RLP49_ARATH
ID RLP49_ARATH Reviewed; 844 AA.
AC Q9SVM3; Q8H180;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 23-MAY-2018, sequence version 2.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Receptor-like protein 49 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP49 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP49 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At4g13900 {ECO:0000312|Araport:AT4G13900};
GN ORFNames=F18A5.290 {ECO:0000312|EMBL:CAB36854.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (MAR-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9SVM3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9SVM3-2; Sequence=VSP_059571;
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB36854.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAB78432.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AL035528; CAB36854.1; ALT_INIT; Genomic_DNA.
DR EMBL; AL161537; CAB78432.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002687; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BT000466; AAN17443.1; -; mRNA.
DR EMBL; AK221537; BAD94878.1; -; mRNA.
DR PIR; T05259; T05259.
DR AlphaFoldDB; Q9SVM3; -.
DR SMR; Q9SVM3; -.
DR PeptideAtlas; Q9SVM3; -.
DR PRIDE; Q9SVM3; -.
DR Araport; AT4G13900; -.
DR PRO; PR:Q9SVM3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q9SVM3; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 4.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 3.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 7.
DR PROSITE; PS51450; LRR; 15.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Leucine-rich repeat;
KW Membrane; Receptor; Reference proteome; Repeat; Signal; Transmembrane;
KW Transmembrane helix.
FT SIGNAL 1..31
FT /evidence="ECO:0000255"
FT CHAIN 32..844
FT /note="Receptor-like protein 49"
FT /id="PRO_5010148786"
FT TOPO_DOM 32..803
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 804..824
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 825..844
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 102..126
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 136..160
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 161..183
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 185..208
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 209..231
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 242..265
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 266..290
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 292..313
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 315..339
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 345..362
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 363..385
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 386..409
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 410..434
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 436..457
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 458..481
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 482..504
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 506..527
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 528..551
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 553..574
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 575..601
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 602..625
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 665..689
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 690..713
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 714..737
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 739..762
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT CARBOHYD 59
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 95
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 112
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 207
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 262
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 310
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 374
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 384
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 416
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 493
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 516
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 550
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 696
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 712
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 744
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 257..349
FT /note="Missing (in isoform 2)"
FT /id="VSP_059571"
SQ SEQUENCE 844 AA; 93910 MW; D7E0BABD2C965705 CRC64;
MMYSCRERRM ITVKWSLCLI FCLSNSILVF AKHLCLPDQR DSLWGFKNEF HVPSEKWRNN
TDCCSWDGVS CDPKTGNVVG LDLAGSDLNG PLRSNSSLFR LQHLQKLYLG CNTSFGSLSY
NDGLKGGELL DSIGNLKYLK VLSLRGCNLF GKIPSSLGNL SYLTHLDLSF NDFTGVIPDS
MGNLNYLRVL NLGKCNFYGK VPSSLGNLSY LAQLDLSYND FTREGPDSMG NLNRLTDMLL
KLNSLTDIDL GSNQLKGMLP SNMSSLSKLE YFYIGGNSFS GSIPSSLFMI PSLVELDLQR
NHFSALEIGN ISSQSKLQVL ILGGNNFNPD IVDLSIFSPL LSLGYLDVSG INLKISSTVS
LPSPIEYLVL SSCNISEFPK FLRNQTKLYS LDISANQIEG QVPEWLWSLP ELQSINISHN
SFNGFEGPAD VIQGGGELYM LDISSNIFQD PFPLLPVDSM NFLFSSNNRF SGEIPKTICE
LDNLVMLVLS NNNFSGSIPR CFENLHLYVL HLRNNNLSGI FPEEAISDRL QSLDVGHNLF
SGELPKSLIN CSALEFLYVE DNRISDTFPS WLELLPNFQI LVLRSNEFYG PIFSPGDSLS
FPRLRIFDIS ENRFTGVLPS DYFAPWSAMS SVVDRIIQHF FQGYYHNSVV LTNKGLNMEL
VGSGFTIYKT IDVSGNRLEG DIPESISLLK ELIVLNMSNN AFTGHIPPSL SNLSNLQSLD
LSQNRLSGSI PGELGELTFL ARMNFSYNRL EGPIPQTTQI QTQDSSSFTE NPGLCGLPLK
KNCGGKEEAT KQEQDEEKEE EEQVFSWIAA AIGYVPGVVC GLTIGHILVS HKRDWFMRIV
SLFT
