RLP23_ARATH
ID RLP23_ARATH Reviewed; 890 AA.
AC O48849;
DT 28-MAR-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1998, sequence version 1.
DT 25-MAY-2022, entry version 147.
DE RecName: Full=Receptor like protein 23 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP23 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP23 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At2g32680 {ECO:0000312|Araport:AT2G32680};
GN ORFNames=F24L7.18 {ECO:0000312|EMBL:AAC04495.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
RN [5]
RP REVIEW.
RX PubMed=25064074; DOI=10.1016/j.pbi.2014.07.007;
RA Gust A.A., Felix G.;
RT "Receptor like proteins associate with SOBIR1-type of adaptors to form
RT bimolecular receptor kinases.";
RL Curr. Opin. Plant Biol. 21:104-111(2014).
RN [6]
RP IDENTIFICATION BY MASS SPECTROMETRY, AND INTERACTION WITH SOBIR1.
RX PubMed=24525519; DOI=10.4161/psb.27937;
RA Bi G., Liebrand T.W., Cordewener J.H., America A.H., Xu X., Joosten M.H.;
RT "Arabidopsis thaliana receptor-like protein AtRLP23 associates with the
RT receptor-like kinase AtSOBIR1.";
RL Plant Signal. Behav. 9:E27937-E27937(2014).
RN [7]
RP FUNCTION, SUBUNIT, DISRUPTION PHENOTYPE, AND COMPONENT OF THE
RP RLP23-SOBIR1-BAK1 COMPLEX.
RX PubMed=27251392; DOI=10.1038/nplants.2015.140;
RA Albert I., Boehm H., Albert M., Feiler C.E., Imkampe J., Wallmeroth N.,
RA Brancato C., Raaymakers T.M., Oome S., Zhang H., Krol E., Grefen C.,
RA Gust A.A., Chai J., Hedrich R., Van den Ackerveken G., Nuernberger T.;
RT "An RLP23-SOBIR1-BAK1 complex mediates NLP-triggered immunity.";
RL Nat. Plants 1:15140-15140(2015).
RN [8]
RP INDUCTION BY MANNITOL.
RX PubMed=27099374; DOI=10.1093/jxb/erw152;
RA Wu J., Liu Z., Zhang Z., Lv Y., Yang N., Zhang G., Wu M., Lv S., Pan L.,
RA Joosten M.H., Wang G.;
RT "Transcriptional regulation of receptor-like protein genes by environmental
RT stresses and hormones and their overexpression activities in Arabidopsis
RT thaliana.";
RL J. Exp. Bot. 67:3339-3351(2016).
CC -!- FUNCTION: Involved in the perception of necrosis and ethylene-inducing
CC peptide 1-like proteins (NLPs), that act as extracellular signals
CC mediating immune activation. Component of the RLP23-SOBIR1-BAK1 complex
CC that mediates NLP-triggered immunity. {ECO:0000269|PubMed:27251392}.
CC -!- SUBUNIT: Directly interacts with a 20-mer fragment (nlp20) from NLPs
CC through its extracellular LRR domain. Component of a trimeric complex
CC composed of RLP23, SOBIR1 and BAK1. BAK1 is recruited into a pre-formed
CC RLP23-SOBIR1 complex in a ligand-dependent manner (PubMed:27251392).
CC Interacts with SOBIR1 (PubMed:24525519, PubMed:27251392).
CC {ECO:0000269|PubMed:24525519, ECO:0000269|PubMed:27251392}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- INDUCTION: By mannitol. {ECO:0000269|PubMed:27099374}.
CC -!- DISRUPTION PHENOTYPE: Impaired in nlp20-mediated immunity.
CC {ECO:0000269|PubMed:27251392}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR EMBL; AC003974; AAC04495.1; -; Genomic_DNA.
DR EMBL; CP002685; AEC08715.1; -; Genomic_DNA.
DR PIR; T00800; T00800.
DR RefSeq; NP_180827.1; NM_128827.2.
DR AlphaFoldDB; O48849; -.
DR SMR; O48849; -.
DR STRING; 3702.AT2G32680.1; -.
DR PaxDb; O48849; -.
DR PRIDE; O48849; -.
DR ProteomicsDB; 227996; -.
DR EnsemblPlants; AT2G32680.1; AT2G32680.1; AT2G32680.
DR GeneID; 817828; -.
DR Gramene; AT2G32680.1; AT2G32680.1; AT2G32680.
DR KEGG; ath:AT2G32680; -.
DR Araport; AT2G32680; -.
