ID   RLA1_SCHPO              Reviewed;         109 AA.
AC   P17476;
DT   01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1990, sequence version 1.
DT   03-AUG-2022, entry version 151.
DE   RecName: Full=60S acidic ribosomal protein P1-alpha 1;
DE            Short=A1;
GN   Name=rpp101; Synonyms=rpa1; ORFNames=SPAC644.15;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=2325655; DOI=10.1128/mcb.10.5.2341-2348.1990;
RA   Beltrame M., Bianchi M.E.;
RT   "A gene family for acidic ribosomal proteins in Schizosaccharomyces pombe:
RT   two essential and two nonessential genes.";
RL   Mol. Cell. Biol. 10:2341-2348(1990).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8194753; DOI=10.1016/0378-1119(94)90262-3;
RA   Jang Y.K., Jin Y.H., Kim E.M., Hong S.H., Fabre F., Park S.D.;
RT   "Cloning and sequence analysis of rhp51+, a Schizosaccharomyces pombe
RT   homolog of the Saccharomyces cerevisiae RAD51 gene.";
RL   Gene 142:207-211(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-24.
RX   PubMed=8233794; DOI=10.1093/nar/21.19.4586;
RA   Muris D.F.R., Vreeken K., Carr A.M., Broughton B.C., Lehmann A.R.,
RA   Lohman P.H.M., Pastink A.;
RT   "Cloning the RAD51 homologue of Schizosaccharomyces pombe.";
RL   Nucleic Acids Res. 21:4586-4591(1993).
CC   -!- FUNCTION: Plays an important role in the elongation step of protein
CC       synthesis.
CC   -!- SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
CC   -!- MISCELLANEOUS: Yeasts contain 4 individual small ribosomal A proteins
CC       (RPA) which can be classified into two couples of similar but not
CC       identical sequences. Each couple is distinctly related to one of the
CC       two A proteins present in multicellular organisms.
CC   -!- MISCELLANEOUS: Rpa3 and rpa4 are essential for cell survival, whereas
CC       rpa1 and rpa2 are not.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC       {ECO:0000305}.
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DR   EMBL; M33137; AAA35334.1; -; Genomic_DNA.
DR   EMBL; Z24756; CAA80880.2; ALT_SEQ; Genomic_DNA.
DR   EMBL; CU329670; CAB90142.1; -; Genomic_DNA.
DR   EMBL; Z22691; CAA80400.1; -; Genomic_DNA.
DR   PIR; A34715; R6BY11.
DR   RefSeq; NP_593883.1; NM_001019313.2.
DR   AlphaFoldDB; P17476; -.
DR   BioGRID; 279645; 2.
DR   STRING; 4896.SPAC644.15.1; -.
DR   iPTMnet; P17476; -.
DR   MaxQB; P17476; -.
DR   PaxDb; P17476; -.
DR   PRIDE; P17476; -.
DR   EnsemblFungi; SPAC644.15.1; SPAC644.15.1:pep; SPAC644.15.
DR   GeneID; 2543217; -.
DR   KEGG; spo:SPAC644.15; -.
DR   PomBase; SPAC644.15; rpp101.
DR   VEuPathDB; FungiDB:SPAC644.15; -.
DR   eggNOG; KOG1762; Eukaryota.
DR   HOGENOM; CLU_114656_1_0_1; -.
DR   OMA; VESYWPT; -.
DR   PhylomeDB; P17476; -.
DR   Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:P17476; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; ISO:PomBase.
DR   GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR   GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR   GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR   GO; GO:0002182; P:cytoplasmic translational elongation; ISO:PomBase.
DR   Gene3D; 1.10.10.1410; -; 1.
DR   HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR   InterPro; IPR038716; P1/P2_N_sf.
DR   InterPro; IPR027534; Ribosomal_L12/P1/P2.
PE   3: Inferred from homology;
KW   Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT   CHAIN           1..109
FT                   /note="60S acidic ribosomal protein P1-alpha 1"
FT                   /id="PRO_0000157707"
FT   REGION          69..109
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        89..109
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        24
FT                   /note="S -> V (in Ref. 4; CAA80400)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   109 AA;  11141 MW;  2C5878183226AA04 CRC64;
     MSASELATSY SALILADEGI EITSDKLLSL TKAANVDVEP IWATIFAKAL EGKDLKELLL
     NIGSGAGAAP VAGGAAAPAA ADGEAPAEEK EEAKEEEESD EDMGFGLFD