RLP18_ARATH
ID RLP18_ARATH Reviewed; 826 AA.
AC Q9ZUK7; F4IHG3;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 3.
DT 03-AUG-2022, entry version 99.
DE RecName: Full=Receptor-like protein 18 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP18 {ECO:0000303|PubMed:18434605};
GN Name=RLP18 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At2g15040/At2g15042 {ECO:0000312|Araport:AT2G15040,
GN ECO:0000312|Araport:AT2G15042};
GN ORFNames=T15J14.8 {ECO:0000312|EMBL:AAD03361.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-343, AND NUCLEOTIDE SEQUENCE
RP [LARGE SCALE MRNA] OF 601-750.
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [5]
RP GENE FAMILY, NOMENCLATURE, AND DISRUPTION PHENOTYPE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- DISRUPTION PHENOTYPE: Enhanced susceptibility to pathogen Pseudomonas
CC syringae pv. phaseolicola. {ECO:0000269|PubMed:18434605}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- CAUTION: Lacks the signal peptide, which is a conserved feature of the
CC gene family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAD03361.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AEC06363.2; Type=Erroneous gene model prediction; Note=Was originally thought to correspond to two different genes At2g15040 and At5g15042.; Evidence={ECO:0000305};
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DR EMBL; AC005957; AAD03361.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC06363.2; ALT_SEQ; Genomic_DNA.
DR EMBL; BX819827; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; BX821852; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; C84524; C84524.
DR RefSeq; NP_001318226.1; NM_001335446.1.
DR AlphaFoldDB; Q9ZUK7; -.
DR SMR; Q9ZUK7; -.
DR STRING; 3702.AT2G15042.1; -.
DR PeptideAtlas; Q9ZUK7; -.
DR PRIDE; Q9ZUK7; -.
DR GeneID; 7922469; -.
DR KEGG; ath:AT2G15042; -.
DR Araport; AT2G15040; -.
DR Araport; AT2G15042; -.
DR TAIR; locus:5019474716; AT2G15042.
DR eggNOG; KOG0619; Eukaryota.
DR OrthoDB; 826997at2759; -.
DR PRO; PR:Q9ZUK7; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q9ZUK7; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR GO; GO:0002758; P:innate immune response-activating signal transduction; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 5.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 2.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 7.
DR PROSITE; PS51450; LRR; 18.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Plant defense;
KW Reference proteome; Repeat; Transmembrane; Transmembrane helix.
FT CHAIN 1..826
FT /note="Receptor-like protein 18"
FT /id="PRO_0000443480"
FT TOPO_DOM 1..780
FT /note="Extracellular"
FT /evidence="ECO:0000305"
FT TRANSMEM 781..801
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 802..826
FT /note="Cytoplasmic"
FT /evidence="ECO:0000305"
FT REPEAT 5..31
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 32..54
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 55..79
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 81..103
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 104..127
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 128..150
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 151..177
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 178..198
FT /note="LRR 8; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 199..223
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 225..247
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 248..271
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 273..294
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 296..318
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 319..343
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 345..368
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 382..405
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 406..429
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 430..452
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 455..478
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 479..500
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 501..524
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 525..550
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 552..570
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 571..594
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 637..661
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 662..685
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 686..709
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT REPEAT 711..734
FT /note="LRR 28"
FT /evidence="ECO:0000255"
FT CARBOHYD 12
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 54
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 102
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 126
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 150
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 198
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 219
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 268
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 312
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 331
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 362
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 439
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 467
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 498
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 538
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 584
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 594
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 668
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 716
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 736
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CONFLICT 175
FT /note="F -> L (in Ref. 3; BX819827)"
FT /evidence="ECO:0000305"
FT CONFLICT 229
FT /note="F -> S (in Ref. 3; BX819827)"
FT /evidence="ECO:0000305"
FT CONFLICT 324
FT /note="D -> N (in Ref. 1; AAD03361)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 826 AA; 91225 MW; 4C12ED1DAECFF889 CRC64;
MRCQVWNVIE LNLSSSCLHG LLNSKSNIFS LQNLRFLDLS NNHFSGQILS SLGNFSSLTT
LDLSENHFSG QIPSSLGNLL HLTSLDLTDN NFVGDIPTSL GNLSHLTLLL LGANNLVGEI
PFSLGNLSHL TDLTLCENDL AGEIPSSFEN LSHLTNLDLS QNNLVGEIPS FFGSFNQLVS
LAVEENEFTG NFLLILLNLT NLSDLSLSRN QFTGTLPPNM SSLSNLVLFY ADANAFTGTI
PSSLLNIPSL SCFDLSDNQL NGNIEFGNIS SSLSDLLLGN NNFRGSIHKS ISKLVNLYTL
DLSHFNTQGS INFSIFSDLK LLVDLHLSHL NTTTTIDLNT FLSSFKSLDT LDLSGNHISA
INKSSVSNPV TTARPGLGLT NPLLLSRFNL SGCGVTEFPE FLRTQQTMEI LDISNNKING
QVPGWLWTLP TLDYVNLSNN TFTGFQRLMV PSSWQPSMNY FSGANNNFTG NLPAFICAFT
LQALHLRKNH LSGVFPENIS ESLKSLDVGH NQLVGKLPRS LVRISSLEVL NVENNKINDT
FPFWLSSLEE LQVLVLRSNA FHGPMQQTRF PNLRIIDVSH NHFNGTLPSD FFVNWTVMFL
LGENEDQFNG EYMGTSYYSD SIVVMNKGLE MEMVRILKIF TSVDFSRNKF EGEIPKSIGL
LKELHVLNLS SNTFTGHIPS SMGKLRELES LDVAQNKLSG DIPQDLGDLS YLAYMNFSHN
QLVGPLPGGT QFLTQNCSSF EENAGHFGPS LEKVCDIHGK TMQESEMPGS EEDEEEVISW
IAATIGFIPG IAFGLMMGYI LVCYKPEWFM NVFGKNKSRS TSSTTR
