RLP2_ARATH
ID RLP2_ARATH Reviewed; 729 AA.
AC Q9SHI3;
DT 30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2000, sequence version 1.
DT 03-AUG-2022, entry version 125.
DE RecName: Full=Receptor-like protein 2 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP2 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP2 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At1g17240 {ECO:0000312|Araport:AT1G17240};
GN ORFNames=F20D23.6 {ECO:0000312|EMBL:AAD50026.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
RN [5]
RP FUNCTION.
RX PubMed=19897604; DOI=10.1104/pp.109.148197;
RA Wang G., Long Y., Thomma B.P.H.J., de Wit P.J.G.M., Angenent G.C.,
RA Fiers M.;
RT "Functional analyses of the CLAVATA2-like proteins and their domains that
RT contribute to CLAVATA2 specificity.";
RL Plant Physiol. 152:320-331(2010).
CC -!- FUNCTION: Involved in the perception of CLV3 and CLV3-like peptides,
CC that act as extracellular signals regulating meristems maintenance.
CC {ECO:0000269|PubMed:19897604}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR EMBL; AC007651; AAD50026.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29563.1; -; Genomic_DNA.
DR EMBL; AI998499; -; NOT_ANNOTATED_CDS; mRNA.
DR PIR; F86308; F86308.
DR RefSeq; NP_173167.1; NM_101585.3.
DR AlphaFoldDB; Q9SHI3; -.
DR SMR; Q9SHI3; -.
DR BioGRID; 23535; 1.
DR IntAct; Q9SHI3; 1.
DR STRING; 3702.AT1G17240.1; -.
DR PaxDb; Q9SHI3; -.
DR PRIDE; Q9SHI3; -.
DR EnsemblPlants; AT1G17240.1; AT1G17240.1; AT1G17240.
DR GeneID; 838295; -.
DR Gramene; AT1G17240.1; AT1G17240.1; AT1G17240.
DR KEGG; ath:AT1G17240; -.
DR Araport; AT1G17240; -.
DR TAIR; locus:2020402; AT1G17240.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_22_9_1; -.
DR InParanoid; Q9SHI3; -.
DR PhylomeDB; Q9SHI3; -.
DR PRO; PR:Q9SHI3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9SHI3; baseline and differential.
DR Genevisible; Q9SHI3; AT.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0010073; P:meristem maintenance; IMP:UniProtKB.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR PROSITE; PS51450; LRR; 12.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..44
FT /evidence="ECO:0000255"
FT CHAIN 45..729
FT /note="Receptor-like protein 2"
FT /id="PRO_0000401213"
FT TOPO_DOM 45..707
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 708..728
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 729
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 89..113
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 114..137
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 139..163
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 168..193
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 195..219
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 220..244
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 245..268
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 269..292
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 293..316
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 317..340
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 342..364
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 365..389
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 391..413
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 414..437
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 439..464
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 468..492
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 493..515
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 516..540
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 542..560
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 561..584
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 599..623
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 624..647
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 649..672
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REGION 45..82
FT /note="N-cap"
FT /evidence="ECO:0000250|UniProtKB:Q9SHI4"
FT REGION 690..707
FT /note="C-cap/acidic domain"
FT /evidence="ECO:0000250|UniProtKB:Q9SHI4"
FT CARBOHYD 60
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 71
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 145
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 163
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 202
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 205
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 256
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 288
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 315
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 330
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 339
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 375
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 428
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 564
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 587
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 611
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 622
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 635
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 657
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 705
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 729 AA; 80576 MW; FE74F5BAE5F77CB8 CRC64;
MRSKAKGLVR PLITKPVQPL SSHMHLFLLC ILFLSALFLT LSEAVCNLQD RESLIWFSGN
VSSSVSPLNW NLSIDCCSWE GITCDDSSDS HVTVISLPSR GLSGTLASSV QNIHRLSRLD
LSYNRLSGPL PPGFFSTLDQ LMILNLSYNS FNGELPLEQA FGNESNRFFS IQTLDLSSNL
LEGEILRSSV YLQGTINLIS FNVSNNSFTG PIPSFMCRSS PQLSKLDFSY NDFSGHISQE
LGRCLRLTVL QAGFNNLSGV IPSEIYNLSE LEQLFLPANQ LTGKIDNNIT RLRKLTSLAL
YSNHLEGEIP MDIGNLSSLR SLQLHINNIN GTVPLSLANC TKLVKLNLRV NQLGGGLTEL
EFSQLQSLKV LDLGNNSFTG ALPDKIFSCK SLTAIRFAGN KLTGEISPQV LELESLSFMG
LSDNKLTNIT GALSILQGCR KLSTLILAKN FYDETVPSKE DFLSPDGFPK LRIFGVGACR
LRGEIPAWLI NLNKVEVMDL SMNRFVGSIP GWLGTLPDLF YLDLSDNLLT GELPKELFQL
RALMSQKITE NNYLELPIFL NPNNVTTNQQ YNKLYSFPPT IYIRRNNLTG SIPVEVGQLK
VLHILELLGN NLSGSIPDEL SNLTNLERLD LSNNNLSGSI PWSLTNLNFL SYFNVANNSL
EGPIPSEGQF DTFPKANFEG NPLLCGGVLL TSCKPTRAKE NDELNRTFLM GIAIGYFLSF
VSILVVRAW
