RLA0_DICDI
ID RLA0_DICDI Reviewed; 305 AA.
AC P22685; Q54LP0;
DT 01-AUG-1991, integrated into UniProtKB/Swiss-Prot.
DT 04-DEC-2007, sequence version 2.
DT 25-MAY-2022, entry version 126.
DE RecName: Full=60S acidic ribosomal protein P0;
GN Name=rplp0; ORFNames=DDB_G0286501;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=AX3;
RX PubMed=2030951; DOI=10.1093/nar/19.6.1342;
RA Prieto J., Candel E., Coloma A.;
RT "Nucleotide sequence of a cDNA encoding ribosomal protein P0 in
RT Dictyostelium discoideum.";
RL Nucleic Acids Res. 19:1342-1342(1991).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC STRAIN=AX2;
RX PubMed=16926386; DOI=10.1074/mcp.m600113-mcp200;
RA Gotthardt D., Blancheteau V., Bosserhoff A., Ruppert T., Delorenzi M.,
RA Soldati T.;
RT "Proteomics fingerprinting of phagosome maturation and evidence for the
RT role of a Galpha during uptake.";
RL Mol. Cell. Proteomics 5:2228-2243(2006).
CC -!- FUNCTION: Ribosomal protein P0 is the functional equivalent of E.coli
CC protein L10.
CC -!- SUBUNIT: P0 forms a pentameric complex by interaction with dimers of P1
CC and P2.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the universal ribosomal protein uL10 family.
CC {ECO:0000305}.
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DR EMBL; X56194; CAA39657.1; -; mRNA.
DR EMBL; AAFI02000087; EAL64177.1; -; Genomic_DNA.
DR PIR; S14012; R5DOP0.
DR RefSeq; XP_637692.1; XM_632600.1.
DR PDB; 5AN9; EM; 3.30 A; C=1-205.
DR PDB; 5ANB; EM; 4.10 A; C=1-205.
DR PDB; 5ANC; EM; 4.20 A; C=1-205.
DR PDB; 6QKL; EM; 3.30 A; C=1-205.
DR PDBsum; 5AN9; -.
DR PDBsum; 5ANB; -.
DR PDBsum; 5ANC; -.
DR PDBsum; 6QKL; -.
DR AlphaFoldDB; P22685; -.
DR SMR; P22685; -.
DR STRING; 44689.DDB0219977; -.
DR PaxDb; P22685; -.
DR EnsemblProtists; EAL64177; EAL64177; DDB_G0286501.
DR GeneID; 8625658; -.
DR KEGG; ddi:DDB_G0286501; -.
DR dictyBase; DDB_G0286501; rplP0.
DR eggNOG; KOG0815; Eukaryota.
DR HOGENOM; CLU_053173_1_1_1; -.
DR InParanoid; P22685; -.
DR OMA; MAHVAEW; -.
DR PhylomeDB; P22685; -.
DR Reactome; R-DDI-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-DDI-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-DDI-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-DDI-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-DDI-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-DDI-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P22685; -.
DR Proteomes; UP000002195; Chromosome 4.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IBA:GO_Central.
DR GO; GO:0031012; C:extracellular matrix; HDA:dictyBase.
DR GO; GO:0005811; C:lipid droplet; HDA:dictyBase.
DR GO; GO:0045335; C:phagocytic vesicle; HDA:dictyBase.
DR GO; GO:0070180; F:large ribosomal subunit rRNA binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; IBA:GO_Central.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0000027; P:ribosomal large subunit assembly; IBA:GO_Central.
DR Gene3D; 3.30.70.1730; -; 1.
DR Gene3D; 3.90.105.20; -; 1.
DR InterPro; IPR030670; L10E_eukaryotes.
DR InterPro; IPR043141; Ribosomal_L10-like_sf.
DR InterPro; IPR001790; Ribosomal_L10P.
DR InterPro; IPR043164; RL10_insert_sf.
DR InterPro; IPR040637; RL10P_insert.
DR Pfam; PF00466; Ribosomal_L10; 1.
DR Pfam; PF17777; RL10P_insert; 1.
DR PIRSF; PIRSF039087; L10E; 1.
DR SUPFAM; SSF160369; SSF160369; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..305
FT /note="60S acidic ribosomal protein P0"
FT /id="PRO_0000154768"
FT CONFLICT 10..11
FT /note="NV -> KL (in Ref. 1; CAA39657)"
FT /evidence="ECO:0000305"
FT CONFLICT 271
FT /note="A -> R (in Ref. 1; CAA39657)"
FT /evidence="ECO:0000305"
FT CONFLICT 280
FT /note="A -> R (in Ref. 1; CAA39657)"
FT /evidence="ECO:0000305"
FT TURN 5..8
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 9..18
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 24..30
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 39..41
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 42..44
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 45..49
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 50..52
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 65..67
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 73..78
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 80..83
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 85..92
FT /evidence="ECO:0007829|PDB:5AN9"
FT TURN 96..99
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 100..103
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 125..128
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 134..139
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 140..142
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 148..152
FT /evidence="ECO:0007829|PDB:5AN9"
FT HELIX 168..176
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 183..192
FT /evidence="ECO:0007829|PDB:5AN9"
FT STRAND 194..196
FT /evidence="ECO:0007829|PDB:5AN9"
SQ SEQUENCE 305 AA; 32853 MW; 6C8EAD931C66E594 CRC64;
MSGAGSKRKN VFIEKATKLF TTYDKMIVAE ADFVGSSQLQ KIRKSIRGIG AVLMGKKTMI
RKVIRDLADS KPELDALNTY LKQNTCIIFC KDNIAEVKRV INTQRVGAPA KAGVFAPNDV
IIPAGPTGME PTQTSFLQDL KIATKINRGQ IDIVNEVHII KTGQKVGASE ATLLQKLNIK
PFTYGLEPKI IYDAGACYSP SISEEDLINK FKQGIFNIAA ISLEIGYPTV ASIPHSVMNA
FKNLLAISFE TSYTFDAAEK FKSAAAAAPV AAAPSAAAPA AAAKKVVVEE KKEESDDDMG
MGLFD
