AB16B_ARATH
ID AB16B_ARATH Reviewed; 1228 AA.
AC Q9LSJ8; Q8RXD2;
DT 21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 139.
DE RecName: Full=ABC transporter B family member 16;
DE Short=ABC transporter ABCB.16;
DE Short=AtABCB16;
DE AltName: Full=Multidrug resistance protein 18;
DE AltName: Full=P-glycoprotein 16;
GN Name=ABCB16; Synonyms=MDR18, PGP16; OrderedLocusNames=At3g28360;
GN ORFNames=MFJ20.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 612-1228.
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11346655; DOI=10.1074/jbc.m103104200;
RA Sanchez-Fernandez R., Davies T.G., Coleman J.O., Rea P.A.;
RT "The Arabidopsis thaliana ABC protein superfamily, a complete inventory.";
RL J. Biol. Chem. 276:30231-30244(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18299247; DOI=10.1016/j.tplants.2008.02.001;
RA Verrier P.J., Bird D., Burla B., Dassa E., Forestier C., Geisler M.,
RA Klein M., Kolukisaoglu H.U., Lee Y., Martinoia E., Murphy A., Rea P.A.,
RA Samuels L., Schulz B., Spalding E.J., Yazaki K., Theodoulou F.L.;
RT "Plant ABC proteins - a unified nomenclature and updated inventory.";
RL Trends Plant Sci. 13:151-159(2008).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000255|PROSITE-ProRule:PRU00441};
CC Multi-pass membrane protein {ECO:0000255|PROSITE-ProRule:PRU00441}.
CC -!- SIMILARITY: Belongs to the ABC transporter superfamily. ABCB family.
CC Multidrug resistance exporter (TC 3.A.1.201) subfamily. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL91219.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB026644; BAB02852.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE77437.1; -; Genomic_DNA.
DR EMBL; AY081330; AAL91219.1; ALT_INIT; mRNA.
DR EMBL; BT008368; AAP37727.1; -; mRNA.
DR RefSeq; NP_189477.4; NM_113756.5.
DR AlphaFoldDB; Q9LSJ8; -.
DR SMR; Q9LSJ8; -.
DR BioGRID; 7794; 7.
DR IntAct; Q9LSJ8; 6.
DR STRING; 3702.AT3G28360.1; -.
DR PaxDb; Q9LSJ8; -.
DR PRIDE; Q9LSJ8; -.
DR ProteomicsDB; 245120; -.
DR EnsemblPlants; AT3G28360.1; AT3G28360.1; AT3G28360.
DR GeneID; 822465; -.
DR Gramene; AT3G28360.1; AT3G28360.1; AT3G28360.
DR KEGG; ath:AT3G28360; -.
DR Araport; AT3G28360; -.
DR TAIR; locus:2088912; AT3G28360.
DR eggNOG; KOG0055; Eukaryota.
DR HOGENOM; CLU_000604_17_2_1; -.
DR InParanoid; Q9LSJ8; -.
DR OMA; QRIAYHE; -.
DR OrthoDB; 186078at2759; -.
DR PhylomeDB; Q9LSJ8; -.
DR BioCyc; ARA:AT3G28360-MON; -.
DR PRO; PR:Q9LSJ8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LSJ8; baseline and differential.
DR Genevisible; Q9LSJ8; AT.
DR GO; GO:0016021; C:integral component of membrane; IBA:GO_Central.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0042626; F:ATPase-coupled transmembrane transporter activity; IBA:GO_Central.
DR GO; GO:0055085; P:transmembrane transport; IBA:GO_Central.
DR Gene3D; 1.20.1560.10; -; 1.
DR Gene3D; 3.40.50.300; -; 2.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR011527; ABC1_TM_dom.
DR InterPro; IPR036640; ABC1_TM_sf.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR039421; Type_1_exporter.
DR PANTHER; PTHR24221; PTHR24221; 1.
DR Pfam; PF00664; ABC_membrane; 2.
DR Pfam; PF00005; ABC_tran; 2.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; SSF52540; 2.
