RLBP1_MOUSE
ID RLBP1_MOUSE Reviewed; 317 AA.
AC Q9Z275;
DT 11-JAN-2001, integrated into UniProtKB/Swiss-Prot.
DT 23-JAN-2007, sequence version 3.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Retinaldehyde-binding protein 1;
DE AltName: Full=Cellular retinaldehyde-binding protein;
GN Name=Rlbp1 {ECO:0000312|MGI:MGI:97930}; Synonyms=Cralbp;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ;
RX PubMed=9736766;
RA Kennedy B.N., Huang J., Saari J.C., Crabb J.W.;
RT "Molecular characterization of the mouse gene encoding cellular
RT retinaldehyde-binding protein.";
RL Mol. Vis. 4:14-14(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Eye;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=23143414; DOI=10.1038/nchembio.1114;
RA Kaylor J.J., Yuan Q., Cook J., Sarfare S., Makshanoff J., Miu A., Kim A.,
RA Kim P., Habib S., Roybal C.N., Xu T., Nusinowitz S., Travis G.H.;
RT "Identification of DES1 as a vitamin A isomerase in Mueller glial cells of
RT the retina.";
RL Nat. Chem. Biol. 9:30-36(2013).
CC -!- FUNCTION: Soluble retinoid carrier essential the proper function of
CC both rod and cone photoreceptors. Participates in the regeneration of
CC active 11-cis-retinol and 11-cis-retinaldehyde, from the inactive 11-
CC trans products of the rhodopsin photocycle and in the de novo synthesis
CC of these retinoids from 11-trans metabolic precursors. The cycling of
CC retinoids between photoreceptor and adjacent pigment epithelium cells
CC is known as the 'visual cycle'.
CC -!- SUBUNIT: Interacts with DEGS1; the interaction increases synthesis of
CC chromophore-precursors by DEGS1. {ECO:0000250|UniProtKB:E1C1U1}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm.
CC -!- TISSUE SPECIFICITY: Retina and pineal gland. Expressed in Mueller cells
CC (at protein level) (PubMed:23143414). {ECO:0000269|PubMed:23143414}.
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DR EMBL; AF084642; AAC99427.1; -; Genomic_DNA.
DR EMBL; AF084638; AAC99427.1; JOINED; Genomic_DNA.
DR EMBL; AF084639; AAC99427.1; JOINED; Genomic_DNA.
DR EMBL; AF084640; AAC99427.1; JOINED; Genomic_DNA.
DR EMBL; AF084641; AAC99427.1; JOINED; Genomic_DNA.
DR EMBL; BC016268; AAH16268.1; -; mRNA.
DR CCDS; CCDS39990.1; -.
DR RefSeq; NP_001166954.1; NM_001173483.1.
DR RefSeq; NP_065624.1; NM_020599.2.
DR RefSeq; XP_006540780.1; XM_006540717.1.
DR RefSeq; XP_006540781.1; XM_006540718.1.
DR AlphaFoldDB; Q9Z275; -.
DR SMR; Q9Z275; -.
DR BioGRID; 202898; 3.
DR STRING; 10090.ENSMUSP00000054545; -.
DR iPTMnet; Q9Z275; -.
DR PhosphoSitePlus; Q9Z275; -.
DR MaxQB; Q9Z275; -.
DR PaxDb; Q9Z275; -.
DR PRIDE; Q9Z275; -.
DR ProteomicsDB; 299827; -.
DR Antibodypedia; 15709; 272 antibodies from 27 providers.
DR DNASU; 19771; -.
DR Ensembl; ENSMUST00000053718; ENSMUSP00000054545; ENSMUSG00000039194.
DR Ensembl; ENSMUST00000179243; ENSMUSP00000137143; ENSMUSG00000039194.
DR GeneID; 19771; -.
DR KEGG; mmu:19771; -.
DR UCSC; uc009hye.2; mouse.
DR CTD; 6017; -.
DR MGI; MGI:97930; Rlbp1.
DR VEuPathDB; HostDB:ENSMUSG00000039194; -.
DR eggNOG; KOG1471; Eukaryota.
DR GeneTree; ENSGT00940000160026; -.
DR HOGENOM; CLU_046597_4_0_1; -.
DR InParanoid; Q9Z275; -.
DR OMA; GPVFGKC; -.
DR OrthoDB; 1133487at2759; -.
DR PhylomeDB; Q9Z275; -.
DR Reactome; R-MMU-2187335; The retinoid cycle in cones (daylight vision).
DR Reactome; R-MMU-2453902; The canonical retinoid cycle in rods (twilight vision).
DR BioGRID-ORCS; 19771; 0 hits in 75 CRISPR screens.
DR PRO; PR:Q9Z275; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9Z275; protein.
DR Bgee; ENSMUSG00000039194; Expressed in pigmented layer of retina and 138 other tissues.
DR ExpressionAtlas; Q9Z275; baseline and differential.
DR Genevisible; Q9Z275; MM.
DR GO; GO:0044297; C:cell body; ISO:MGI.
DR GO; GO:0005813; C:centrosome; ISO:MGI.
DR GO; GO:0005829; C:cytosol; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005502; F:11-cis retinal binding; IDA:MGI.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IBA:GO_Central.
DR GO; GO:0019841; F:retinol binding; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR GO; GO:0007601; P:visual perception; IEA:UniProtKB-KW.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; -; 1.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011074; CRAL/TRIO_N_dom.
DR InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR InterPro; IPR032941; RLBP1.
DR PANTHER; PTHR10174:SF200; PTHR10174:SF200; 1.
DR Pfam; PF00650; CRAL_TRIO; 1.
DR Pfam; PF03765; CRAL_TRIO_N; 1.
DR SMART; SM01100; CRAL_TRIO_N; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF46938; SSF46938; 1.
DR SUPFAM; SSF52087; SSF52087; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
PE 1: Evidence at protein level;
KW Acetylation; Cytoplasm; Reference proteome; Retinol-binding;
KW Sensory transduction; Transport; Vision.
FT INIT_MET 1
FT /note="Removed"
FT /evidence="ECO:0000250|UniProtKB:P10123"
FT CHAIN 2..317
FT /note="Retinaldehyde-binding protein 1"
FT /id="PRO_0000079331"
FT DOMAIN 136..297
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00056"
FT BINDING 180
FT /ligand="11-cis-retinal"
FT /ligand_id="ChEBI:CHEBI:16066"
FT /evidence="ECO:0000250"
FT BINDING 202
FT /ligand="11-cis-retinal"
FT /ligand_id="ChEBI:CHEBI:16066"
FT /evidence="ECO:0000250"
FT MOD_RES 2
FT /note="N-acetylserine"
FT /evidence="ECO:0000250|UniProtKB:P10123"
SQ SEQUENCE 317 AA; 36408 MW; B337341AAACFAE59 CRC64;
MSDGVGTFRM VPEEEQELRA QLEQLTTKDH GPVFGPCSQL PRHTLQKAKD ELNEKEETRE
EAVRELQELV QAQAASGEEL ALAVAERVQA RDSAFLLRFI RARKFDVGRA YELLKGYVNF
RLQYPELFDS LSMEALRCTI EAGYPGVLSS RDKYGRVVML FNIENWHCEE VTFDEILQAY
CFILEKLLEN EETQINGFCI VENFKGFTMQ QAAGLRPSDL KKMVDMLQDS FPARFKAIHF
IHQPWYFTTT YNVVKPFLKN KLLQRVFVHG DDLDGFFQEI DENILPADFG GTLPKYDGKV
VAEQLFGPRA EVENTAL
