2002).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- FUNCTION: Pump for glutathione S-conjugates. {ECO:0000250}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O + xenobioticSide 1 = ADP + phosphate +
CC xenobioticSide 2.; EC=7.6.2.2;
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:12430019}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF19743.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAG51094.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC009917; AAF19743.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC025295; AAG51094.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE31215.1; -; Genomic_DNA.
DR PIR; F86428; F86428.
DR RefSeq; NP_001319112.1; NM_001332898.1.
DR AlphaFoldDB; Q9C8H1; -.
DR SMR; Q9C8H1; -.
DR STRING; 3702.AT1G30420.1; -.
DR PaxDb; Q9C8H1; -.
DR PRIDE; Q9C8H1; -.
DR ProteomicsDB; 243293; -.
DR EnsemblPlants; AT1G30420.1; AT1G30420.1; AT1G30420.
DR GeneID; 839922; -.
DR Gramene; AT1G30420.1; AT1G30420.1; AT1G30420.
DR KEGG; ath:AT1G30420; -.
DR Araport; AT1G30420; -.
DR TAIR; locus:2028155; AT1G30420.
DR eggNOG; KOG0054; Eukaryota.
DR HOGENOM; CLU_000604_27_6_1; -.
DR InParanoid; Q9C8H1; -.
DR OMA; ICALETD; -.
DR OrthoDB; 138195at2759; -.
DR PhylomeDB; Q9C8H1; -.
DR BioCyc; ARA:AT1G30420-MON; -.
DR PRO; PR:Q9C8H1; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C8H1; baseline and differential.
DR Genevisible; Q9C8H1; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IBA:GO_Central.
DR GO; GO:0008559; F:ABC-type xenobiotic transporter activity; IEA:UniProtKB-EC.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; ISS:TAIR.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR Gene3D; 1.20.1560.10; -; 2.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR044746; ABCC_6TM_D1.
DR InterPro; IPR044726; ABCC_6TM_D2.
DR InterPro; IPR027417; P-loop_NTPase.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW Translocase; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1495
FT /note="ABC transporter C family member 11"
FT /id="PRO_0000226083"
FT TRANSMEM 32..52
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 76..96
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 110..130
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 146..166
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 182..202
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 337..357
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 420..440
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 441..461
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 528..548
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 907..927
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 949..969
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1042..1062
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1142..1162
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 1166..1186
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 303..583
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 615..839
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 914..1198
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1235..1469
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 650..657
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1269..1276
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 1495 AA; 168104 MW; 9318F5DC045C35F2 CRC64;
MGFEALNWYC KPIAEGFWEK TPDGAFGAYT PCAIDSLVMI VSNSVLLGLC FYRIWITLYN
AKAQIYVLRK MYYHCVLWIL ACCCVVEPVL RLVMGISLFD MGDETDLPPF EVASLMVEAF
AWFAMLVLIG LETKQYVKEF RWYVRFGVVY VLVADAVLLD LVLPLKNSIN RTALYLCISS
RCCQALFGIL LLVYIPELDL YPDYHILNNE SLDNVEYDAL PGGVNICPER YASIFSGIYF
SWMTPLMQLG YRKPITERDV WQLDQWDQTE TLIKRFQRCW TEESRRPKPW LLRALNNSLG
RRFWLGGIFK VGHDLSQFVG PVILSHILQS MIEGDPAWVG YVYAFLIFFG VTFGVLCQSQ
YFQHVGRVGF RLRSTLVAAI FHKSLRLTNK ARKNFASGKV TNMITTDANA LQLIAEQLHG
LWSAPFRIIV SMVLLYQQLG VASIFGSLIL FLLIPFQTLI VRKMRKLTKE GLQWTDKRVG
IIYEILASMD IVKCYAWEKS FESRIQGIRN EELSWFRKAQ LLSAFNSFIL NSTPVVVTLV
SFGVYVLLGG DLTPARAFTS LSLFAVLRSP LSTLPNLISQ AVNANVSLQR IEELLLSEER
ILAQNPPLQP GAPAISIKNG YFSWDSKTSK PTLSDINLEI PVGSLVAIVG GTGEGKTSLI
SAMLGELSHA ETSSVDIRGS VAYVPQVSWI FNATLRENIL FGSDFESERY WRAIDVTALQ
HDLDLFPGRD RTEIGERGVN ISGGQKQRVS MARAVYSNSD IYIFDDPFSA LDAHVAHQVF
DSCVKHELKG KTRVLVTNQL HFLPLMDRII LVSEGMIKEE GNFAELSKSG TLFKKLMENA
GKMDATQEVN TNDENISKLG PTVTIDVSER SLGSIQQGKW GRSMLVKQEE RETGIISWDV
VMRYNKAVGG LWVVMILLVC YLTTEVLRVL SSTWLSIWTD QSTPKSYSPG FYIVVYALLG
FGQVAVTFTN SFWLISSSLH AAKRLHDAML NSILRAPMLF FETNPTGRVI NRFSKDIGDI
DRNVANLMNM FMNQLWQLLS TFALIGIVST ISLWAIMPLL ILFYATYIYY QSTSREVRRL
DSVTRSPIYA LFGEALNGLS SIRAYKAYDR MAKINGKSMD NNIRFTLAST SSNRWLTIRS
ESLGGVMIWL TATFAVLRYG NAENQAVFAS TMGLLLSYTL NITTLLSGVL RQASKAENSL
NSVERVGNYI DLPSEATAII ENNRPVSGWP SRGSIQFEDV HLRYRPGLPP VLHGLSFFVY
PSEKVGVVGR TGAGKSSMLN ALYRIVELEK GRILIDDYDV AKFGLTDLRR VLSIIPQSPV
LFSGTVRFNI DPFSEHNDAD LWEALERAHI KDVIDRNPFG LDAEVSEGGE NFSVGQRQLL
SLARALLRRS KILFLDEATA SVDVRTDSLI QRTIREEFKS CTMLIIAHRL NTIIDCDKIL
VLSSGQVLEY DSPQELLSRD TSAFFKMVHS TGPENGQYLS NLVFERRGNG MSQGG
