RLP50_ARATH
ID RLP50_ARATH Reviewed; 891 AA.
AC Q93YT3; O23253;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Receptor-like protein 50 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP50 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP50 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At4g13920 {ECO:0000312|Araport:AT4G13920};
GN ORFNames=Dl3000W {ECO:0000312|EMBL:CAB10171.1},
GN FCAALL.223 {ECO:0000312|EMBL:CAB78434.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=9461215; DOI=10.1038/35140;
RA Bevan M., Bancroft I., Bent E., Love K., Goodman H.M., Dean C.,
RA Bergkamp R., Dirkse W., van Staveren M., Stiekema W., Drost L., Ridley P.,
RA Hudson S.-A., Patel K., Murphy G., Piffanelli P., Wedler H., Wedler E.,
RA Wambutt R., Weitzenegger T., Pohl T., Terryn N., Gielen J., Villarroel R.,
RA De Clercq R., van Montagu M., Lecharny A., Aubourg S., Gy I., Kreis M.,
RA Lao N., Kavanagh T., Hempel S., Kotter P., Entian K.-D., Rieger M.,
RA Schaefer M., Funk B., Mueller-Auer S., Silvey M., James R., Monfort A.,
RA Pons A., Puigdomenech P., Douka A., Voukelatou E., Milioni D.,
RA Hatzopoulos P., Piravandi E., Obermaier B., Hilbert H., Duesterhoeft A.,
RA Moores T., Jones J.D.G., Eneva T., Palme K., Benes V., Rechmann S.,
RA Ansorge W., Cooke R., Berger C., Delseny M., Voet M., Volckaert G.,
RA Mewes H.-W., Klosterman S., Schueller C., Chalwatzis N.;
RT "Analysis of 1.9 Mb of contiguous sequence from chromosome 4 of Arabidopsis
RT thaliana.";
RL Nature 391:485-488(1998).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617198; DOI=10.1038/47134;
RA Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA Martienssen R., McCombie W.R.;
RT "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL Nature 402:769-777(1999).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAB10171.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=CAB78434.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; Z97335; CAB10171.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AL161537; CAB78434.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002687; AEE83343.1; -; Genomic_DNA.
DR EMBL; AY059776; AAL24124.1; -; mRNA.
DR EMBL; AY091445; AAM14384.1; -; mRNA.
DR PIR; A71400; A71400.
DR RefSeq; NP_567412.1; NM_117466.2.
DR AlphaFoldDB; Q93YT3; -.
DR SMR; Q93YT3; -.
DR STRING; 3702.AT4G13920.1; -.
DR PaxDb; Q93YT3; -.
DR PRIDE; Q93YT3; -.
DR ProteomicsDB; 228109; -.
DR EnsemblPlants; AT4G13920.1; AT4G13920.1; AT4G13920.
DR GeneID; 827026; -.
DR Gramene; AT4G13920.1; AT4G13920.1; AT4G13920.
DR KEGG; ath:AT4G13920; -.
DR Araport; AT4G13920; -.
DR TAIR; locus:2129246; AT4G13920.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; Q93YT3; -.
DR OMA; NAFREPF; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q93YT3; -.
DR PRO; PR:Q93YT3; -.
DR Proteomes; UP000006548; Chromosome 4.
DR ExpressionAtlas; Q93YT3; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 3.
DR Pfam; PF13516; LRR_6; 3.
DR Pfam; PF13855; LRR_8; 4.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 6.
DR PROSITE; PS51450; LRR; 16.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Receptor;
KW Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..891
FT /note="Receptor-like protein 50"
FT /id="PRO_5011950530"
FT TOPO_DOM 23..849
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 850..870
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 871..891
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 105..130
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 132..152
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 153..176
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 177..201
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 203..225
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 226..249
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 250..272
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 286..309
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 310..334
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 336..358
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 359..383
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 384..407
FT /note="LRR 12; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 408..436
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 438..453
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 454..477
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 478..504
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 506..519
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 520..544
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 545..568
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 570..591
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 593..614
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 615..641
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 642..665
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 712..736
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 737..760
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 761..784
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 786..809
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT CARBOHYD 62
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 98
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 200
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 251
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 285
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 306
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 355
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 442
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 452
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 531
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 544
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 554
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 590
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 605
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 743
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 759
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 791
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 811
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 891 AA; 98334 MW; A3B8C572C7B3B582 CRC64;
MITIIWSLCL IFCLSNSILV IAKDLCLPDQ RDALLEFKNE FSIPSPDSDL MLILQTTAKW
RNNTDCCSWG GISCDPKTGV VVELDLGNSD LNGRLRSNSS LFRLQHLQSL DLSYNDLSCT
LPDSSGNFKY LRVLNLLGCN LFGEIPTSLR SLSYLTDLDL SYNDDLTGEI LDSMGNLKHL
RVLSLTSCKF TGKIPSSLGN LTYLTDLDLS WNYFTGELPD SMGNLKSLRV LNLHRCNFFG
KIPTSLGSLS NLTDLDISKN EFTSEGPDSM SSLNRLTDFQ LMLLNLSSLT NVDLSSNQFK
AMLPSNMSSL SKLEAFDISG NSFSGTIPSS LFMLPSLIKL DLGTNDFSGP LKIGNISSPS
NLQELYIGEN NINGPIPRSI LKLVGLSALS LSFWDTGGIV DFSIFLQLKS LRSLDLSGIN
LNISSSHHLP SHMMHLILSS CNISQFPKFL ENQTSLYHLD ISANQIEGQV PEWLWRLPTL
RYVNIAQNAF SGELTMLPNP IYSFIASDNK FSGEIPRAVC EIGTLVLSNN NFSGSIPPCF
EISNKTLSIL HLRNNSLSGV IPEESLHGYL RSLDVGSNRL SGQFPKSLIN CSYLQFLNVE
ENRINDTFPS WLKSLPNLQL LVLRSNEFHG PIFSPGDSLS FSKLRFFDIS ENRFSGVLPS
DYFVGWSVMS SFVDIIDNTP GFTVVGDDQE SFHKSVVLTI KGLNMELVGS GFEIYKTIDV
SGNRLEGDIP ESIGILKELI VLNMSNNAFT GHIPPSLSNL SNLQSLDLSQ NRLSGSIPGE
LGELTFLARM NFSYNMLEGP IPQGTQIQSQ NSSSFAENPG LCGAPLQKKC GGEEEEDKEK
EEKDKGLSWV AAAIGYVPGL FCGLAIGHIL TSYKRDWFMR IFSCFSSPLK K
