ID   RLP24_KLULA             Reviewed;         198 AA.
AC   Q6CNW3;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=Ribosome biogenesis protein RLP24;
GN   Name=RLP24; OrderedLocusNames=KLLA0E09416g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Involved in the biogenesis of the 60S ribosomal subunit.
CC       Ensures the docking of NOG1 to pre-60S particles. Activates and
CC       recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:Q07915}.
CC   -!- SUBUNIT: Associated with nucleolar and cytoplasmic pre-60S particles.
CC       At the end of biogenesis it dissociates from cytoplasmic pre-60S
CC       particles and is likely to be exchanged for its ribosomal homolog,
CC       RPL24. {ECO:0000250|UniProtKB:Q07915}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q07915}. Nucleus
CC       {ECO:0000250|UniProtKB:Q07915}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:Q07915}.
CC   -!- SIMILARITY: Belongs to the eukaryotic ribosomal protein eL24 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; CR382125; CAG99463.1; -; Genomic_DNA.
DR   RefSeq; XP_454376.1; XM_454376.1.
DR   AlphaFoldDB; Q6CNW3; -.
DR   SMR; Q6CNW3; -.
DR   STRING; 28985.XP_454376.1; -.
DR   EnsemblFungi; CAG99463; CAG99463; KLLA0_E09439g.
DR   GeneID; 2894765; -.
DR   KEGG; kla:KLLA0_E09439g; -.
DR   eggNOG; KOG1723; Eukaryota.
DR   HOGENOM; CLU_089419_1_1_1; -.
DR   InParanoid; Q6CNW3; -.
DR   OMA; HNPRKVK; -.
DR   Proteomes; UP000000598; Chromosome E.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IEA:EnsemblFungi.
DR   GO; GO:0030687; C:preribosome, large subunit precursor; IEA:EnsemblFungi.
DR   GO; GO:0001671; F:ATPase activator activity; IEA:EnsemblFungi.
DR   GO; GO:0051117; F:ATPase binding; IEA:EnsemblFungi.
DR   GO; GO:1902626; P:assembly of large subunit precursor of preribosome; IEA:EnsemblFungi.
DR   GO; GO:0032781; P:positive regulation of ATP-dependent activity; IEA:EnsemblFungi.
DR   GO; GO:0042273; P:ribosomal large subunit biogenesis; IEA:EnsemblFungi.
DR   CDD; cd00472; Ribosomal_L24e_L24; 1.
DR   Gene3D; 2.30.170.20; -; 1.
DR   InterPro; IPR038630; L24e/L24_sf.
DR   InterPro; IPR000988; Ribosomal_L24e-rel.
DR   InterPro; IPR011017; TRASH_dom.
DR   PANTHER; PTHR10792; PTHR10792; 1.
DR   Pfam; PF01246; Ribosomal_L24e; 1.
DR   SMART; SM00746; TRASH; 1.
PE   3: Inferred from homology;
KW   Cytoplasm; Nucleus; Reference proteome; Ribosome biogenesis.
FT   CHAIN           1..198
FT                   /note="Ribosome biogenesis protein RLP24"
FT                   /id="PRO_0000136907"
FT   REGION          147..180
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        153..173
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   198 AA;  23447 MW;  F6ABA9816DBF669E CRC64;
     MRVYACHFCS SPCYPGHGIM FVRNDAKEFR FCRSKCHKAF KQRRNPRKLR WTKAFRKAAG
     KELAVDSTLT FAQRRNVPVR YNRELVATTL KAMSRIEEIR QRRERAFYKN RMKGNNERDF
     LRDKALVESN PELLRLREVE LARQAAKEEA IEQASDEEMD IESEAESEVE SESEAEEQLQ
     KQKILLKNKR KNSKRIAF