AB12A_ARATH
ID AB12A_ARATH Reviewed; 917 AA.
AC Q9FLT8; F4K3L4;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=ABC transporter A family member 12;
DE Short=ABC transporter ABCA.12;
DE Short=AtABCA12;
DE AltName: Full=Putative ABC2 homolog 16;
GN Name=ABCA12; Synonyms=ATH16; OrderedLocusNames=At5g61700;
GN ORFNames=K11J9.23, MAC9.1;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9628582; DOI=10.1093/dnares/5.1.41;
RA Sato S., Kaneko T., Kotani H., Nakamura Y., Asamizu E., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. IV. Sequence
RT features of the regions of 1,456,315 bp covered by nineteen physically
RT assigned P1 and TAC clones.";
RL DNA Res. 5:41-54(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9734815; DOI=10.1093/dnares/5.3.203;
RA Kotani H., Nakamura Y., Sato S., Asamizu E., Kaneko T., Miyajima N.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. VI. Sequence
RT features of the regions of 1,367,185 bp covered by 19 physically assigned
RT P1 and TAC clones.";
RL DNA Res. 5:203-216(1998).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCA family.
CC CPR flippase (TC 3.A.1.211) subfamily. {ECO:0000305}.
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DR EMBL; AB010069; BAB10070.1; -; Genomic_DNA.
DR EMBL; AB012239; BAB10070.1; JOINED; Genomic_DNA.
DR EMBL; CP002688; AED97507.2; -; Genomic_DNA.
DR RefSeq; NP_001318859.1; NM_001345489.1.
DR AlphaFoldDB; Q9FLT8; -.
DR SMR; Q9FLT8; -.
DR BioGRID; 21536; 2.
DR IntAct; Q9FLT8; 2.
DR STRING; 3702.AT5G61700.1; -.
DR TCDB; 3.A.1.211.12; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q9FLT8; -.
DR PaxDb; Q9FLT8; -.
DR PRIDE; Q9FLT8; -.
DR ProteomicsDB; 245097; -.
DR EnsemblPlants; AT5G61700.1; AT5G61700.1; AT5G61700.
DR GeneID; 836292; -.
DR Gramene; AT5G61700.1; AT5G61700.1; AT5G61700.
DR KEGG; ath:AT5G61700; -.
DR Araport; AT5G61700; -.
DR eggNOG; KOG0059; Eukaryota.
DR InParanoid; Q9FLT8; -.
DR OMA; LWRNNSA; -.
DR OrthoDB; 130188at2759; -.
DR PhylomeDB; Q9FLT8; -.
DR BioCyc; ARA:AT5G61700-MON; -.
DR PRO; PR:Q9FLT8; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q9FLT8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0043231; C:intracellular membrane-bounded organelle; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0005319; F:lipid transporter activity; IBA:GO_Central.
DR GO; GO:0006869; P:lipid transport; IBA:GO_Central.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR026082; ABCA.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR19229; PTHR19229; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; SSF52540; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 3: Inferred from homology;
KW ATP-binding; Membrane; Nucleotide-binding; Reference proteome;
KW Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..917
FT /note="ABC transporter A family member 12"
FT /id="PRO_0000240334"
FT TRANSMEM 34..54
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 323..343
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 377..397
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 409..429
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 435..455
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 508..528
FT /note="Helical"
FT /evidence="ECO:0000255"
FT DOMAIN 595..832
FT /note="ABC transporter"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 633..640
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ SEQUENCE 917 AA; 102235 MW; 26D2CEED2561E590 CRC64;
MVNPSPASFW TQANALLRKN LTYQRKHIWT NVRLILVPLF LCLILLAIQQ VLDALMKGVS
DMSNCGGNVT LPGGICPIPN PPSLPPMLQI PQHELRSVKT DFFSYKDLPD KLCRETGSCP
VTILFTGDKL PLGKALSANI FSTSFVVNSS DLLPTLANNV LGSTEAAGED NYEDPGIASD
LPIYSIQPSC SANSTWPLSL GQIQTAVKCV QGLCLWRNNS VEVNDELFKG SWRGNPAGMP
NEIVAAYDLM STDRKNFNVT IWYNSTYNDE FATGQALKLV RVPRSINLIS NAYLKFLKGP
GTRILFEFLK EVPKEETKMN QDIASLLGPL FFTWVVLLLF PVILTSLVYE KQERLRIIMK
MHGLGDGPYW MISYAYFLTI SMLYVISLVG FGSAIGLKYF RRNDYSIQFV FYFIYSNLQI
SLAFLVSSIF SKVKTVTVIA YILVYGTGLL GSFLFQKMIE TQSFPEEWIL AMELYPGFSL
YRGLYEFSQY ASRGNGMKWQ DLSDSGMGEV FCIMSVEWFL ALIVAYYIDQ VFTSGKHPFF
FLVNLFKSPS SLPRRPTVQR LDSKRVFIDM DKHDVTQERE SVQKLRNEGS TGHAILCDNL
KKVYPGRDGN PPKMAVRGLY LSVSSGECFG MLGPNGAGKT SFISMMTGLL KPSSGTALVQ
GLDICKDMNK VYTSMGVCPQ HDLLWETLTG REHLLFYGRL KNIKGSDLTQ AVEESLKSVS
LYDGGVGDKP AGNYSGGMKR RLSVAISLIG NPKVVYLDEP STGLDPASRK NLWNVIKRAK
QNTAIILTTH SMEEAEFLCD RLGIFVDGGL QCIGNSKELK SRYGGSYVFT MTTSSKHEEE
VERLVESVSP NAKKIYHLAG TQKFELPKQE VRIAEVFRAV EKAKANFTVF AWGLADTTLE
DVFIKVARTA QAFISLS