AB13B_ARATH
ID AB13B_ARATH Reviewed; 1245 AA.
AC Q9C7F8;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=ABC transporter B family member 13;
DE Short=ABC transporter ABCB.13;
DE Short=AtABCB13;
DE AltName: Full=P-glycoprotein 13;
DE AltName: Full=Putative multidrug resistance protein 15;
GN Name=ABCB13; Synonyms=MDR15, PGP13; OrderedLocusNames=At1g27940;
GN ORFNames=F13K9.5;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
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DR EMBL; AC069471; AAG51482.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30893.1; -; Genomic_DNA.
DR PIR; G86404; G86404.
DR RefSeq; NP_174115.1; NM_102559.2.
DR AlphaFoldDB; Q9C7F8; -.
DR SMR; Q9C7F8; -.
DR BioGRID; 24922; 2.
DR STRING; 3702.AT1G27940.1; -.
DR PaxDb; Q9C7F8; -.
DR PRIDE; Q9C7F8; -.
DR ProteomicsDB; 245143; -.
DR EnsemblPlants; AT1G27940.1; AT1G27940.1; AT1G27940.
DR GeneID; 839687; -.
DR Gramene; AT1G27940.1; AT1G27940.1; AT1G27940.
DR KEGG; ath:AT1G27940; -.
DR Araport; AT1G27940; -.
DR TAIR; locus:2010464; AT1G27940.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; Q9C7F8; -.
DR OMA; WGSKQVR; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; Q9C7F8; -.
DR BioCyc; ARA:AT1G27940-MON; -.
DR PRO; PR:Q9C7F8; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C7F8; baseline and differential.
DR Genevisible; Q9C7F8; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 3.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1245
FT /note="ABC transporter B family member 13"
FT /id="PRO_0000227926"
FT TRANSMEM 48..68
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 94..114
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 171..191
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 195..215
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 276..296
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 314..334
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 686..706
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 725..745
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 805..822
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 828..848
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 913..933
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 947..967
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 47..336
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 372..607
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 681..969
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1004..1240
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT REGION 1..20
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 610..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 644..660
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 406..413
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1039..1046
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 77
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 391
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 778
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1008
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1106
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1245 AA; 135776 MW; FDCE513FC3F14A1C CRC64;
MDNTERSSNG NIQAETEAKE EKKNIKKESV SLMGLFSAAD KLDYFLMLLG GLGACIHGAT
LPLFFVFFGK MLDSLGNLST DPKAISSRVS QNALYLVYLG LVNFVSAWIG VSCWMQTGER
QTARLRINYL KSILAKDITF FDTEARDSNL IFHISSDAIL VQDAIGDKTD HVLRYLSQFI
AGFVIGFLSV WQLTLLTLGV VPLIAIAGGG YAIVMSTISE KSETAYADAG KVAEEVMSQV
RTVYAFVGEE KAVKSYSNSL KKALKLGKRS GLAKGLGVGL TYSLLFCAWA LLLWYASLLV
RHGKTNGAKA FTTILNVIFS GFALGQAAPS LSAIAKGRVA AANIFRMIGN NNSESSQRLD
EGTTLQNVAG RIEFQKVSFA YPSRPNMVFE NLSFTIRSGK TFAFVGPSGS GKSTIISMVQ
RFYEPNSGEI LLDGNDIKSL KLKWFREQLG LVSQEPALFA TTIASNILLG KENANMDQII
EAAKAANADS FIKSLPNGYN TQVGEGGTQL SGGQKQRIAI ARAVLRNPKI LLLDEATSAL
DAESEKIVQQ ALDNVMEKRT TIVVAHRLST IRNVDKIVVL RDGQVRETGS HSELMLRGGD
YATLVNCQET EPQENSRSIM SETCKSQAGS SSSRRVSSSR RTSSFRVDQE KTKNDDSKKD
FSSSSMIWEL IKLNSPEWPY ALLGSIGAVL AGAQTPLFSM GIAYVLTAFY SPFPNVIKRD
VEKVAIIFAG AGIVTAPIYL LQHYFYTLMG ERLTSRVRLS LFSAILSNEI GWFDLDENNT
GSLTSILAAD ATLVRSALAD RLSTIVQNLS LTVTALALAF FYSWRVAAVV TACFPLLIAA
SLTEQLFLKG FGGDYTRAYS RATSVAREAI ANIRTVAAYG AEKQISEQFT CELSKPTKNA
FVRGHISGFG YGLSQFLAFC SYALGLWYVS VLINHKETNF GDSIKSFMVL IVTAFSVSET
LALTPDIVKG TQALGSVFRV LHRETKISPD QPNSRMVSQV KGDIEFRNVS FVYPTRPEID
IFKNLNLRVS AGKSLAVVGP SGSGKSTVIG LIMRFYDPSN GNLCIDGQDI KTLNLRSLRK
KLALVQQEPA LFSTTIYENI KYGNENASEA EIMEAAKAAN AHEFIIKMEE GYKTHAGDKG
VQLSGGQKQR VAIARAVLKD PSVLLLDEAT SALDTSSEKL VQEALDKLMK GRTTVLVAHR
LSTIRKADTV AVLHKGRVVE KGSHRELVSI PNGFYKQLTS LQEVL
