RLP1_SCHPO
ID RLP1_SCHPO Reviewed; 363 AA.
AC O74331;
DT 24-JAN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 25-MAY-2022, entry version 108.
DE RecName: Full=DNA repair protein rlp1;
DE AltName: Full=RecA-like protein 1;
GN Name=rlp1 {ECO:0000312|EMBL:CAA20059.1}; ORFNames=SPBC1685.11;
OS Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Schizosaccharomycetes; Schizosaccharomycetales; Schizosaccharomycetaceae;
OC Schizosaccharomyces.
OX NCBI_TaxID=284812;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=972 / ATCC 24843;
RX PubMed=11859360; DOI=10.1038/nature724;
RA Wood V., Gwilliam R., Rajandream M.A., Lyne M.H., Lyne R., Stewart A.,
RA Sgouros J.G., Peat N., Hayles J., Baker S.G., Basham D., Bowman S.,
RA Brooks K., Brown D., Brown S., Chillingworth T., Churcher C.M., Collins M.,
RA Connor R., Cronin A., Davis P., Feltwell T., Fraser A., Gentles S.,
RA Goble A., Hamlin N., Harris D.E., Hidalgo J., Hodgson G., Holroyd S.,
RA Hornsby T., Howarth S., Huckle E.J., Hunt S., Jagels K., James K.D.,
RA Jones L., Jones M., Leather S., McDonald S., McLean J., Mooney P.,
RA Moule S., Mungall K.L., Murphy L.D., Niblett D., Odell C., Oliver K.,
RA O'Neil S., Pearson D., Quail M.A., Rabbinowitsch E., Rutherford K.M.,
RA Rutter S., Saunders D., Seeger K., Sharp S., Skelton J., Simmonds M.N.,
RA Squares R., Squares S., Stevens K., Taylor K., Taylor R.G., Tivey A.,
RA Walsh S.V., Warren T., Whitehead S., Woodward J.R., Volckaert G., Aert R.,
RA Robben J., Grymonprez B., Weltjens I., Vanstreels E., Rieger M.,
RA Schaefer M., Mueller-Auer S., Gabel C., Fuchs M., Duesterhoeft A.,
RA Fritzc C., Holzer E., Moestl D., Hilbert H., Borzym K., Langer I., Beck A.,
RA Lehrach H., Reinhardt R., Pohl T.M., Eger P., Zimmermann W., Wedler H.,
RA Wambutt R., Purnelle B., Goffeau A., Cadieu E., Dreano S., Gloux S.,
RA Lelaure V., Mottier S., Galibert F., Aves S.J., Xiang Z., Hunt C.,
RA Moore K., Hurst S.M., Lucas M., Rochet M., Gaillardin C., Tallada V.A.,
RA Garzon A., Thode G., Daga R.R., Cruzado L., Jimenez J., Sanchez M.,
RA del Rey F., Benito J., Dominguez A., Revuelta J.L., Moreno S.,
RA Armstrong J., Forsburg S.L., Cerutti L., Lowe T., McCombie W.R.,
RA Paulsen I., Potashkin J., Shpakovski G.V., Ussery D., Barrell B.G.,
RA Nurse P.;
RT "The genome sequence of Schizosaccharomyces pombe.";
RL Nature 415:871-880(2002).
RN [2] {ECO:0000305}
RP FUNCTION.
RX PubMed=14668362; DOI=10.1093/genetics/165.3.1031;
RA Grishchuk A.L., Kohli J.;
RT "Five RecA-like proteins of Schizosaccharomyces pombe are involved in
RT meiotic recombination.";
RL Genetics 165:1031-1043(2003).
RN [3] {ECO:0000305}
RP FUNCTION.
RX PubMed=15336631; DOI=10.1016/j.dnarep.2004.05.010;
RA Khasanov F.K., Salakhova A.F., Chepurnaja O.V., Korolev V.G.,
RA Bashkirov V.I.;
RT "Identification and characterization of the rlp1+, the novel Rad51 paralog
RT in the fission yeast Schizosaccharomyces pombe.";
RL DNA Repair 3:1363-1374(2004).
RN [4]
RP FUNCTION, INTERACTION WITH RDL1 AND SWS1, AND SUBCELLULAR LOCATION.
RX PubMed=16710300; DOI=10.1038/sj.emboj.7601141;
RA Martin V., Chahwan C., Gao H., Blais V., Wohlschlegel J., Yates J.R. III,
RA McGowan C.H., Russell P.;
RT "Sws1 is a conserved regulator of homologous recombination in eukaryotic
RT cells.";
RL EMBO J. 25:2564-2574(2006).
