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AB13C_ORYSJ
ID   AB13C_ORYSJ             Reviewed;        1505 AA.
AC   Q10RX7; A0A0P0VSW0;
DT   04-FEB-2015, integrated into UniProtKB/Swiss-Prot.
DT   22-AUG-2006, sequence version 1.
DT   03-AUG-2022, entry version 127.
DE   RecName: Full=ABC transporter C family member 13 {ECO:0000303|PubMed:18299247};
DE            Short=OsABCC13 {ECO:0000303|PubMed:18299247};
DE            EC=7.-.-.- {ECO:0000305};
DE   AltName: Full=Multidrug resistance-associated protein 13 {ECO:0000303|PubMed:16375897};
DE            Short=OsMRP13 {ECO:0000303|PubMed:16375897};
DE   AltName: Full=OsMRP5 {ECO:0000303|PubMed:19370321};
DE   AltName: Full=Protein LOW PHYTIC ACID 2 {ECO:0000303|PubMed:19370321};
GN   Name=ABCC13 {ECO:0000303|PubMed:18299247};
GN   Synonyms=LPA2 {ECO:0000303|PubMed:19370321};
GN   OrderedLocusNames=Os03g0142800 {ECO:0000312|EMBL:BAF10848.1},
GN   LOC_Os03g04920 {ECO:0000312|EMBL:ABF93919.1};
OS   Oryza sativa subsp. japonica (Rice).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Oryzoideae; Oryzeae; Oryzinae; Oryza; Oryza sativa.
OX   NCBI_TaxID=39947;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16109971; DOI=10.1101/gr.3869505;
RG   The rice chromosome 3 sequencing consortium;
RA   Buell C.R., Yuan Q., Ouyang S., Liu J., Zhu W., Wang A., Maiti R., Haas B.,
RA   Wortman J., Pertea M., Jones K.M., Kim M., Overton L., Tsitrin T.,
RA   Fadrosh D., Bera J., Weaver B., Jin S., Johri S., Reardon M., Webb K.,
RA   Hill J., Moffat K., Tallon L., Van Aken S., Lewis M., Utterback T.,
RA   Feldblyum T., Zismann V., Iobst S., Hsiao J., de Vazeille A.R.,
RA   Salzberg S.L., White O., Fraser C.M., Yu Y., Kim H., Rambo T., Currie J.,
RA   Collura K., Kernodle-Thompson S., Wei F., Kudrna K., Ammiraju J.S.S.,
RA   Luo M., Goicoechea J.L., Wing R.A., Henry D., Oates R., Palmer M.,
RA   Pries G., Saski C., Simmons J., Soderlund C., Nelson W., de la Bastide M.,
RA   Spiegel L., Nascimento L., Huang E., Preston R., Zutavern T., Palmer L.,
RA   O'Shaughnessy A., Dike S., McCombie W.R., Minx P., Cordum H., Wilson R.,
RA   Jin W., Lee H.R., Jiang J., Jackson S.;
RT   "Sequence, annotation, and analysis of synteny between rice chromosome 3
RT   and diverged grass species.";
RL   Genome Res. 15:1284-1291(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Nipponbare;
RX   PubMed=16100779; DOI=10.1038/nature03895;
RG   International rice genome sequencing project (IRGSP);
RT   "The map-based sequence of the rice genome.";
RL   Nature 436:793-800(2005).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=18089549; DOI=10.1093/nar/gkm978;
RG   The rice annotation project (RAP);
RT   "The rice annotation project database (RAP-DB): 2008 update.";
RL   Nucleic Acids Res. 36:D1028-D1033(2008).
RN   [4]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Nipponbare;
RX   PubMed=24280374; DOI=10.1186/1939-8433-6-4;
RA   Kawahara Y., de la Bastide M., Hamilton J.P., Kanamori H., McCombie W.R.,
RA   Ouyang S., Schwartz D.C., Tanaka T., Wu J., Zhou S., Childs K.L.,
RA   Davidson R.M., Lin H., Quesada-Ocampo L., Vaillancourt B., Sakai H.,
RA   Lee S.S., Kim J., Numa H., Itoh T., Buell C.R., Matsumoto T.;
RT   "Improvement of the Oryza sativa Nipponbare reference genome using next
RT   generation sequence and optical map data.";
RL   Rice 6:4-4(2013).
RN   [5]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=16375897; DOI=10.1016/j.febslet.2005.11.056;
RA   Klein M., Burla B., Martinoia E.;
RT   "The multidrug resistance-associated protein (MRP/ABCC) subfamily of ATP-
RT   binding cassette transporters in plants.";
RL   FEBS Lett. 580:1112-1122(2006).
