RLA2_TRYCR
ID RLA2_TRYCR Reviewed; 107 AA.
AC P23632;
DT 01-NOV-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1991, sequence version 1.
DT 25-MAY-2022, entry version 74.
DE RecName: Full=60S acidic ribosomal protein P2-A;
DE Short=P;
DE AltName: Full=L12E;
DE AltName: Full=P-JL5;
OS Trypanosoma cruzi.
OC Eukaryota; Discoba; Euglenozoa; Kinetoplastea; Metakinetoplastina;
OC Trypanosomatida; Trypanosomatidae; Trypanosoma; Schizotrypanum.
OX NCBI_TaxID=5693;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Tulahuen 2;
RX PubMed=2192363; DOI=10.1093/nar/18.11.3399;
RA Schijman A.G., Dusetti N.J., Vazquez M.P., Lafon S., Levy-Yeyati P.,
RA Levin M.J.;
RT "Nucleotide cDNA and complete deduced amino acid sequence of a Trypanosoma
RT cruzi ribosomal P protein (P-JL5).";
RL Nucleic Acids Res. 18:3399-3399(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=Tulahuen;
RX PubMed=7935610; DOI=10.1016/0166-6851(94)00026-3;
RA Vazquez M.P., Schijman A.G., Levin M.J.;
RT "A short interspersed repetitive element provides a new 3' acceptor site
RT for trans-splicing in certain ribosomal P2 beta protein genes of
RT Trypanosoma cruzi.";
RL Mol. Biochem. Parasitol. 64:327-336(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 3-107.
RX PubMed=1723150; DOI=10.1016/0166-6851(91)90076-i;
RA Nafziger D.F., Recinos R.F., Hunter C., Donelson J.E.;
RT "Patients infected with Leishmania donovani chagasi can have antibodies
RT that recognize heat shock and acidic ribosomal proteins of Trypanosoma
RT cruzi.";
RL Mol. Biochem. Parasitol. 49:325-328(1991).
RN [4]
RP PROTEIN SEQUENCE OF 97-107.
RX PubMed=2479275; DOI=10.4269/ajtmh.1989.41.530;
RA Levin M.J., Mesri E., Benarous R., Levitus G., Schijman A., Levy-Yeyati P.,
RA Chiale P.A., Ruiz A.M., Kahn A., Rosenbaum M.B., Torres H.N., Segura E.L.;
RT "Identification of major Trypanosoma cruzi antigenic determinants in
RT chronic Chagas' heart disease.";
RL Am. J. Trop. Med. Hyg. 41:530-538(1989).
RN [5]
RP VARIANTS.
RX PubMed=7578249; DOI=10.1016/0167-4781(95)00142-4;
RA Schijman A.G., Vazquez M.P., Dov C.B., Ghio S., Lorenzi H., Levin M.J.;
RT "Cloning and sequence analysis of the TcP2 beta cDNA variants of
RT Trypanosoma cruzi.";
RL Biochim. Biophys. Acta 1264:15-18(1995).
CC -!- FUNCTION: Plays an important role in the elongation step of protein
CC synthesis.
CC -!- SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
CC -!- PTM: Phosphorylated. {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; X52323; CAA36557.1; -; mRNA.
DR EMBL; X69508; CAA49260.1; -; mRNA.
DR EMBL; X69509; CAA49261.1; -; mRNA.
DR EMBL; X69510; CAA49262.1; -; mRNA.
DR EMBL; X75030; CAA52938.1; -; Genomic_DNA.
DR EMBL; M72710; AAA30210.1; -; mRNA.
DR PIR; A45641; A45641.
DR PIR; S12585; R5UT2E.
DR PIR; S31435; S31435.
DR PIR; S59918; S59918.
DR PIR; S59919; S59919.
DR AlphaFoldDB; P23632; -.
DR SMR; P23632; -.
DR ABCD; P23632; 2 sequenced antibodies.
DR VEuPathDB; TriTrypDB:BCY84_01209; -.
DR VEuPathDB; TriTrypDB:C4B63_247g120c; -.
DR VEuPathDB; TriTrypDB:TcBrA4_0027130; -.
DR VEuPathDB; TriTrypDB:TcCL_ESM00973; -.
DR VEuPathDB; TriTrypDB:TcCLB.509165.40; -.
DR VEuPathDB; TriTrypDB:TcCLB.510643.140; -.
DR VEuPathDB; TriTrypDB:TcG_00931; -.
DR OMA; AYLMNVL; -.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0002182; P:cytoplasmic translational elongation; IEA:InterPro.
DR CDD; cd05833; Ribosomal_P2; 1.
DR DisProt; DP00845; -.
DR Gene3D; 1.10.10.1410; -; 1.
DR HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR InterPro; IPR038716; P1/P2_N_sf.
DR InterPro; IPR027534; Ribosomal_L12/P1/P2.
DR InterPro; IPR044076; Ribosomal_P2.
DR InterPro; IPR001859; T.cruzi_P2-like.
DR PANTHER; PTHR21141; PTHR21141; 1.
DR PRINTS; PR00456; RIBOSOMALP2.
PE 1: Evidence at protein level;
KW Direct protein sequencing; Phosphoprotein; Ribonucleoprotein;
KW Ribosomal protein.
FT CHAIN 1..107
FT /note="60S acidic ribosomal protein P2-A"
FT /id="PRO_0000157668"
FT REGION 85..107
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 92..107
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 31..32
FT /note="VP -> A (in variant A)"
FT VARIANT 43
FT /note="A -> T (in variant E)"
FT VARIANT 46
FT /note="A -> S (in variant D)"
FT VARIANT 50
FT /note="F -> L (in variant A)"
FT VARIANT 55
FT /note="T -> A (in variant C)"
FT VARIANT 65
FT /note="V -> A (in variant A)"
FT VARIANT 66
FT /note="T -> A (in variant C)"
FT VARIANT 84
FT /note="S -> G (in variant C)"
FT VARIANT 92
FT /note="A -> T (in variant E)"
FT CONFLICT 28
FT /note="A -> T (in Ref. 3; AAA30210)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 107 AA; 10512 MW; D34DD51CDB82BBF5 CRC64;
MKYLAAYALV GLSGGTPSKS AVEAVLKAAG VPVDPSRVDA LFAEFAGKDF DTVCTEGKSK
LVGGVTRPNA ATASAPTAAA AASSGAAAPA AAAEEEEDDD MGFGLFD