RN [5]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RX PubMed=16823372; DOI=10.1038/nbt1222;
RA Matsuyama A., Arai R., Yashiroda Y., Shirai A., Kamata A., Sekido S.,
RA Kobayashi Y., Hashimoto A., Hamamoto M., Hiraoka Y., Horinouchi S.,
RA Yoshida M.;
RT "ORFeome cloning and global analysis of protein localization in the fission
RT yeast Schizosaccharomyces pombe.";
RL Nat. Biotechnol. 24:841-847(2006).
CC -!- FUNCTION: Required for normal levels of meiotic recombination. Acts in
CC the recombinational pathway of double-strand break (DSB) repair
CC together with rhp51, rhp55 and rad22. Required for the full extent of
CC DNA recombination and cell survival under condition of a replication
CC fork collapse. {ECO:0000269|PubMed:14668362,
CC ECO:0000269|PubMed:15336631, ECO:0000269|PubMed:16710300}.
CC -!- SUBUNIT: Interacts with rdl1 and sws1. {ECO:0000269|PubMed:16710300}.
CC -!- INTERACTION:
CC O74331; O13600: sws1; NbExp=2; IntAct=EBI-8527133, EBI-8527040;
CC -!- SUBCELLULAR LOCATION: Cytoplasm. Nucleus.
CC -!- SIMILARITY: Belongs to the RecA family. RAD51 subfamily. {ECO:0000305}.
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DR EMBL; CU329671; CAA20059.1; -; Genomic_DNA.
DR PIR; T39527; T39527.
DR RefSeq; NP_595215.1; NM_001021122.2.
DR AlphaFoldDB; O74331; -.
DR BioGRID; 276321; 25.
DR IntAct; O74331; 3.
DR MINT; O74331; -.
DR STRING; 4896.SPBC1685.11.1; -.
DR PaxDb; O74331; -.
DR EnsemblFungi; SPBC1685.11.1; SPBC1685.11.1:pep; SPBC1685.11.
DR GeneID; 2539770; -.
DR KEGG; spo:SPBC1685.11; -.
DR PomBase; SPBC1685.11; rlp1.
DR VEuPathDB; FungiDB:SPBC1685.11; -.
DR HOGENOM; CLU_776492_0_0_1; -.
DR InParanoid; O74331; -.
DR OMA; ASKMLGC; -.
DR PRO; PR:O74331; -.
DR Proteomes; UP000002485; Chromosome II.
DR GO; GO:0005829; C:cytosol; HDA:PomBase.
DR GO; GO:0005634; C:nucleus; HDA:PomBase.
DR GO; GO:0016887; F:ATP hydrolysis activity; NAS:PomBase.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IMP:PomBase.
DR GO; GO:0006312; P:mitotic recombination; IMP:PomBase.
DR GO; GO:0007131; P:reciprocal meiotic recombination; IMP:PomBase.
DR GO; GO:0000725; P:recombinational repair; IMP:PomBase.
DR Gene3D; 3.40.50.300; -; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR SUPFAM; SSF52540; SSF52540; 1.
PE 1: Evidence at protein level;
KW Cytoplasm; DNA damage; DNA recombination; DNA repair; Meiosis; Nucleus;
KW Reference proteome.
FT CHAIN 1..363
FT /note="DNA repair protein rlp1"
FT /id="PRO_0000122947"
SQ SEQUENCE 363 AA; 41654 MW; C11EC18349BE792A CRC64;
MNAAEWVAEL KRKSQIESFK EQKGLVYDDH IEKVLYSGSV NGTLLVIEGN SCSGKTELLY
HLASNVLLRS SQELVLIVSS EWDWSIKRLT FILHERLISS RGVSQTCKCN CAVKLENEST
VHLQNAARED GTDEDINSNS VNDVSLSSGE TMLQFPEHEE QHECNREMEQ LYESASSTVY
PCSFWEDAER KIDAQCAILW PMEFSGVVES IPQSTKDLLR IWKEAKIQMH EDFRCNKTEF
NEACFDASSS RLGCILMDGL STFYWQLRLE RGYTQVYADL QNRLCTSSKL FGCPVVCTNW
LLNNKQHLPI QCKRFRSERR ANARFYLENC VSKLGETFYL SVKGVQTKTE MASPYSQQEM
EKV
