RLF19_ARATH
ID RLF19_ARATH Reviewed; 110 AA.
AC Q6NME6; Q56ZP5;
DT 28-NOV-2012, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 88.
DE RecName: Full=Protein RALF-like 19;
DE Flags: Precursor;
GN Name=RALFL19; OrderedLocusNames=At2g33775; ORFNames=T1B8;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Cheuk R.F., Chen H., Kim C.J., Shinn P., Carninci P., Hayashizaki Y.,
RA Ishida J., Kamiya A., Kawai J., Narusaka M., Sakurai T., Satou M., Seki M.,
RA Shinozaki K., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (MAR-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=12611624;
RA Olsen A.N., Mundy J., Skriver K.;
RT "Peptomics, identification of novel cationic Arabidopsis peptides with
RT conserved sequence motifs.";
RL In Silico Biol. 2:441-451(2002).
CC -!- FUNCTION: Cell signaling peptide that may regulate plant stress,
CC growth, and development. Mediates a rapid alkalinization of
CC extracellular space by mediating a transient increase in the
CC cytoplasmic Ca(2+) concentration leading to a calcium-dependent
CC signaling events through a cell surface receptor and a concomitant
CC activation of some intracellular mitogen-activated protein kinases (By
CC similarity). {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- PTM: Proteolytically cleaved, probably by S1P, a subtilisin-like serine
CC protease (subtilase). {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the plant rapid alkalinization factor (RALF)
CC family. {ECO:0000305}.
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DR EMBL; U78721; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002685; AEC08883.1; -; Genomic_DNA.
DR EMBL; BT011714; AAS49077.1; -; mRNA.
DR EMBL; AK220918; BAD94374.1; -; mRNA.
DR RefSeq; NP_850219.1; NM_179888.4.
DR AlphaFoldDB; Q6NME6; -.
DR SMR; Q6NME6; -.
DR STRING; 3702.AT2G33775.1; -.
DR PaxDb; Q6NME6; -.
DR PRIDE; Q6NME6; -.
DR ProteomicsDB; 228003; -.
DR EnsemblPlants; AT2G33775.1; AT2G33775.1; AT2G33775.
DR GeneID; 817944; -.
DR Gramene; AT2G33775.1; AT2G33775.1; AT2G33775.
DR KEGG; ath:AT2G33775; -.
DR Araport; AT2G33775; -.
DR TAIR; locus:504955964; AT2G33775.
DR eggNOG; ENOG502S8YN; Eukaryota.
DR HOGENOM; CLU_127895_0_1_1; -.
DR OMA; KSCVNGQ; -.
DR OrthoDB; 1592895at2759; -.
DR PhylomeDB; Q6NME6; -.
DR PRO; PR:Q6NME6; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q6NME6; baseline and differential.
DR GO; GO:0048046; C:apoplast; ISS:TAIR.
DR GO; GO:0090406; C:pollen tube; IDA:TAIR.
DR GO; GO:0005179; F:hormone activity; ISS:UniProtKB.
DR GO; GO:0019722; P:calcium-mediated signaling; ISS:UniProtKB.
DR GO; GO:0007267; P:cell-cell signaling; ISS:TAIR.
DR GO; GO:0080092; P:regulation of pollen tube growth; IGI:TAIR.
DR InterPro; IPR008801; RALF.
DR Pfam; PF05498; RALF; 1.
PE 3: Inferred from homology;
KW Disulfide bond; Hormone; Reference proteome; Secreted; Signal.
FT SIGNAL 1..23
FT /evidence="ECO:0000255"
FT PROPEP 24..58
FT /note="Removed in mature form"
FT /evidence="ECO:0000250"
FT /id="PRO_0000420312"
FT CHAIN 59..110
FT /note="Protein RALF-like 19"
FT /id="PRO_0000420313"
FT SITE 54..55
FT /note="Required for proteolytic cleavage"
FT /evidence="ECO:0000250"
FT DISULFID 76..86
FT /evidence="ECO:0000250"
FT DISULFID 99..105
FT /evidence="ECO:0000250"
FT CONFLICT 80
FT /note="G -> D (in Ref. 4; BAD94374)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 110 AA; 12397 MW; 964FF55E9E94A162 CRC64;
MGIKILLILG LLTLAVVAES ANATWTLTKS CVNGQGCIGE DGELDYLMDS ETNRRQLAAR
RSYISYGALR KNNVPCSRRG RSYYDCKKRK RANPYRRGCS VITHCYRQTS
