ID   RLA0_CULNU              Reviewed;          78 AA.
AC   Q9BMP6;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   25-MAY-2022, entry version 49.
DE   RecName: Full=60S acidic ribosomal protein P0 {ECO:0000305};
DE   AltName: Full=Ribosomal P0 protein {ECO:0000303|PubMed:15113658};
DE   AltName: Allergen=Cul n 1 {ECO:0000303|PubMed:15113658};
DE   Flags: Fragment;
OS   Culicoides nubeculosus (Biting midge).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Diptera; Nematocera; Chironomoidea;
OC   Ceratopogonidae; Ceratopogoninae; Culicoides; Monoculicoides.
OX   NCBI_TaxID=144565 {ECO:0000312|EMBL:AAK00899.1};
RN   [1] {ECO:0000312|EMBL:AAK00899.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RX   PubMed=15113658; DOI=10.1016/j.vetimm.2004.01.011;
RA   Althaus H., Muller N., Busato A., Mellor P.S., Torsteinsdottir S.,
RA   Marti E.;
RT   "Cloning and sequencing of a cDNA expressing a ribosomal P0 peptide from
RT   Culicoides nubeculosus (Diptera).";
RL   Vet. Immunol. Immunopathol. 99:99-111(2004).
CC   -!- FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli
CC       protein L10. {ECO:0000305}.
CC   -!- SUBUNIT: P0 forms a pentameric complex by interaction with dimers of P1
CC       and P2. {ECO:0000250|UniProtKB:P05388}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:P05388}. Cytoplasm
CC       {ECO:0000250|UniProtKB:P05388}.
CC   -!- ALLERGEN: Causes an allergic reaction in horses. Binds to IgE of 19
CC       horses from Switzerland suffering from insect bite hypersensitivity
CC       (IBH), a recurrent seasonal dermatitis of the horse, caused by bites of
CC       Culicoides (midge) and sometimes Simulium (black fly) species. Binds to
CC       IgE of all 18 healthy control horses from Switzerland exposed to the
CC       bites of these insects, and of 8 horses from Iceland which had not been
CC       exposed to Culicoides midges. There is no significant difference in
CC       IgE-binding between the three groups of horses. Does not induce
CC       sulfidoleukotriene (sLT) release from peripheral blood leukocytes
CC       (PBLs) in any of the 5 horses tested affected by IBH.
CC       {ECO:0000269|PubMed:15113658}.
CC   -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC       {ECO:0000305}.
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DR   EMBL; AF314650; AAK00899.1; -; mRNA.
DR   AlphaFoldDB; Q9BMP6; -.
DR   SMR; Q9BMP6; -.
DR   Allergome; 1352; Cul n 1.
DR   GO; GO:0005737; C:cytoplasm; ISS:UniProtKB.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Nucleus; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           <1..78
FT                   /note="60S acidic ribosomal protein P0"
FT                   /id="PRO_0000447854"
FT   REGION          40..78
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        50..64
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
FT                   /evidence="ECO:0000312|EMBL:AAK00899.1"
SQ   SEQUENCE   78 AA;  8372 MW;  A2C63F35E38F124A CRC64;
     APHSIANGFK NLLALAATTD VDSKEAETIK EYIKDPSKIA AAAAATAPAA ETKKEEKKEE
     KKEETEESDD DIGLSLFH