RLP45_ARATH
ID RLP45_ARATH Reviewed; 948 AA.
AC F4J9A8; Q0WL06; Q9SCN7;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 2.
DT 03-AUG-2022, entry version 85.
DE RecName: Full=Receptor-like protein 45 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP45 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP45 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At3g53240 {ECO:0000312|Araport:AT3G53240};
GN ORFNames=T4D2.170 {ECO:0000312|EMBL:CAB64227.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130713; DOI=10.1038/35048706;
RA Salanoubat M., Lemcke K., Rieger M., Ansorge W., Unseld M., Fartmann B.,
RA Valle G., Bloecker H., Perez-Alonso M., Obermaier B., Delseny M.,
RA Boutry M., Grivell L.A., Mache R., Puigdomenech P., De Simone V.,
RA Choisne N., Artiguenave F., Robert C., Brottier P., Wincker P.,
RA Cattolico L., Weissenbach J., Saurin W., Quetier F., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Benes V., Wurmbach E., Drzonek H.,
RA Erfle H., Jordan N., Bangert S., Wiedelmann R., Kranz H., Voss H.,
RA Holland R., Brandt P., Nyakatura G., Vezzi A., D'Angelo M., Pallavicini A.,
RA Toppo S., Simionati B., Conrad A., Hornischer K., Kauer G., Loehnert T.-H.,
RA Nordsiek G., Reichelt J., Scharfe M., Schoen O., Bargues M., Terol J.,
RA Climent J., Navarro P., Collado C., Perez-Perez A., Ottenwaelder B.,
RA Duchemin D., Cooke R., Laudie M., Berger-Llauro C., Purnelle B., Masuy D.,
RA de Haan M., Maarse A.C., Alcaraz J.-P., Cottet A., Casacuberta E.,
RA Monfort A., Argiriou A., Flores M., Liguori R., Vitale D., Mannhaupt G.,
RA Haase D., Schoof H., Rudd S., Zaccaria P., Mewes H.-W., Mayer K.F.X.,
RA Kaul S., Town C.D., Koo H.L., Tallon L.J., Jenkins J., Rooney T., Rizzo M.,
RA Walts A., Utterback T., Fujii C.Y., Shea T.P., Creasy T.H., Haas B.,
RA Maiti R., Wu D., Peterson J., Van Aken S., Pai G., Militscher J.,
RA Sellers P., Gill J.E., Feldblyum T.V., Preuss D., Lin X., Nierman W.C.,
RA Salzberg S.L., White O., Venter J.C., Fraser C.M., Kaneko T., Nakamura Y.,
RA Sato S., Kato T., Asamizu E., Sasamoto S., Kimura T., Idesawa K.,
RA Kawashima K., Kishida Y., Kiyokawa C., Kohara M., Matsumoto M., Matsuno A.,
RA Muraki A., Nakayama S., Nakazaki N., Shinpo S., Takeuchi C., Wada T.,
RA Watanabe A., Yamada M., Yasuda M., Tabata S.;
RT "Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana.";
RL Nature 408:820-822(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14993207; DOI=10.1101/gr.1515604;
RA Castelli V., Aury J.-M., Jaillon O., Wincker P., Clepet C., Menard M.,
RA Cruaud C., Quetier F., Scarpelli C., Schaechter V., Temple G., Caboche M.,
RA Weissenbach J., Salanoubat M.;
RT "Whole genome sequence comparisons and 'full-length' cDNA sequences: a
RT combined approach to evaluate and improve Arabidopsis genome annotation.";
RL Genome Res. 14:406-413(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (JUL-2006) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=F4J9A8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=F4J9A8-2; Sequence=VSP_059569;
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=ANM63480.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB64227.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AL132958; CAB64227.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002686; AEE79052.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM63480.1; ALT_INIT; Genomic_DNA.
DR EMBL; BX822972; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK230403; BAF02201.1; -; mRNA.
DR PIR; T46170; T46170.
DR RefSeq; NP_001325566.1; NM_001339603.1. [F4J9A8-2]
DR RefSeq; NP_190892.3; NM_115184.5. [F4J9A8-2]
DR AlphaFoldDB; F4J9A8; -.
DR SMR; F4J9A8; -.
DR STRING; 3702.AT3G53240.1; -.
DR PaxDb; F4J9A8; -.
DR PRIDE; F4J9A8; -.
DR EnsemblPlants; AT3G53240.1; AT3G53240.1; AT3G53240. [F4J9A8-2]
DR EnsemblPlants; AT3G53240.2; AT3G53240.2; AT3G53240.
DR EnsemblPlants; AT3G53240.3; AT3G53240.3; AT3G53240. [F4J9A8-2]
DR GeneID; 824491; -.