DR TAIR; locus:2046357; AT2G32680.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; O48849; -.
DR OMA; ISSERWD; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; O48849; -.
DR PRO; PR:O48849; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; O48849; baseline and differential.
DR GO; GO:0005783; C:endoplasmic reticulum; HDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0019901; F:protein kinase binding; IPI:UniProtKB.
DR GO; GO:0042742; P:defense response to bacterium; IMP:UniProtKB.
DR GO; GO:0050832; P:defense response to fungus; IMP:UniProtKB.
DR GO; GO:0002229; P:defense response to oomycetes; IMP:UniProtKB.
DR GO; GO:0032491; P:detection of molecule of fungal origin; IMP:UniProtKB.
DR GO; GO:0002758; P:innate immune response-activating signal transduction; IMP:UniProtKB.
DR GO; GO:0140426; P:PAMP-triggered immunity signalling pathway; IMP:TAIR.
DR GO; GO:0010555; P:response to mannitol; IMP:UniProtKB.
DR GO; GO:0002237; P:response to molecule of bacterial origin; IMP:UniProtKB.
DR GO; GO:0002238; P:response to molecule of fungal origin; IMP:UniProtKB.
DR GO; GO:0002240; P:response to molecule of oomycetes origin; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 1.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13516; LRR_6; 1.
DR Pfam; PF13855; LRR_8; 3.
DR SMART; SM00369; LRR_TYP; 10.
DR PROSITE; PS51450; LRR; 15.
PE 1: Evidence at protein level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Plant defense;
KW Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..890
FT /note="Receptor like protein 23"
FT /id="PRO_5011945105"
FT TOPO_DOM 23..850
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 851..871
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 872..890
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 97..121
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 123..145
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 146..171
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 173..195
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 196..218
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 220..243
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 244..268
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 270..290
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 291..316
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 318..339
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 340..363
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 364..389
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 391..411
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 412..436
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 438..461
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 462..485
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 487..506
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 507..527
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 528..551
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 553..575
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 577..598
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 599..623
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 626..650
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 699..724
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 726..747
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 748..771
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 773..796
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT CARBOHYD 58
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 70
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 91
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 189
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 242
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 265
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 311
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 351
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 461
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 505
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 518
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 574
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 730
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 778
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 890 AA; 98482 MW; 297578445B6357EF CRC64;
MSKALLHLHF LSLFLLCCVC HSSIFTLNFH FTGIVACRPH QIQAFTKFTN EFDTRGCNNS
DTFNGVWCDN STGAVAVLQL RKCLSGTLKS NSSLFGFHQL RYVDLQNNNL TSSSLPSGFG
NLKRLEGLFL SSNGFLGQVP SSFSNLTMLA QLDLSYNKLT GSFPLVRGLR KLIVLDLSYN
HFSGTLNPNS SLFELHQLRY LNLAFNNFSS SLPSKFGNLH RLENLILSSN GFSGQVPSTI
SNLTRLTKLY LDQNKLTSSF PLVQNLTNLY ELDLSYNKFF GVIPSSLLTL PFLAHLALRE
NNLAGSVEVS NSSTSSRLEI MYLGSNHFEG QILEPISKLI NLKHLDLSFL NTSYPIDLKL
FSSLKSLRSL DLSGNSISSA SLSSDSYIPL TLEMLTLRHC DINEFPNILK TLKELVYIDI
SNNRMKGKIP EWLWSLPLLQ SVTLGNNYFT GFQGSAEILV NSSVLLLYLD SNNFEGALPD
LPLSIKGFGV ASNSFTSEIP LSICNRSSLA AIDLSYNNFT GPIPPCLRNL ELVYLRNNNL
EGSIPDALCD GASLRTLDVS HNRLTGKLPR SFVNCSSLKF LSVINNRIED TFPFWLKALP
NLQVLTLRSN RFYGPISPPH QGPLGFPELR IFEISDNKFT GSLPPNYFVN WKASSRTMNQ
DGGLYMVYEE KLFDEGGYGY TDALDLQYKG LHMEQAKALT SYAAIDFSGN RLEGQIPESI
GLLKALIAVN ISNNAFTGHI PLSMANLENL ESLDMSRNQL SGTIPNGLGS ISFLAYINVS
HNQLTGEIPQ GTQITGQSKS SFEGNAGLCG LPLKESCFGT GAPPMYHQKQ EDKEEEEEEE
EEEEEVLNGR AVAIGYGSGL LLGLAIAQVI ASYKPEWLVK IIGLNKRRKR