DR SUPFAM; SSF90123; SSF90123; 2.
DR PROSITE; PS50929; ABC_TM1F; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 2.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 2.
PE 2: Evidence at transcript level;
KW ATP-binding; Glycoprotein; Membrane; Nucleotide-binding;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..1228
FT /note="ABC transporter B family member 16"
FT /id="PRO_0000227929"
FT TRANSMEM 22..42
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 69..89
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 145..167
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 171..193
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 251..271
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 283..303
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 667..687
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 700..720
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 781..801
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 805..825
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 881..901
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT TRANSMEM 920..940
FT /note="Helical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 22..311
FT /note="ABC transmembrane type-1 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 346..582
FT /note="ABC transporter 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT DOMAIN 658..946
FT /note="ABC transmembrane type-1 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
FT DOMAIN 981..1219
FT /note="ABC transporter 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 381..388
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT BINDING 1016..1023
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /ligand_label="2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00434"
FT CARBOHYD 529
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 593
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 628
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 755
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 827
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 1001
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 1228 AA; 135916 MW; B1FE531C4DF920CB CRC64;
MKTWGSMRSI FMHADGVDWM LMGLGLIGAV GDGFITPILF FITAMLLNDF GSFSFNDETF
MQPISKNALA MLYVACASWV ICFLEGYCWT RTGERQAAKM RERYLRAVLR QDVGYFDLHV
TSTSDIITSV SSDSLVIQDF LSEKLPNILM NASAFVGSYI VGFMLLWRLT IVGFPFIILL
LIPGLMYGRA LIGISRKIRE EYNEAGSIAE QAISSVRTVY AFVSEKKMIE KFSDALQGSV
KLGLRQGLAK GIAIGSNGIV YAIWGFLTWY GSRMVMNYGY KGGTVSTVTV CVTFGGTALG
QALSNLKYFS EAFVAGERIQ KMIKRVPDID SDNLNGHILE TIRGEVEFNN VKCKYPSRPE
TLIFDDLCLK IPSGKTVALV GGSGSGKSTV ISLLQRFYDP NEGDILIDSV SINNMQVKWL
RSQMGMVSQE PSLFATSIKE NILFGKEDAS FDEVVEAAKA SNAHNFISQF PHGYQTQVGE
RGVHMSGGQK QRIAIARALI KSPIILLLDE ATSALDLESE RVVQEALDNA SVGRTTIVIA
HRLSTIRNAD IICVLHNGCI VETGSHDKLM EIDGKYTSLV RLQQMKNEES CDNTSVGVKE
GRVSSLRNDL DYNPRDLAHS MSSSIVTNLS DSIPQDKKPL VPSFKRLMAM NRPEWKHALC
GCLSASLGGA VQPIYAYSSG LMISVFFLTN HEQIKENTRI YVLLFFGLAL FTFFTSISQQ
YSFSYMGEYL TKRIREQMLS KILTFEVNWF DEEENSSGAI CSRLAKDANV VRSLVGERMS
LLVQTISTVM VACTIGLVIA WRFTIVMISV QPVIIVCYYI QRVLLKNMSK KAIIAQDESS
KLAAEAVSNI RTITTFSSQE RIMKLLERVQ EGPRRESARQ SWLAGIMLGT TQSLITCTSA
LNFWYGGKLI ADGKMVSKAF FELFLIFKTT GRAIAEAGTM TTDLAKGSNS VDSVFTVLDR
RTTIEPENPD GYILEKIKGQ ITFLNVDFAY PTRPNMVIFN NFSIEIHEGK STAIVGPSRS
GKSTVIGLIE RFYDPLQGIV KIDGRDIRSY HLRSLRQHMS LVSQEPTLFA GTIRENIMYG
RASNKIDESE IIEAGKTANA HEFITSLSDG YDTYCGDRGV QLSGGQKQRI AIARTILKNP
SILLLDEATS ALDSQSERVV QDALEHVMVG KTSVVIAHRL STIQNCDTIA VLDKGKVVES
GTHASLLAKG PTGSYFSLVS LQRKVRYV
