RLP24_HUMAN
ID RLP24_HUMAN Reviewed; 163 AA.
AC Q9UHA3; B2RD72; Q561V8; Q8N6S8; Q96B04; Q96C76; Q96HJ1;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Probable ribosome biogenesis protein RLP24;
DE AltName: Full=Ribosomal L24 domain-containing protein 1;
DE AltName: Full=Ribosomal protein L24-like;
GN Name=RSL24D1; Synonyms=C15orf15, RPL24L; ORFNames=My024;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Dendritic cell;
RA Li Y., Peng Y., Li N., Gu W., Han Z., Fu G., Chen Z.;
RT "Novel genes expressed in human dendritic cells.";
RL Submitted (NOV-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Fetal brain;
RA Mao Y.M., Xie Y., Lin Q., Mu Z.M., Yuan Y.Z.;
RL Submitted (APR-1998) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Hematopoietic stem cell;
RA Gu J., Huang Q., Yu Y., Xu S., Wang Y., Han Z., Chen Z., Zhou J., Tu Y.,
RA Gu W., Fu G., Huang C.;
RT "Novel genes expressed in hematopoietic stem/progenitor cells from
RT myelodysplastic syndrome patients.";
RL Submitted (JUL-1999) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Liver;
RA Peng Y., Li Y., Tu Y., Xu S., Han Z., Fu G., Chen Z.;
RT "A novel gene expressed in human liver.";
RL Submitted (DEC-1999) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.;
RT "Cloning of human full open reading frames in Gateway(TM) system entry
RT vector (pDONR201).";
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [7]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [8]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Blood, Bone marrow, Brain, Lung, and Urinary bladder;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [9]
RP SUBCELLULAR LOCATION [LARGE SCALE ANALYSIS].
RC TISSUE=Cervix carcinoma;
RX PubMed=12429849; DOI=10.1091/mbc.e02-05-0271;
RA Scherl A., Coute Y., Deon C., Calle A., Kindbeiter K., Sanchez J.-C.,
RA Greco A., Hochstrasser D.F., Diaz J.-J.;
RT "Functional proteomic analysis of human nucleolus.";
RL Mol. Biol. Cell 13:4100-4109(2002).
RN [10]
RP SUBCELLULAR LOCATION.
RX PubMed=35354024; DOI=10.1016/j.celrep.2022.110597;
RA Ni C., Schmitz D.A., Lee J., Pawlowski K., Wu J., Buszczak M.;
RT "Labeling of heterochronic ribosomes reveals C1ORF109 and SPATA5 control a
RT late step in human ribosome assembly.";
RL Cell Rep. 38:110597-110597(2022).
RN [11] {ECO:0007744|PDB:6LSS, ECO:0007744|PDB:6LU8}
RP STRUCTURE BY ELECTRON MICROSCOPY (3.13 ANGSTROMS) IN COMPLEX WITH PRE-60S
RP RIBOSOMAL PARTICLES, AND INTERACTION WITH PRE-60S RIBOSOMAL PARTICLES.
RX PubMed=32669547; DOI=10.1038/s41467-020-17237-x;
RA Liang X., Zuo M.Q., Zhang Y., Li N., Ma C., Dong M.Q., Gao N.;
RT "Structural snapshots of human pre-60S ribosomal particles before and after
RT nuclear export.";
RL Nat. Commun. 11:3542-3542(2020).
CC -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC Ensures the docking of GTPBP4/NOG1 to pre-60S particles (By
CC similarity). {ECO:0000250|UniProtKB:Q07915}.
CC -!- SUBUNIT: Associated with nucleolar and cytoplasmic pre-60S particles
CC (PubMed:32669547). At the end of biogenesis it dissociates from
CC cytoplasmic pre-60S particles and is likely to be exchanged for its
CC ribosomal homolog, RPL24 (By similarity).
CC {ECO:0000250|UniProtKB:Q07915, ECO:0000269|PubMed:32669547}.
