RLP52_ARATH
ID RLP52_ARATH Reviewed; 811 AA.
AC Q7FZR1; Q8GUJ4;
DT 23-MAY-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 141.
DE RecName: Full=Receptor-like protein 52 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP52 {ECO:0000303|PubMed:18434605};
DE Flags: Precursor;
GN Name=RLP52 {ECO:0000303|PubMed:18434605};
GN OrderedLocusNames=At5g25910 {ECO:0000312|Araport:AT5G25910};
GN ORFNames=T1N24.21 {ECO:0000312|EMBL:AAD40136.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130714; DOI=10.1038/35048507;
RA Tabata S., Kaneko T., Nakamura Y., Kotani H., Kato T., Asamizu E.,
RA Miyajima N., Sasamoto S., Kimura T., Hosouchi T., Kawashima K., Kohara M.,
RA Matsumoto M., Matsuno A., Muraki A., Nakayama S., Nakazaki N., Naruo K.,
RA Okumura S., Shinpo S., Takeuchi C., Wada T., Watanabe A., Yamada M.,
RA Yasuda M., Sato S., de la Bastide M., Huang E., Spiegel L., Gnoj L.,
RA O'Shaughnessy A., Preston R., Habermann K., Murray J., Johnson D.,
RA Rohlfing T., Nelson J., Stoneking T., Pepin K., Spieth J., Sekhon M.,
RA Armstrong J., Becker M., Belter E., Cordum H., Cordes M., Courtney L.,
RA Courtney W., Dante M., Du H., Edwards J., Fryman J., Haakensen B.,
RA Lamar E., Latreille P., Leonard S., Meyer R., Mulvaney E., Ozersky P.,
RA Riley A., Strowmatt C., Wagner-McPherson C., Wollam A., Yoakum M., Bell M.,
RA Dedhia N., Parnell L., Shah R., Rodriguez M., Hoon See L., Vil D.,
RA Baker J., Kirchoff K., Toth K., King L., Bahret A., Miller B., Marra M.A.,
RA Martienssen R., McCombie W.R., Wilson R.K., Murphy G., Bancroft I.,
RA Volckaert G., Wambutt R., Duesterhoeft A., Stiekema W., Pohl T.,
RA Entian K.-D., Terryn N., Hartley N., Bent E., Johnson S., Langham S.-A.,
RA McCullagh B., Robben J., Grymonprez B., Zimmermann W., Ramsperger U.,
RA Wedler H., Balke K., Wedler E., Peters S., van Staveren M., Dirkse W.,
RA Mooijman P., Klein Lankhorst R., Weitzenegger T., Bothe G., Rose M.,
RA Hauf J., Berneiser S., Hempel S., Feldpausch M., Lamberth S.,
RA Villarroel R., Gielen J., Ardiles W., Bents O., Lemcke K., Kolesov G.,
RA Mayer K.F.X., Rudd S., Schoof H., Schueller C., Zaccaria P., Mewes H.-W.,
RA Bevan M., Fransz P.F.;
RT "Sequence and analysis of chromosome 5 of the plant Arabidopsis thaliana.";
RL Nature 408:823-826(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [5]
RP FUNCTION, INDUCTION BY CHITIN, AND DISRUPTION PHENOTYPE.
RX PubMed=15923325; DOI=10.1104/pp.105.060947;
RA Ramonell K., Berrocal-Lobo M., Koh S., Wan J., Edwards H., Stacey G.,
RA Somerville S.;
RT "Loss-of-function mutations in chitin responsive genes show increased
RT susceptibility to the powdery mildew pathogen Erysiphe cichoracearum.";
RL Plant Physiol. 138:1027-1036(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RC STRAIN=cv. Columbia;
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- FUNCTION: Required for defense against powdery mildew pathogen.
CC {ECO:0000269|PubMed:15923325}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q7FZR1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q7FZR1-2; Sequence=VSP_059572, VSP_059573;
CC -!- INDUCTION: By chitin. {ECO:0000269|PubMed:15923325}.
CC -!- DISRUPTION PHENOTYPE: Enhanced susceptibility to pathogen powdery
CC mildew E.cichoracearum. {ECO:0000269|PubMed:15923325}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
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DR EMBL; AF149413; AAD40136.1; -; Genomic_DNA.
DR EMBL; CP002688; AED93500.1; -; Genomic_DNA.
DR EMBL; BT002464; AAO00824.1; -; mRNA.
DR EMBL; BT009659; AAP75809.1; -; mRNA.
DR RefSeq; NP_197963.1; NM_122492.1. [Q7FZR1-1]
DR AlphaFoldDB; Q7FZR1; -.
DR SMR; Q7FZR1; -.
DR STRING; 3702.AT5G25910.1; -.