RN   [6]
RP   GENE FAMILY, AND NOMENCLATURE.
RX   PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA   Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA   Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA   Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT   "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL   Trends Plant Sci. 13:151-159(2008).
RN   [7]
RP   FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX   PubMed=19370321; DOI=10.1007/s00122-009-1018-1;
RA   Xu X.H., Zhao H.J., Liu Q.L., Frank T., Engel K.H., An G., Shu Q.Y.;
RT   "Mutations of the multi-drug resistance-associated protein ABC transporter
RT   gene 5 result in reduction of phytic acid in rice seeds.";
RL   Theor. Appl. Genet. 119:75-83(2009).
CC   -!- FUNCTION: ABC transporter that may affect phytic acid transport and
CC       compartmentalization. May function directly or indirectly in removing
CC       phytic acid from the cytosol or in vesicle trafficking. Required for
CC       phytic acid accumulation in developing seeds. Phytic acid is the
CC       primary storage form of phosphorus in cereal grains and other plant
CC       seeds. {ECO:0000269|PubMed:19370321}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- TISSUE SPECIFICITY: Expressed in roots, leaf sheaths, leaf blades and
CC       developing seeds. {ECO:0000269|PubMed:19370321}.
CC   -!- DISRUPTION PHENOTYPE: Strong reduction in seed phytic acid, and strong
CC       increase of inorganic phosphate and myo-inositol levels in seeds.
CC       Seedling lethality when homozygous. {ECO:0000269|PubMed:19370321}.
CC   -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCC family.
CC       Conjugate transporter (TC 3.A.1.208) subfamily. {ECO:0000305}.
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DR   EMBL; DP000009; ABF93919.1; -; Genomic_DNA.
DR   EMBL; AP008209; BAF10848.1; -; Genomic_DNA.
DR   EMBL; AP014959; BAS82235.1; -; Genomic_DNA.
DR   RefSeq; XP_015630971.1; XM_015775485.1.
DR   AlphaFoldDB; Q10RX7; -.
DR   SMR; Q10RX7; -.
DR   STRING; 4530.OS03T0142800-01; -.
DR   TCDB; 3.A.1.208.34; the atp-binding cassette (abc) superfamily.
DR   PaxDb; Q10RX7; -.
DR   PRIDE; Q10RX7; -.
DR   EnsemblPlants; Os03t0142800-01; Os03t0142800-01; Os03g0142800.
DR   GeneID; 4331585; -.
DR   Gramene; Os03t0142800-01; Os03t0142800-01; Os03g0142800.
DR   KEGG; osa:4331585; -.
DR   eggNOG; KOG0054; Eukaryota.
DR   HOGENOM; CLU_000604_27_3_1; -.
DR   InParanoid; Q10RX7; -.
DR   OMA; FVKFFGW; -.
DR   OrthoDB; 138195at2759; -.
DR   Proteomes; UP000000763; Chromosome 3.
DR   Proteomes; UP000059680; Chromosome 3.
DR   ExpressionAtlas; Q10RX7; baseline and differential.
DR   Genevisible; Q10RX7; OS.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0016020; C:membrane; IBA:GO_Central.
DR   GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR   GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR   GO; GO:0055085; P:transmembrane transport; IMP:UniProtKB.
DR   CDD; cd18579; ABC_6TM_ABCC_D1; 1.
DR   CDD; cd18580; ABC_6TM_ABCC_D2; 1.
DR   Gene3D; 1.20.1560.10; -; 2.
DR   Gene3D; 3.40.50.300; -; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR011527; ABC1_TM_dom.
DR   InterPro; IPR036640; ABC1_TM_sf.
DR   InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR   InterPro; IPR017871; ABC_transporter-like_CS.
DR   InterPro; IPR044746; ABCC_6TM_D1.
DR   InterPro; IPR044726; ABCC_6TM_D2.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   Pfam; PF00664; ABC_membrane; 2.
DR   Pfam; PF00005; ABC_tran; 2.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; SSF52540; 2.
DR   SUPFAM; SSF90123; SSF90123; 2.
DR   PROSITE; PS50929; ABC_TM1F; 2.