DR Gramene; AT3G53240.1; AT3G53240.1; AT3G53240. [F4J9A8-2]
DR Gramene; AT3G53240.2; AT3G53240.2; AT3G53240.
DR Gramene; AT3G53240.3; AT3G53240.3; AT3G53240. [F4J9A8-2]
DR KEGG; ath:AT3G53240; -.
DR Araport; AT3G53240; -.
DR TAIR; locus:2101943; AT3G53240.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; F4J9A8; -.
DR OMA; RWNGVEC; -.
DR PRO; PR:F4J9A8; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; F4J9A8; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 3.80.10.10; -; 7.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Leucine-rich repeat;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..26
FT /evidence="ECO:0000255"
FT CHAIN 27..948
FT /note="Receptor-like protein 45"
FT /id="PRO_0000444114"
FT TOPO_DOM 27..897
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 898..918
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 919..948
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 106..129
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 135..162
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 163..183
FT /note="LRR 3; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 184..208
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 210..233
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 234..257
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 258..284
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 286..306
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 307..332
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 334..357
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 358..381
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 382..404
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 405..429
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 430..453
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 454..477
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 479..502
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 503..526
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 527..549
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 550..573
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 575..595
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 596..618
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 619..640
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 642..665
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 666..689
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 758..782
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 783..805
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 807..831
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT REPEAT 833..855
FT /note="LRR 28"
FT /evidence="ECO:0000255"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 113
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 183
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 328
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 381
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 392
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 436
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 465
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 608
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 653
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 679
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 688
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 789
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 837
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 842
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 1..57
FT /note="Missing (in isoform 2)"
FT /id="VSP_059569"
FT CONFLICT 235
FT /note="E -> K (in Ref. 3; BX822972)"
FT /evidence="ECO:0000305"
FT CONFLICT 550
FT /note="F -> S (in Ref. 4; BAF02201)"
FT /evidence="ECO:0000305"
FT CONFLICT 555
FT /note="L -> P (in Ref. 4; BAF02201)"
FT /evidence="ECO:0000305"
FT CONFLICT 605
FT /note="H -> L (in Ref. 3; BX822972)"
FT /evidence="ECO:0000305"
FT CONFLICT 755
FT /note="R -> I (in Ref. 3; BX822972)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 948 AA; 107210 MW; 93815D5EAAA2145F CRC64;
MSSSKLMDFG LTWIIMMMIL LQGCRSCIES ERQGLLEIKA YIISVITDPH LDIRRGWMSS
DRSCCHWRRI KCDITSKRVI GISLSLESIR PPDPLPQLNL TFFYPFEELQ SLNLSSGYFK
GWFDERKGGK GLGSLRNLET LDLGVNFYDT SVLPYLNEAV SLKTLILHDN LFKGGFPVQE
LINLTSLEVL DLKFNKFSGQ LPTQELTNLR NLRALDLSNN KFSGSLQKQG ICRLEQLQEL
RLSRNRFEGE IPLCFSRFSK LRVLDLSSNH LSGKIPYFIS DFKSMEYLSL LDNDFEGLFS
LGLITELTEL KVFKLSSRSG MLQIVETNVS GGLQSQLSSI MLSHCNLGKI PGFLWYQQEL
RVIDLSNNIL SGVFPTWLLE NNTELQALLL QNNSFKTLTL PRTMRRLQIL DLSVNNFNNQ
LPKDVGLILA SLRHLNLSNN EFLGNMPSSM ARMENIEFMD LSYNNFSGKL PRNLFTGCYS
LSWLKLSHNR FSGPIIRKSS DETSLITLIM DNNMFTGKIP RTLLNLRMLS VIDLSNNLLT
GTIPRWLGNF FLEVLRISNN RLQGAIPPSL FNIPYLWLLD LSGNFLSGSL PLRSSSDYGY
ILDLHNNNLT GSIPDTLWYG LRLLDLRNNK LSGNIPLFRS TPSISVVLLR ENNLTGKIPV
ELCGLSNVRM LDFAHNRLNE SIPSCVTNLS FGSGGHSNAD SDWYPASLLS NFMEIYTEVY
YESLIVSDRF SLDYSVDFNV QVEFAVKQRY DLYMRGTLNQ MFGLDLSSNE LSGNIPEELG
DLKRVRSLNL SRNSLSGSIP GSFSNLRSIE SLDLSFNKLH GTIPSQLTLL QSLVVFNVSY
NNLSGVIPQG KQFNTFGEKS YLGNFLLCGS PTKRSCGGTT ISSGKEYEDD DESGLLDIVV
LWWSLGTTYV TVMMGFLVFL CFDSPWRRAW FCLVDTFIDR VKDVLGVI