CC -!- INTERACTION:
CC Q9UHA3; Q9UJX2: CDC23; NbExp=3; IntAct=EBI-749321, EBI-396137;
CC Q9UHA3; Q9UJW3: DNMT3L; NbExp=7; IntAct=EBI-749321, EBI-740967;
CC Q9UHA3; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-749321, EBI-10175124;
CC -!- SUBCELLULAR LOCATION: Nucleus, nucleolus {ECO:0000269|PubMed:12429849,
CC ECO:0000269|PubMed:35354024}.
CC -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.
CC {ECO:0000305}.
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DR EMBL; AF201949; AAF17241.1; -; mRNA.
DR EMBL; AF060926; AAG43138.1; -; mRNA.
DR EMBL; AF165521; AAF86651.1; -; mRNA.
DR EMBL; AF212226; AAK26249.1; -; mRNA.
DR EMBL; CR457179; CAG33460.1; -; mRNA.
DR EMBL; AK315431; BAG37819.1; -; mRNA.
DR EMBL; CH471082; EAW77473.1; -; Genomic_DNA.
DR EMBL; BC008409; AAH08409.1; -; mRNA.
DR EMBL; BC008422; AAH08422.1; -; mRNA.
DR EMBL; BC008449; AAH08449.1; -; mRNA.
DR EMBL; BC008499; AAH08499.1; -; mRNA.
DR EMBL; BC009593; AAH09593.1; -; mRNA.
DR EMBL; BC009604; AAH09604.1; -; mRNA.
DR EMBL; BC012913; AAH12913.1; -; mRNA.
DR EMBL; BC014576; AAH14576.1; -; mRNA.
DR EMBL; BC016312; AAH16312.1; -; mRNA.
DR EMBL; BC016331; AAH16331.1; -; mRNA.
DR EMBL; BC016725; AAH16725.1; -; mRNA.
DR EMBL; BC016777; AAH16777.1; -; mRNA.
DR EMBL; BC026266; AAH26266.1; -; mRNA.
DR EMBL; BC026267; AAH26267.1; -; mRNA.
DR EMBL; BC028672; AAH28672.1; -; mRNA.
DR EMBL; BC035995; AAH35995.1; -; mRNA.
DR EMBL; BC093067; AAH93067.1; -; mRNA.
DR CCDS; CCDS10152.1; -.
DR RefSeq; NP_057388.1; NM_016304.2.
DR PDB; 6LSS; EM; 3.23 A; 7=1-163.
DR PDB; 6LU8; EM; 3.13 A; 7=1-163.
DR PDBsum; 6LSS; -.
DR PDBsum; 6LU8; -.
DR AlphaFoldDB; Q9UHA3; -.
DR SMR; Q9UHA3; -.
DR BioGRID; 119362; 107.
DR CORUM; Q9UHA3; -.
DR IntAct; Q9UHA3; 21.
DR MINT; Q9UHA3; -.
DR STRING; 9606.ENSP00000260443; -.
DR DrugBank; DB02494; (S)-3-phenyllactic acid.
DR DrugBank; DB07374; Anisomycin.
DR DrugBank; DB08437; Puromycin.
DR iPTMnet; Q9UHA3; -.
DR PhosphoSitePlus; Q9UHA3; -.
DR BioMuta; RSL24D1; -.
DR DMDM; 52783333; -.
DR SWISS-2DPAGE; Q9UHA3; -.
DR EPD; Q9UHA3; -.
DR jPOST; Q9UHA3; -.
DR MassIVE; Q9UHA3; -.
DR MaxQB; Q9UHA3; -.
DR PaxDb; Q9UHA3; -.
DR PeptideAtlas; Q9UHA3; -.
DR PRIDE; Q9UHA3; -.
DR ProteomicsDB; 84291; -.
DR Antibodypedia; 25045; 77 antibodies from 18 providers.
DR DNASU; 51187; -.
DR Ensembl; ENST00000260443.9; ENSP00000260443.4; ENSG00000137876.11.
DR GeneID; 51187; -.
DR KEGG; hsa:51187; -.
DR MANE-Select; ENST00000260443.9; ENSP00000260443.4; NM_016304.3; NP_057388.1.