DR   PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR   PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE   2: Evidence at transcript level;
KW   ATP-binding; Membrane; Nucleotide-binding; Reference proteome; Repeat;
KW   Translocase; Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..1505
FT                   /note="ABC transporter C family member 13"
FT                   /id="PRO_0000431886"
FT   TRANSMEM        11..31
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        54..68
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        71..91
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        102..122
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        171..191
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        313..333
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        336..356
FT                   /note="Helical; Name=8"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        367..387
FT                   /note="Helical; Name=9"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        421..441
FT                   /note="Helical; Name=10"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        447..467
FT                   /note="Helical; Name=11"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        534..554
FT                   /note="Helical; Name=12"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        940..960
FT                   /note="Helical; Name=13"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        980..1000
FT                   /note="Helical; Name=14"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1055..1077
FT                   /note="Helical; Name=15"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1081..1103
FT                   /note="Helical; Name=16"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1149..1169
FT                   /note="Helical; Name=17"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        1174..1194
FT                   /note="Helical; Name=18"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          314..589
FT                   /note="ABC transmembrane type-1 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          623..846
FT                   /note="ABC transporter 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   DOMAIN          945..1215
FT                   /note="ABC transmembrane type-1 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT   DOMAIN          1262..1496
FT                   /note="ABC transporter 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   REGION          881..919
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   BINDING         658..665
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT   BINDING         1296..1303
FT                   /ligand="ATP"
FT                   /ligand_id="ChEBI:CHEBI:30616"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
SQ   SEQUENCE   1505 AA;  166149 MW;  037D36E9F71112DB CRC64;
     MPHFPNLPLP EAAAAAAHAA LLALALLLLL LRSARALASR CASCLKTAPR RAAAVDGGLA
     AASSVGAWYR AALACCGYAL LAQVAALSYE VAVAGSHVAV EALLLPAVQA LAWAALLALA
     MQARAVGWGR FPVLVRVWWV VSFVLCVGIA YDDTRHLMGD DDDDEVDYAH MVANFASAPA
     LGFLCLVGVM GSTGVELEFT DDDSSVHEPL LLGGQRRDAD EEPGCLRVTP YGDAGIVSLA
     TLSWLSPLLS VGAQRPLELA DIPLMAHKDR AKSCYKAMSS HYERQRMERP GSEPSLAWAI
     LKSFWREAAI NGAFAAVNTI VSYVGPYLIS YFVDYLSGKI EFPHEGYILA SVFFVAKLLE
     TLTARQWYLG VDVMGIHVKS GLTAMVYRKG LRLSNSSRQS HTSGEIVNYM AVDVQRVGDY
     AWYFHDIWML PLQIILALAI LYKNVGIAMV STLVATVLSI AASVPVAKLQ EHYQDKLMAS
     KDERMRKTSE CLKNMRILKL QAWEDRYRLK LEEMRNVECK WLRWALYSQA AVTFVFWSSP
     IFVAVITFGT CILLGGELTA GGVLSALATF RILQEPLRNF PDLISMIAQT RVSLDRLSHF
     LQQEELPDDA TITVPHGSTD KAININDATF SWNPSSPTPT LSGINLSVVR GMRVAVCGVI
     GSGKSSLLSS ILGEIPKLCG QVRISGSAAY VPQTAWIQSG NIEENILFGS PMDKQRYKRV
     IEACSLKKDL QLLQYGDQTI IGDRGINLSG GQKQRVQLAR ALYQDADIYL LDDPFSAVDA
     HTGSELFREY ILTALASKTV IYVTHQIEFL PAADLILVLK DGHITQAGKY DDLLQAGTDF
     NALVCAHKEA IETMEFSEDS DEDTVSSVPI KRLTPSVSNI DNLKNKVSNN EKPSSTRGIK
     EKKKKPEERK KKRSVQEEER ERGRVSLQVY LSYMGEAYKG TLIPLIILAQ TMFQVLQIAS
     NWWMAWANPQ TEGDAPKTDS VVLLVVYMSL AFGSSLFVFV RSLLVATFGL ATAQKLFVKM
     LRCVFRAPMS FFDTTPSGRI LNRVSVDQSV VDLDIAFRLG GFASTTIQLL GIVAVMSKVT
     WQVLILIVPM AVACMWMQRY YIASSRELTR ILSVQKSPVI HLFSESIAGA ATIRGFGQEK
     RFMKRNLYLL DCFARPLFSS LAAIEWLCLR MELLSTFVFA FCMAILVSFP PGTIEPSMAG
     LAVTYGLNLN ARMSRWILSF CKLENRIISV ERIYQYCKLP SEAPLIIENS RPSSSWPENG
     NIELVDLKVR YKDDLPLVLH GISCIFPGGK KIGIVGRTGS GKSTLIQALF RLIEPTGGKV
     IIDDVDISRI GLHDLRSRLS IIPQDPTLFE GTIRMNLDPL EECTDQEIWE ALEKCQLGEV
     IRSKDEKLDS PVLENGDNWS VGQRQLIALG RALLKQAKIL VLDEATASVD TATDNLIQKI
     IRSEFKDCTV CTIAHRIPTV IDSDLVLVLS DGKIAEFDTP QRLLEDKSSM FMQLVSEYST
     RSSCI
 
 
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