ID   RLA6_SCHPO              Reviewed;         110 AA.
AC   O14317;
DT   10-JUN-2008, integrated into UniProtKB/Swiss-Prot.
DT   01-AUG-1998, sequence version 2.
DT   03-AUG-2022, entry version 132.
DE   RecName: Full=60S acidic ribosomal protein P2-C;
GN   Name=rpp203; Synonyms=rla6, rpp2-3; ORFNames=SPAC1071.08;
OS   Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC   Schizosaccharomyces.
OX   NCBI_TaxID=284812;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=9649613; DOI=10.1093/nar/26.14.3319;
RA   Gross T., Kaufer N.F.;
RT   "Cytoplasmic ribosomal protein genes of the fission yeast
RT   Schizosaccharomyces pombe display a unique promoter type: a suggestion for
RT   nomenclature of cytoplasmic ribosomal proteins in databases.";
RL   Nucleic Acids Res. 26:3319-3322(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=972 / ATCC 24843;
RX   PubMed=11859360; DOI=10.1038/nature724;
RA   Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA   Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA   Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA   Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA   Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA   Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA   Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA   Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA   O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA   Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA   Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA   Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA   Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA   Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA   Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA   Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA   Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA   Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA   Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA   Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA   del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA   Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA   Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA   Nurse P.;
RT   "The genome sequence of Schizosaccharomyces pombe.";
RL   Nature 415:871-880(2002).
RN   [3]
RP   SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX   PubMed=16823372; DOI=10.1038/nbt1222;
RA   Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA   Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA   Yoshida M.;
RT   "ORFeome cloning and global analysis of protein localization in the fission
RT   yeast Schizosaccharomyces pombe.";
RL   Nat. Biotechnol. 24:841-847(2006).
RN   [4]
RP   PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-100, AND IDENTIFICATION BY
RP   MASS SPECTROMETRY.
RX   PubMed=18257517; DOI=10.1021/pr7006335;
RA   Wilson-Grady J.T., Villen J., Gygi S.P.;
RT   "Phosphoproteome analysis of fission yeast.";
RL   J. Proteome Res. 7:1088-1097(2008).
CC   -!- FUNCTION: Plays an important role in the elongation step of protein
CC       synthesis. {ECO:0000250}.
CC   -!- SUBUNIT: P1 and P2 exist as dimers at the large ribosomal subunit.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000269|PubMed:16823372}.
CC   -!- MISCELLANEOUS: Yeasts contain 4 individual small ribosomal A proteins
CC       (RPA) which can be classified into two couples of similar but not
CC       identical sequences. Each couple is distinctly related to one of the
CC       two A proteins present in multicellular organisms.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein P1/P2 family.
CC       {ECO:0000305}.
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DR   EMBL; AJ002734; CAA05696.1; -; mRNA.
DR   EMBL; CU329670; CAB59884.1; -; Genomic_DNA.
DR   PIR; T37490; T37490.
DR   RefSeq; NP_594358.1; NM_001019779.2.
DR   AlphaFoldDB; O14317; -.
DR   SMR; O14317; -.
DR   BioGRID; 279486; 27.
DR   STRING; 4896.SPAC1071.08.1; -.
DR   iPTMnet; O14317; -.
DR   MaxQB; O14317; -.
DR   PaxDb; O14317; -.
DR   PRIDE; O14317; -.
DR   EnsemblFungi; SPAC1071.08.1; SPAC1071.08.1:pep; SPAC1071.08.
DR   GeneID; 2543051; -.
DR   KEGG; spo:SPAC1071.08; -.
DR   PomBase; SPAC1071.08; rpp203.
DR   VEuPathDB; FungiDB:SPAC1071.08; -.
DR   eggNOG; KOG3449; Eukaryota.
DR   HOGENOM; CLU_114656_0_2_1; -.
DR   InParanoid; O14317; -.
DR   OMA; ICKAVHI; -.
DR   PhylomeDB; O14317; -.
DR   Reactome; R-SPO-156827; L13a-mediated translational silencing of Ceruloplasmin expression.
DR   Reactome; R-SPO-1799339; SRP-dependent cotranslational protein targeting to membrane.
DR   Reactome; R-SPO-72689; Formation of a pool of free 40S subunits.
DR   Reactome; R-SPO-72706; GTP hydrolysis and joining of the 60S ribosomal subunit.
DR   Reactome; R-SPO-975956; Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
DR   Reactome; R-SPO-975957; Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).
DR   PRO; PR:O14317; -.
DR   Proteomes; UP000002485; Chromosome I.
DR   GO; GO:0005829; C:cytosol; HDA:PomBase.
DR   GO; GO:0022625; C:cytosolic large ribosomal subunit; ISO:PomBase.
DR   GO; GO:0003735; F:structural constituent of ribosome; ISO:PomBase.
DR   GO; GO:0002182; P:cytoplasmic translational elongation; ISO:PomBase.
DR   CDD; cd05833; Ribosomal_P2; 1.
DR   Gene3D; 1.10.10.1410; -; 1.
DR   HAMAP; MF_01478; Ribosomal_L12_arch; 1.
DR   InterPro; IPR038716; P1/P2_N_sf.
DR   InterPro; IPR027534; Ribosomal_L12/P1/P2.
DR   InterPro; IPR044076; Ribosomal_P2.
DR   InterPro; IPR001859; T.cruzi_P2-like.
DR   PANTHER; PTHR21141; PTHR21141; 1.
DR   PRINTS; PR00456; RIBOSOMALP2.
PE   1: Evidence at protein level;
KW   Cytoplasm; Phosphoprotein; Reference proteome; Ribonucleoprotein;
KW   Ribosomal protein.
FT   CHAIN           1..110
FT                   /note="60S acidic ribosomal protein P2-C"
FT                   /id="PRO_0000339898"
FT   REGION          83..110
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        92..110
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOD_RES         100
FT                   /note="Phosphoserine"
FT                   /evidence="ECO:0000269|PubMed:18257517"
SQ   SEQUENCE   110 AA;  11114 MW;  9481518DDDFB0FBD CRC64;
     MKYLAAYLLL TVGGKNSPSA SDIESVLSTV GIESESERVE ALIKELDGKD IDELIAAGNE
     KLATVPSGGA AAAAAPAAAG GAAPAAEEAA KEEAKEEEES DEDMGFGLFD