DR UCSC; uc002acn.4; human.
DR CTD; 51187; -.
DR GeneCards; RSL24D1; -.
DR HGNC; HGNC:18479; RSL24D1.
DR HPA; ENSG00000137876; Low tissue specificity.
DR MIM; 613262; gene.
DR neXtProt; NX_Q9UHA3; -.
DR OpenTargets; ENSG00000137876; -.
DR PharmGKB; PA164725551; -.
DR VEuPathDB; HostDB:ENSG00000137876; -.
DR eggNOG; KOG1723; Eukaryota.
DR GeneTree; ENSGT00950000183105; -.
DR HOGENOM; CLU_089419_2_2_1; -.
DR InParanoid; Q9UHA3; -.
DR OMA; RERQFYK; -.
DR OrthoDB; 1502432at2759; -.
DR PhylomeDB; Q9UHA3; -.
DR TreeFam; TF314926; -.
DR PathwayCommons; Q9UHA3; -.
DR SignaLink; Q9UHA3; -.
DR BioGRID-ORCS; 51187; 747 hits in 1010 CRISPR screens.
DR ChiTaRS; RSL24D1; human.
DR GeneWiki; C15orf15; -.
DR GenomeRNAi; 51187; -.
DR Pharos; Q9UHA3; Tbio.
DR PRO; PR:Q9UHA3; -.
DR Proteomes; UP000005640; Chromosome 15.
DR RNAct; Q9UHA3; protein.
DR Bgee; ENSG00000137876; Expressed in germinal epithelium of ovary and 204 other tissues.
DR ExpressionAtlas; Q9UHA3; baseline and differential.
DR Genevisible; Q9UHA3; HS.
DR GO; GO:0005730; C:nucleolus; IDA:HPA.
DR GO; GO:0005654; C:nucleoplasm; IDA:HPA.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0042273; P:ribosomal large subunit biogenesis; IBA:GO_Central.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR CDD; cd00472; Ribosomal_L24e_L24; 1.
DR Gene3D; 2.30.170.20; -; 1.
DR HAMAP; MF_00773; Ribosomal_L24e; 1.
DR InterPro; IPR038630; L24e/L24_sf.
DR InterPro; IPR023438; Ribosomal_L24e.
DR InterPro; IPR000988; Ribosomal_L24e-rel.
DR InterPro; IPR023442; Ribosomal_L24e_CS.
DR InterPro; IPR011017; TRASH_dom.
DR PANTHER; PTHR10792; PTHR10792; 1.
DR Pfam; PF01246; Ribosomal_L24e; 1.
DR SMART; SM00746; TRASH; 1.
DR PROSITE; PS01073; RIBOSOMAL_L24E; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Nucleus; Reference proteome; Ribosome biogenesis.
FT CHAIN 1..163
FT /note="Probable ribosome biogenesis protein RLP24"
FT /id="PRO_0000136896"
FT CONFLICT 29
FT /note="F -> I (in Ref. 8; AAH08499)"
FT /evidence="ECO:0000305"
FT CONFLICT 30
FT /note="R -> G (in Ref. 8; AAH14576)"
FT /evidence="ECO:0000305"
FT CONFLICT 45
FT /note="N -> D (in Ref. 8; AAH28672)"
FT /evidence="ECO:0000305"
FT CONFLICT 86
FT /note="W -> R (in Ref. 8; AAH16312)"
FT /evidence="ECO:0000305"
FT CONFLICT 146
FT /note="E -> G (in Ref. 8; AAH28672)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 163 AA; 19621 MW; 1E5D9ECFFCF678D1 CRC64;
MRIEKCYFCS GPIYPGHGMM FVRNDCKVFR FCKSKCHKNF KKKRNPRKVR WTKAFRKAAG
KELTVDNSFE FEKRRNEPIK YQRELWNKTI DAMKRVEEIK QKRQAKFIMN RLKKNKELQK
VQDIKEVKQN IHLIRAPLAG KGKQLEEKMV QQLQEDVDME DAP
