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AB12A_ARATH
ID   AB12A_ARATH             Reviewed;         917 AA.
AC   Q9FLT8; F4K3L4;
DT   27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2001, sequence version 1.
DT   03-AUG-2022, entry version 123.
DE   RecName: Full=ABC transporter A family member 12;
DE            Short=ABC transporter ABCA.12;
DE            Short=AtABCA12;
DE   AltName: Full=Putative ABC2 homolog 16;
GN   Name=ABCA12; Synonyms=ATH16; OrderedLocusNames=At5g61700;
GN   ORFNames=K11J9.23, MAC9.1;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA   Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT   features of the regions of 1,456,315 bp covered by nineteen physically
RT   assigned P1 and TAC clones.";
RL   DNA Res. 5:41-54(1998).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA   Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA   Tabata S.;
RT   "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT   features of the regions of 1,367,185 bp covered by 19 physically assigned
RT   P1 and TAC clones.";
RL   DNA Res. 5:203-216(1998).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA   Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT   "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL   J. Biol. Chem. 276:30231-30244(2001).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC       CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
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DR   EMBL; AB010069; BAB10070.1; -; Genomic_DNA.
DR   EMBL; AB012239; BAB10070.1; JOINED; Genomic_DNA.
DR   EMBL; CP002688; AED97507.2; -; Genomic_DNA.
DR   RefSeq; NP_001318859.1; NM_001345489.1.
DR   AlphaFoldDB; Q9FLT8; -.
DR   SMR; Q9FLT8; -.
DR   BioGRID; 21536; 2.
DR   IntAct; Q9FLT8; 2.
DR   STRING; 3702.AT5G61700.1; -.
DR   TCDB; 3.A.1.211.12; the atp-binding cassette (abc) superfamily.
DR   iPTMnet; Q9FLT8; -.
DR   PaxDb; Q9FLT8; -.
DR   PRIDE; Q9FLT8; -.
DR   ProteomicsDB; 245097; -.
DR   EnsemblPlants; AT5G61700.1; AT5G61700.1; AT5G61700.
DR   GeneID; 836292; -.
DR   Gramene; AT5G61700.1; AT5G61700.1; AT5G61700.
DR   KEGG; ath:AT5G61700; -.
DR   Araport; AT5G61700; -.
DR   eggNOG; KOG0059; Eukaryota.
DR   InParanoid; Q9FLT8; -.
DR   OMA; LWRNNSA; -.
DR   OrthoDB; 130188at2759; -.
DR   PhylomeDB; Q9FLT8; -.
DR   BioCyc; ARA:AT5G61700-MON; -.
DR   PRO; PR:Q9FLT8; -.
DR   Proteomes; UP000006548; Chromosome 5.
DR   ExpressionAtlas; Q9FLT8; baseline and differential.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR   GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR   Gene3D; 3.40.50.300; -; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR026082; ABCA.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR19229; PTHR19229; 1.
DR   Pfam; PF00005; ABC_tran; 1.
DR   SMART; SM00382; AAA; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..917
FT                   /note="ABC transporter A family member 12"
FT                   /id="PRO_0000240334"
FT   TRANSMEM        34..54
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        323..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        377..397
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        409..429
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        435..455
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        508..528
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          595..832
FT                   /note="ABC transporter"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         633..640
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   917 AA;  102235 MW;  26D2CEED2561E590 CRC64;
     MVNPSPASFW TQANALLRKN LTYQRKHIWT NVRLILVPLF LCLILLAIQQ VLDALMKGVS
     DMSNCGGNVT LPGGICPIPN PPSLPPMLQI PQHELRSVKT DFFSYKDLPD KLCRETGSCP
     VTILFTGDKL PLGKALSANI FSTSFVVNSS DLLPTLANNV LGSTEAAGED NYEDPGIASD
     LPIYSIQPSC SANSTWPLSL GQIQTAVKCV QGLCLWRNNS VEVNDELFKG SWRGNPAGMP
     NEIVAAYDLM STDRKNFNVT IWYNSTYNDE FATGQALKLV RVPRSINLIS NAYLKFLKGP
     GTRILFEFLK EVPKEETKMN QDIASLLGPL FFTWVVLLLF PVILTSLVYE KQERLRIIMK
     MHGLGDGPYW MISYAYFLTI SMLYVISLVG FGSAIGLKYF RRNDYSIQFV FYFIYSNLQI
     SLAFLVSSIF SKVKTVTVIA YILVYGTGLL GSFLFQKMIE TQSFPEEWIL AMELYPGFSL
     YRGLYEFSQY ASRGNGMKWQ DLSDSGMGEV FCIMSVEWFL ALIVAYYIDQ VFTSGKHPFF
     FLVNLFKSPS SLPRRPTVQR LDSKRVFIDM DKHDVTQERE SVQKLRNEGS TGHAILCDNL
     KKVYPGRDGN PPKMAVRGLY LSVSSGECFG MLGPNGAGKT SFISMMTGLL KPSSGTALVQ
     GLDICKDMNK VYTSMGVCPQ HDLLWETLTG REHLLFYGRL KNIKGSDLTQ AVEESLKSVS
     LYDGGVGDKP AGNYSGGMKR RLSVAISLIG NPKVVYLDEP STGLDPASRK NLWNVIKRAK
     QNTAIILTTH SMEEAEFLCD RLGIFVDGGL QCIGNSKELK SRYGGSYVFT MTTSSKHEEE
     VERLVESVSP NAKKIYHLAG TQKFELPKQE VRIAEVFRAV EKAKANFTVF AWGLADTTLE
     DVFIKVARTA QAFISLS
 
 
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