ID   RLA1_PENBR              Reviewed;         107 AA.
AC   Q49KL9;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=60S acidic ribosomal protein P1 {ECO:0000303|PubMed:16088208, ECO:0000303|PubMed:19248220, ECO:0000303|PubMed:23902156};
DE   AltName: Allergen=Pen b 26.0101 {ECO:0000305};
OS   Penicillium brevicompactum.
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Eurotiomycetes;
OC   Eurotiomycetidae; Eurotiales; Aspergillaceae; Penicillium.
OX   NCBI_TaxID=5074 {ECO:0000312|EMBL:AAX11194.1};
RN   [1] {ECO:0000312|EMBL:AAX11194.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND ALLERGEN.
RC   TISSUE=Mycelium {ECO:0000303|PubMed:16088208};
RX   PubMed=16088208; DOI=10.1159/000087353;
RA   Sevinc M.S., Kumar V., Abebe M., Casley W.L., Vijay H.M.;
RT   "Isolation and characterization of a cDNA clone encoding one IgE-binding
RT   fragment of Penicillium brevicompactum.";
RL   Int. Arch. Allergy Immunol. 138:12-20(2005).
RN   [2] {ECO:0000312|EMBL:AAX11194.1}
RP   ALLERGEN.
RX   PubMed=19248220; DOI=10.1016/j.pep.2009.01.004;
RA   Sevinc M.S., Kumar V., Abebe M., Mohottalage S., Kumarathasan P.,
RA   Vincent R., Vijay H.M.;
RT   "Expression and characterization of Pen b 26 allergen of Penicillium
RT   brevicompactum in Escherichia coli.";
RL   Protein Expr. Purif. 65:8-14(2009).
RN   [3]
RP   ALLERGEN.
RX   PubMed=23902156; DOI=10.3109/13693786.2013.813086;
RA   Sevinc M.S., Kumar V., Abebe M., Lemieux M., Vijay H.M.;
RT   "Isolation, expression and characterization of a minor allergen from
RT   Penicillium crustosum.";
RL   Med. Mycol. 52:81-89(2013).
CC   -!- FUNCTION: Plays an important role in the elongation step of protein
CC       synthesis. {ECO:0000305}.
CC   -!- SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
CC       {ECO:0000305}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:P05318}.
CC   -!- ALLERGEN: Causes an allergic reaction in human (PubMed:16088208,
CC       PubMed:19248220, PubMed:23902156). Binds to IgE of patients allergic to
CC       mold P.brevicompactum (PubMed:16088208). Binds to IgE in 73% of the 41
CC       Penicillium-sensitive patients tested (PubMed:19248220). Binds to IgE
CC       in 87% of the 61 patients tested allergic to Penicillium mold
CC       (PubMed:23902156). {ECO:0000269|PubMed:16088208,
CC       ECO:0000269|PubMed:19248220, ECO:0000269|PubMed:23902156}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC       {ECO:0000305}.
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DR   EMBL; AY786077; AAX11194.1; -; mRNA.
DR   AlphaFoldDB; Q49KL9; -.
DR   SMR; Q49KL9; -.
DR   Allergome; 2486; Pen b 26.
DR   Allergome; 3400; Pen b 26.0101.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; ISS:UniProtKB.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISS:UniProtKB.
DR   GO; GO:0002181; P:cytoplasmic translation; ISS:UniProtKB.
DR   GO; GO:0006414; P:translational elongation; IEA:InterPro.
DR   Gene3D; 1.10.10.1410; -; 1.
DR   HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR   InterPro; IPR038716; P1/P2_N_sf.
DR   InterPro; IPR027534; Ribosomal_L12/P1/P2.
PE   1: Evidence at protein level;
KW   Allergen; Cytoplasm; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..107
FT                   /note="60S acidic ribosomal protein P1"
FT                   /id="PRO_0000447994"
FT   REGION          68..107
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        91..107
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   107 AA;  11066 MW;  772D63BC701CA124 CRC64;
     MSTAELAVSY AALILADDGI EVSADKIQTI LGAAKVQEVE PIWATIFAKA LEGKDIKEIL
     TNVGSAGPAT AGAPAAAGAA APAEEKKEEK EEEKEESDED MGFGLFD