AB14B_ARATH
ID AB14B_ARATH Reviewed; 1247 AA.
AC Q9C7F2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=ABC transporter B family member 14;
DE Short=ABC transporter ABCB.14;
DE Short=AtABCB14;
DE AltName: Full=Multidrug resistance protein 12;
DE AltName: Full=P-glycoprotein 14;
GN Name=ABCB14; Synonyms=MDR12, PGP14; OrderedLocusNames=At1g28010;
GN ORFNames=F13K9.11;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
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DR EMBL; AC069471; AAG51476.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE30902.1; -; Genomic_DNA.
DR PIR; F86405; F86405.
DR RefSeq; NP_174122.1; NM_102566.3.
DR AlphaFoldDB; Q9C7F2; -.
DR SMR; Q9C7F2; -.
DR STRING; 3702.AT1G28010.1; -.
DR TCDB; 3.A.1.201.33; the atp-binding cassette (abc) superfamily.
DR iPTMnet; Q9C7F2; -.
DR PaxDb; Q9C7F2; -.
DR PRIDE; Q9C7F2; -.
DR ProteomicsDB; 244528; -.
DR EnsemblPlants; AT1G28010.1; AT1G28010.1; AT1G28010.
DR GeneID; 839694; -.
DR Gramene; AT1G28010.1; AT1G28010.1; AT1G28010.
DR KEGG; ath:AT1G28010; -.
DR Araport; AT1G28010; -.
DR TAIR; locus:2010444; AT1G28010.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; Q9C7F2; -.
DR OMA; DAYFTRY; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; Q9C7F2; -.
DR BioCyc; ARA:AT1G28010-MON; -.
DR PRO; PR:Q9C7F2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C7F2; baseline and differential.
DR Genevisible; Q9C7F2; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 3: Inferred from homology;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1247
FT /note="ABC transporter B family member 14"
FT /id="PRO_0000227923"
FT TRANSMEM 49..69
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 95..115
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 172..192
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 196..216
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 277..297
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 315..335
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 680..700
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 727..747
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 807..824
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 830..850
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 915..935
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 949..969
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 48..337
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 373..608
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 679..971
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 1006..1242
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 407..414
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1041..1048
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 392
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 780
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 938
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1010
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1108
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1247 AA; 136176 MW; C036DBD9C770DF1B CRC64;
MDNIEPPFSG NIHAETEVKK EEKKKMKKES VSLMGLFSAA DNVDYFLMFL GGLGTCIHGG
TLPLFFVFFG GMLDSLGKLS TDPNAISSRV SQNALYLVYL GLVNLVSAWI GVACWMQTGE
RQTARLRINY LKSILAKDIT FFDTEARDSN FIFHISSDAI LVQDAIGDKT GHVLRYLCQF
IAGFVIGFLS VWQLTLLTLG VVPLIAIAGG GYAIVMSTIS EKSEAAYADA GKVAEEVMSQ
VRTVYAFVGE EKAVKSYSNS LKKALKLSKR SGLAKGLGVG LTYSLLFCAW ALLFWYASLL
VRHGKTNGAK AFTTILNVIY SGFALGQAVP SLSAISKGRV AAANIFKMIG NNNLESSERL
ENGTTLQNVV GKIEFCGVSF AYPSRPNMVF ENLSFTIHSG KTFAFVGPSG SGKSTIISMV
QRFYEPRSGE ILLDGNDIKN LKLKWLREQM GLVSQEPALF ATTIASNILL GKEKANMDQI
IEAAKAANAD SFIKSLPNGY NTQVGEGGTQ LSGGQKQRIA IARAVLRNPK ILLLDEATSA
LDAESEKIVQ QALDNVMEKR TTIVIAHRLS TIRNVDKIVV LRDGQVRETG SHSELISRGG
DYATLVNCQD TEPQENLRSV MYESCRSQAG SYSSRRVFSS RRTSSFREDQ EKTEKDSKGE
DLISSSSMIW ELIKLNAPEW LYALLGSIGA VLAGSQPALF SMGLAYVLTT FYSPFPSLIK
REVDKVAIIF VGAGIVTAPI YILQHYFYTL MGERLTSRVR LSLFSAILSN EIGWFDLDEN
NTGSLTSILA ADATLVRSAI ADRLSTIVQN LSLTITALAL AFFYSWRVAA VVTACFPLLI
AASLTEQLFL KGFGGDYTRA YSRATSLARE AISNIRTVAA FSAEKQISEQ FTCELSKPTK
SALLRGHISG FGYGLSQCLA FCSYALGLWY ISVLIKRNET NFEDSIKSFM VLLVTAYSVA
ETLALTPDIV KGTQALGSVF RVLHRETEIP PDQPNSRLVT HIKGDIEFRN VSFAYPTRPE
IAIFKNLNLR VSAGKSLAVV GPSGSGKSTV IGLIMRFYDP SNGNLCIDGH DIKSVNLRSL
RKKLALVQQE PALFSTSIHE NIKYGNENAS EAEIIEAAKA ANAHEFISRM EEGYMTHVGD
KGVQLSGGQK QRVAIARAVL KDPSVLLLDE ATSALDTSAE KQVQEALDKL MKGRTTILVA
HRLSTIRKAD TIVVLHKGKV VEKGSHRELV SKSDGFYKKL TSLQEAV