DR iPTMnet; Q7FZR1; -.
DR PaxDb; Q7FZR1; -.
DR PRIDE; Q7FZR1; -.
DR EnsemblPlants; AT5G25910.1; AT5G25910.1; AT5G25910. [Q7FZR1-1]
DR GeneID; 832660; -.
DR Gramene; AT5G25910.1; AT5G25910.1; AT5G25910. [Q7FZR1-1]
DR KEGG; ath:AT5G25910; -.
DR Araport; AT5G25910; -.
DR TAIR; locus:2180587; AT5G25910.
DR eggNOG; KOG0619; Eukaryota.
DR HOGENOM; CLU_000288_18_3_1; -.
DR InParanoid; Q7FZR1; -.
DR OMA; LTTDMIQ; -.
DR OrthoDB; 826997at2759; -.
DR PhylomeDB; Q7FZR1; -.
DR PRO; PR:Q7FZR1; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q7FZR1; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0050832; P:defense response to fungus; IMP:TAIR.
DR GO; GO:0010200; P:response to chitin; IEP:TAIR.
DR Gene3D; 3.80.10.10; -; 3.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR InterPro; IPR045273; RLP23-like.
DR PANTHER; PTHR27004; PTHR27004; 5.
DR Pfam; PF13855; LRR_8; 3.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Glycoprotein; Leucine-rich repeat;
KW Membrane; Plant defense; Receptor; Reference proteome; Repeat; Signal;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..811
FT /note="Receptor-like protein 52"
FT /id="PRO_5011948720"
FT TOPO_DOM 23..770
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 771..791
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 792..811
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 62..86
FT /note="LRR 1"
FT /evidence="ECO:0000255"
FT REPEAT 87..110
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 112..134
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 135..159
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 161..183
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 184..208
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 211..233
FT /note="LRR 7; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 234..258
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 260..281
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 282..305
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 307..329
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 330..354
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 356..377
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 379..401
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 403..427
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 441..465
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 466..489
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 491..511
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 512..537
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 539..557
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 558..581
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 625..649
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 650..673
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 674..697
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 699..722
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT CARBOHYD 47
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 64
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 74
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 93
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 109
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 233
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 246
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 260
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 304
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 389
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 422
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 429
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 455
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 464
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 485
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 525
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 571
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 581
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 656
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 704
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT VAR_SEQ 426..448
FT /note="SNNNFTGKIPSFICELHSLILLD -> ESFEQHFHRFQKINEIYRATIYE
FT (in isoform 2)"
FT /id="VSP_059572"
FT VAR_SEQ 449..811
FT /note="Missing (in isoform 2)"
FT /id="VSP_059573"
SQ SEQUENCE 811 AA; 90357 MW; D10130CEB36FF346 CRC64;
MTFLPLLFIF FFLTSIPFPA FSQYNDRSTL LNLKRDLGDP LSLRLWNDTS SPCNWPRITC
TAGNVTEINF QNQNFTGTVP TTICNFPNLK SLNLSFNYFA GEFPTVLYNC TKLQYLDLSQ
NLFNGSLPDD INRLAPKLKY LDLAANSFAG DIPKNIGRIS KLKVLNLYMS EYDGTFPSEI
GDLSELEELQ LALNDKFTPV KLPTEFGKLK KLKYMWLEEM NLIGEISAVV FENMTDLKHV
DLSVNNLTGR IPDVLFGLKN LTELYLFAND LTGEIPKSIS AKNLVHLDLS ANNLNGSIPE
SIGNLTNLEL LYLFVNELTG EIPRAIGKLP ELKELKLFTN KLTGEIPAEI GFISKLERFE
VSENQLTGKL PENLCHGGKL QSVIVYSNNL TGEIPESLGD CETLSSVLLQ NNGFSGSVTI
SNNTRSNNNF TGKIPSFICE LHSLILLDLS TNKFNGSIPR CIANLSTLEV LNLGKNHLSG
SIPENISTSV KSIDIGHNQL AGKLPRSLVR ISSLEVLNVE SNKINDTFPF WLDSMQQLQV
LVLRSNAFHG SINQNGFSKL RIIDISGNHF NGTLPLDFFV NWTAMFSLGK IEDQYMGTNY
MRTNYYSDSI VVMIKGIALE MVRILNTFTT IDFSGNKFEG EIPRSVGLLK ELHVLNLSNN
GFTGHIPSSM GNLIELESLD VSQNKLSGEI PPELGKLSYL AYMNFSQNQF VGLVPGGTQF
QTQPCSSFAD NPRLFGLSLE RVCVDIHKKT PQQSEMPEPE EDEEEVMNWT AAAIGSIPGI
SIGLTMGYIL VSYKPEWLMN SGRNKRRIKP I
