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RLMG_AERS4
ID   RLMG_AERS4              Reviewed;         377 AA.
AC   A4SQM2;
DT   24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT   24-MAR-2009, sequence version 2.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Ribosomal RNA large subunit methyltransferase G {ECO:0000255|HAMAP-Rule:MF_01859};
DE            EC=2.1.1.174 {ECO:0000255|HAMAP-Rule:MF_01859};
DE   AltName: Full=23S rRNA m2G1835 methyltransferase {ECO:0000255|HAMAP-Rule:MF_01859};
DE   AltName: Full=rRNA (guanine-N(2)-)-methyltransferase RlmG {ECO:0000255|HAMAP-Rule:MF_01859};
GN   Name=rlmG {ECO:0000255|HAMAP-Rule:MF_01859}; OrderedLocusNames=ASA_3201;
OS   Aeromonas salmonicida (strain A449).
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Aeromonadales;
OC   Aeromonadaceae; Aeromonas.
OX   NCBI_TaxID=382245;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=A449;
RX   PubMed=18801193; DOI=10.1186/1471-2164-9-427;
RA   Reith M.E., Singh R.K., Curtis B., Boyd J.M., Bouevitch A., Kimball J.,
RA   Munholland J., Murphy C., Sarty D., Williams J., Nash J.H., Johnson S.C.,
RA   Brown L.L.;
RT   "The genome of Aeromonas salmonicida subsp. salmonicida A449: insights into
RT   the evolution of a fish pathogen.";
RL   BMC Genomics 9:427-427(2008).
CC   -!- FUNCTION: Specifically methylates the guanine in position 1835
CC       (m2G1835) of 23S rRNA. {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=guanosine(1835) in 23S rRNA + S-adenosyl-L-methionine = H(+) +
CC         N(2)-methylguanosine(1835) in 23S rRNA + S-adenosyl-L-homocysteine;
CC         Xref=Rhea:RHEA:42744, Rhea:RHEA-COMP:10217, Rhea:RHEA-COMP:10218,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC         ChEBI:CHEBI:74269, ChEBI:CHEBI:74481; EC=2.1.1.174;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_01859};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- SIMILARITY: Belongs to the methyltransferase superfamily. RlmG family.
CC       {ECO:0000255|HAMAP-Rule:MF_01859}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=ABO91194.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CP000644; ABO91194.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; WP_042467131.1; NC_009348.1.
DR   AlphaFoldDB; A4SQM2; -.
DR   SMR; A4SQM2; -.
DR   STRING; 382245.ASA_3201; -.
DR   EnsemblBacteria; ABO91194; ABO91194; ASA_3201.
DR   KEGG; asa:ASA_3201; -.
DR   eggNOG; COG2813; Bacteria.
DR   HOGENOM; CLU_040288_4_0_6; -.
DR   OrthoDB; 1027015at2; -.
DR   Proteomes; UP000000225; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0052916; F:23S rRNA (guanine(1835)-N(2))-methyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   Gene3D; 3.40.50.150; -; 2.
DR   HAMAP; MF_01859; 23SrRNA_methyltr_G; 1.
DR   InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR   InterPro; IPR017237; rRNA_m2G-MeTrfase_RsmD.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR007848; Small_mtfrase_dom.
DR   PANTHER; PTHR47816:SF5; PTHR47816:SF5; 1.
DR   Pfam; PF05175; MTS; 1.
DR   PIRSF; PIRSF037565; RRNA_m2G_Mtase_RsmD_prd; 1.
DR   SUPFAM; SSF53335; SSF53335; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Methyltransferase; rRNA processing; S-adenosyl-L-methionine;
KW   Transferase.
FT   CHAIN           1..377
FT                   /note="Ribosomal RNA large subunit methyltransferase G"
FT                   /id="PRO_0000366445"
SQ   SEQUENCE   377 AA;  41548 MW;  50F023C7CEFB6565 CRC64;
     MQTLLDTAHC RLTLYRYPRQ SQDPLQAWDA ADEYLINTLA ETPLEQAGPV IIMNDGFGAL
     AAFLHPHAPV CVSDSYISER ATLANLAENE LDPHAIRLQD ALAPLPLAPA LVVIKVSKYQ
     ALLEQQLLAL RAVVTPATRV IAAGKAKDIH SSTLALFEKY LGPTRTSLAW KKARLIHCEP
     QAMQPELANP YPTVWPLEGT GMLIHNHANV FSRTSLDIGA RFMLDNLPVH SARKVIDLGC
     GNGVLGLALL AKDPEVEVTF IDESHMAVAS ARLNVEHNLP DALPRARFMV NNCLDDVAVG
     AADRILCNPP FHQLQAITDH IAWQMFSDAH RVLPQGGELW IVGNRHLDYH NKLKRLFANA
     QVVASNSKFV ILKAIKR
 
 
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