RLP12_ARATH
ID RLP12_ARATH Reviewed; 847 AA.
AC Q9C9H7;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 31-MAY-2011, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Receptor-like protein 12 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP12 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP12 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At1g71400 {ECO:0000312|Araport:AT1G71400};
GN ORFNames=F26A9.22 {ECO:0000312|EMBL:AAG51836.1},
GN F3I17.30 {ECO:0000312|EMBL:AC016162};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
RN [6]
RP FUNCTION.
RX PubMed=19897604; DOI=10.1104/pp.109.148197;
RA Wang G., Long Y., Thomma B.P.H.J., de Wit P.J.G.M., Angenent G.C.,
RA Fiers M.;
RT "Functional analyses of the CLAVATA2-like proteins and their domains that
RT contribute to CLAVATA2 specificity.";
RL Plant Physiol. 152:320-331(2010).
CC -!- FUNCTION: Involved in the perception of CLV3 and CLV3-like peptides,
CC that act as extracellular signals regulating meristems maintenance.
CC {ECO:0000269|PubMed:19897604}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG51836.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BX817184; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AC016162; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016163; AAG51836.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE35197.1; -; Genomic_DNA.
DR EMBL; BX817184; -; NOT_ANNOTATED_CDS; mRNA.
DR RefSeq; NP_177296.2; NM_105809.4.
DR AlphaFoldDB; Q9C9H7; -.
DR SMR; Q9C9H7; -.
DR STRING; 3702.AT1G71400.1; -.
DR PaxDb; Q9C9H7; -.
DR PRIDE; Q9C9H7; -.
DR ProteomicsDB; 228100; -.
DR EnsemblPlants; AT1G71400.1; AT1G71400.1; AT1G71400.
DR GeneID; 843481; -.
DR Gramene; AT1G71400.1; AT1G71400.1; AT1G71400.
DR KEGG; ath:AT1G71400; -.
DR Araport; AT1G71400; -.
DR TAIR; locus:2825384; AT1G71400.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; Q9C9H7; -.
DR OMA; HTIYYES; -.
DR OrthoDB; 826997at2759; -.
DR PRO; PR:Q9C9H7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C9H7; baseline and differential.
DR Genevisible; Q9C9H7; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010073; P:meristem maintenance; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 2.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 10.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..27
FT /evidence="ECO:0000255"
FT CHAIN 28..847
FT /note="Receptor-like protein 12"
FT /id="PRO_0000401214"
FT TOPO_DOM 28..798
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 799..819
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 820..847
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 109..133
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 135..157
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 158..181
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 183..205
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 206..229
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 231..253
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 254..277
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 279..301
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 302..325
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 326..350
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 351..374
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 375..398
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 400..422
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 424..442
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 443..466
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 467..491
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 492..514
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 516..539
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 541..562
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 563..587
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 589..613
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 657..681
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 682..704
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 705..729
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 731..754
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT CARBOHYD 52
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 66
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 103
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 132
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 180
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 210
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 228
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 263
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 276
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 289
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 346
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 437
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 489
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 503
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 601
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 688
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 736
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 300
FT /note="I -> T (in Ref. 3; BX817184)"
FT /evidence="ECO:0000305"
FT CONFLICT 728
FT /note="A -> E (in Ref. 3; BX817184)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 847 AA; 95284 MW; 0F8ED1EC7C6EC2A6 CRC64;
MMIRSHRHWV FSSRIIIFLS LLVHSLASSS PHFCRDDQRD ALLEFRGEFP INASWHIMNQ
WRGPWNKSTD CCLWNGVTCN DKSGQVISLD IPNTFLNNYL KTNSSLFKLQ YLRHLDLTNC
NLYGEIPSSL GNLSHLTLVN LYFNKFVGEI PASIGNLNQL RHLILANNVL TGEIPSSLGN
LSRLVNLELF SNRLVGKIPD SIGDLKQLRN LSLASNNLIG EIPSSLGNLS NLVHLVLTHN
QLVGEVPASI GNLIELRVMS FENNSLSGNI PISFANLTKL SIFVLSSNNF TSTFPFDMSI
FHNLEYFDVS YNSFSGPFPK SLLLIPSLES IYLQENQFTG PIEFANTSSS TKLQDLILGR
NRLHGPIPES ISRLLNLEEL DISHNNFTGA IPPTISKLVN LLHLDLSKNN LEGEVPACLW
RLNTMVLSHN SFSSFENTSQ EEALIEELDL NSNSFQGPIP YMICKLSSLG FLDLSNNLFS
GSIPSCIRNF SGSIKELNLG DNNFSGTLPD IFSKATELVS LDVSHNQLEG KFPKSLINCK
ALELVNVESN KIKDIFPSWL ESLPSLHVLN LRSNKFYGPL YHRHASIGFQ SLRIIDISHN
NFSGTLPPYY FSNWKDMTTL TEEMDQYMTE FWRYADSYYH EMEMVNKGVD MSFERIRRDF
RAIDFSGNKI NGNIPESLGY LKELRVLNLS GNAFTSVIPR FLANLTKLET LDISRNKLSG
QIPQDLAALS FLSYMNFSHN LLQGPVPRGT QFQRQKCSSF LDNPGLYGLE DICRDTGALN
PTSQLPEDLS EAEENMFNWV AAAIAYGPGV LCGLVIGHFY TSHNHEWFTE KFGRKQHKAL
TSVKCSL
