RLCB_LITCL
ID RLCB_LITCL Reviewed; 20 AA.
AC P82877;
DT 16-JAN-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 53.
DE RecName: Full=Ranalexin-1Cb {ECO:0000303|PubMed:10822101};
OS Lithobates clamitans (Green frog) (Rana clamitans).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Neobatrachia; Ranoidea; Ranidae; Lithobates.
OX NCBI_TaxID=145282;
RN [1]
RP PROTEIN SEQUENCE, MASS SPECTROMETRY, AND SUBCELLULAR LOCATION.
RC TISSUE=Skin secretion;
RX PubMed=10822101; DOI=10.1016/s0196-9781(00)00178-9;
RA Halverson T., Basir Y.J., Knoop F.C., Conlon J.M.;
RT "Purification and characterization of antimicrobial peptides from the skin
RT of the North American green frog Rana clamitans.";
RL Peptides 21:469-476(2000).
CC -!- FUNCTION: Antibacterial activity against Gram-positive bacterium
CC S.aureus and Gram-negative bacterium E.coli. Has activity against
CC C.albicans. {ECO:0000250|UniProtKB:P82876}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:10822101}.
CC -!- TISSUE SPECIFICITY: Expressed by the skin glands.
CC {ECO:0000305|PubMed:10822101}.
CC -!- MASS SPECTROMETRY: Mass=2109.0; Mass_error=0.02; Method=Electrospray;
CC Evidence={ECO:0000269|PubMed:10822101};
CC -!- SIMILARITY: Belongs to the frog skin active peptide (FSAP) family.
CC Brevinin subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; P82877; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IEA:UniProtKB-KW.
DR GO; GO:0050832; P:defense response to fungus; IEA:UniProtKB-KW.
DR GO; GO:0031640; P:killing of cells of another organism; IEA:UniProtKB-KW.
DR InterPro; IPR012520; Antimicrobial_frog_1.
DR Pfam; PF08018; Antimicrobial_1; 1.
PE 1: Evidence at protein level;
KW Amphibian defense peptide; Antibiotic; Antimicrobial;
KW Direct protein sequencing; Disulfide bond; Fungicide; Secreted.
FT PEPTIDE 1..20
FT /note="Ranalexin-1Cb"
FT /evidence="ECO:0000269|PubMed:10822101"
FT /id="PRO_0000043557"
FT DISULFID 14..20
FT /evidence="ECO:0000269|PubMed:10822101"
SQ SEQUENCE 20 AA; 2112 MW; 2021802F7BB026D7 CRC64;
FLGGLMKAFP AIICAVTKKC