RLA3_SCHPO
ID RLA3_SCHPO Reviewed; 110 AA.
AC P17477;
DT 01-AUG-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1990, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=60S acidic ribosomal protein P1-alpha 3;
DE Short=A3;
GN Name=rpp102; Synonyms=rpa3; ORFNames=SPBC3B9.13c;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=2325655; DOI=10.1128/mcb.10.5.2341-2348.1990;
RA Beltrame M., Bianchi M.E.;
RT "A gene family for acidic ribosomal proteins in Schizosaccharomyces pombe:
RT two essential and two nonessential genes.";
RL Mol. Cell. Biol. 10:2341-2348(1990).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
CC -!- FUNCTION: Plays an important role in the elongation step of protein
CC synthesis.
CC -!- SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
CC -!- MISCELLANEOUS: Yeasts contain 4 individual small ribosomal A proteins
CC (RPA) which can be classified into two couples of similar but not
CC identical sequences. Each couple is distinctly related to one of the
CC two A proteins present in multicellular organisms.
CC -!- MISCELLANEOUS: Rpa3 and rpa4 are essential for cell survival, whereas
CC rpa1 and rpa2 are not.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC {ECO:0000305}.
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DR EMBL; M33139; AAA35336.1; -; Genomic_DNA.
DR EMBL; CU329671; CAA17793.1; -; Genomic_DNA.
DR PIR; C34715; R6BYP3.
DR RefSeq; NP_596671.1; NM_001022593.2.
DR AlphaFoldDB; P17477; -.
DR BioGRID; 276830; 5.
DR STRING; 4896.SPBC3B9.13c.1; -.
DR iPTMnet; P17477; -.
DR MaxQB; P17477; -.
DR PaxDb; P17477; -.
DR PRIDE; P17477; -.
DR EnsemblFungi; SPBC3B9.13c.1; SPBC3B9.13c.1:pep; SPBC3B9.13c.
DR GeneID; 2540299; -.
DR KEGG; spo:SPBC3B9.13c; -.
DR PomBase; SPBC3B9.13c; rpp102.
DR VEuPathDB; FungiDB:SPBC3B9.13c; -.
DR eggNOG; KOG1762; Eukaryota.
DR HOGENOM; CLU_114656_1_0_1; -.
DR InParanoid; P17477; -.
DR OMA; TDVEPIW; -.
DR PhylomeDB; P17477; -.
DR Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR PRO; PR:P17477; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0022625; C:cytosolic large ribosomal subunit; ISO:PomBase.
DR GO; GO:0030295; F:protein kinase activator activity; IBA:GO_Central.
DR GO; GO:0043021; F:ribonucleoprotein complex binding; IBA:GO_Central.
DR GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR GO; GO:0002181; P:cytoplasmic translation; IBA:GO_Central.
DR GO; GO:0002182; P:cytoplasmic translational elongation; ISO:PomBase.
DR Gene3D; 1.10.10.1410; -; 1.
DR HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR InterPro; IPR038716; P1/P2_N_sf.
DR InterPro; IPR027534; Ribosomal_L12/P1/P2.
PE 3: Inferred from homology;
KW Phosphoprotein; Reference proteome; Ribonucleoprotein; Ribosomal protein.
FT CHAIN 1..110
FT /note="60S acidic ribosomal protein P1-alpha 3"
FT /id="PRO_0000157708"
FT REGION 69..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 91..110
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 110 AA; 11171 MW; 1734AC9779F5A891 CRC64;
MSASELATSY SALILADEGI EITSDKLLSL TKAANVDVEP IWATIFAKAL EGKDLKELLL
NIGSAAAAPA AGGAGAPAAA AGGEAAAEEQ KEEAKEEEES DEDMGFGLFD
