RLP8_ARATH
ID RLP8_ARATH Reviewed; 1044 AA.
AC Q70CT4; A0A178W4L1;
DT 28-FEB-2018, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Receptor-like protein 8 {ECO:0000303|PubMed:18434605};
DE Short=AtRLP8 {ECO:0000303|PubMed:18434605};
DE AltName: Full=RESISTANCE TO PERONOSPORA PARASITICA 27 {ECO:0000312|EMBL:CAE51863.1, ECO:0000312|EMBL:CAE51864.1};
DE Flags: Precursor;
GN Name=RLP8 {ECO:0000303|PubMed:18434605};
GN Synonyms=RPP27 {ECO:0000312|EMBL:CAE51863.1, ECO:0000312|EMBL:CAE51864.1};
GN OrderedLocusNames=AXX17_At1g48960 {ECO:0000312|EMBL:OAP12052.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA], AND RETRACTED PAPER.
RC STRAIN=cv. Landsberg erecta;
RX PubMed=15155873; DOI=10.1104/pp.103.037770;
RA Tor M., Brown D., Cooper A., Woods-Tor A., Sjolender K., Jones J.J.,
RA Holub E.;
RT "Arabidopsis downy mildew resistance gene RPP27 encodes a receptor-like
RT protein similar to CLAVATA2 and tomato Cf-9.";
RL Plant Physiol. 135:1100-1112(2004).
RN [2]
RP ERRATUM OF PUBMED:15155873, RETRACTION NOTICE OF PUBMED:15155873, AND
RP CAUTION.
RX PubMed=17284584; DOI=10.1104/pp.104.900215;
RA Toer M., Brown D., Cooper A., Woods-Tor A., Sjolander K., Jones J.D.G.,
RA Holub E.B.;
RL Plant Physiol. 143:1079-1079(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Landsberg erecta;
RX PubMed=27354520; DOI=10.1073/pnas.1607532113;
RA Zapata L., Ding J., Willing E.M., Hartwig B., Bezdan D., Jiao W.B.,
RA Patel V., Velikkakam James G., Koornneef M., Ossowski S., Schneeberger K.;
RT "Chromosome-level assembly of Arabidopsis thaliana Ler reveals the extent
RT of translocation and inversion polymorphisms.";
RL Proc. Natl. Acad. Sci. U.S.A. 113:E4052-E4060(2016).
RN [4]
RP REVIEW.
RX PubMed=20565641; DOI=10.1111/j.1364-3703.2004.00264.x;
RA Kruijt M., de Kock M.J., de Wit P.J.;
RT "Receptor-like proteins involved in plant disease resistance.";
RL Mol. Plant Pathol. 6:85-97(2005).
RN [5]
RP GENE FAMILY.
RX PubMed=15955925; DOI=10.1104/pp.104.054452;
RA Fritz-Laylin L.K., Krishnamurthy N., Toer M., Sjoelander K.V., Jones J.D.;
RT "Phylogenomic analysis of the receptor-like proteins of rice and
RT Arabidopsis.";
RL Plant Physiol. 138:611-623(2005).
RN [6]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=18434605; DOI=10.1104/pp.108.119487;
RA Wang G., Ellendorff U., Kemp B., Mansfield J.W., Forsyth A., Mitchell K.,
RA Bastas K., Liu C.-M., Woods-Toer A., Zipfel C., de Wit P.J.G.M.,
RA Jones J.D.G., Toer M., Thomma B.P.H.J.;
RT "A genome-wide functional investigation into the roles of receptor-like
RT proteins in Arabidopsis.";
RL Plant Physiol. 147:503-517(2008).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Single-pass type I
CC membrane protein {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the RLP family. {ECO:0000305}.
CC -!- CAUTION: In strain cv. Columbia (AC Q9SLI6), a naturally occurring
CC variation results in the deletion of 35 amino acids in the middle part
CC of the protein. The sequence shown is from strain cv. Landsberg erecta.
CC {ECO:0000305}.
CC -!- CAUTION: Was originally thought to be involved in Peronospora
CC parasitica resistance (PubMed:15155873). However, the corresponding
CC article has been retracted (PubMed:17284584).
CC {ECO:0000269|PubMed:15155873, ECO:0000269|PubMed:17284584}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AJ585978; CAE51863.1; -; Genomic_DNA.
DR EMBL; AJ585979; CAE51864.1; -; mRNA.
DR EMBL; LUHQ01000001; OAP12052.1; -; Genomic_DNA.
DR AlphaFoldDB; Q70CT4; -.
DR SMR; Q70CT4; -.
DR Proteomes; UP000078284; Chromosome 1.
DR ExpressionAtlas; Q70CT4; baseline and differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR Gene3D; 3.80.10.10; -; 5.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR013210; LRR_N_plant-typ.
DR Pfam; PF00560; LRR_1; 1.
DR Pfam; PF13855; LRR_8; 1.
DR Pfam; PF08263; LRRNT_2; 1.
DR SMART; SM00369; LRR_TYP; 8.
DR PROSITE; PS51450; LRR; 17.
PE 2: Evidence at transcript level;
KW Cell membrane; Glycoprotein; Leucine-rich repeat; Membrane; Receptor;
KW Repeat; Signal; Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..1044
FT /note="Receptor-like protein 8"
FT /id="PRO_5010143093"
FT TOPO_DOM 23..996
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 997..1017
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 1018..1044
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REPEAT 204..231
FT /note="LRR 1; degenerate"
FT /evidence="ECO:0000305"
FT REPEAT 232..255
FT /note="LRR 2"
FT /evidence="ECO:0000255"
FT REPEAT 257..281
FT /note="LRR 3"
FT /evidence="ECO:0000255"
FT REPEAT 282..305
FT /note="LRR 4"
FT /evidence="ECO:0000255"
FT REPEAT 306..329
FT /note="LRR 5"
FT /evidence="ECO:0000255"
FT REPEAT 331..354
FT /note="LRR 6"
FT /evidence="ECO:0000255"
FT REPEAT 355..377
FT /note="LRR 7"
FT /evidence="ECO:0000255"
FT REPEAT 379..402
FT /note="LRR 8"
FT /evidence="ECO:0000255"
FT REPEAT 404..427
FT /note="LRR 9"
FT /evidence="ECO:0000255"
FT REPEAT 429..452
FT /note="LRR 10"
FT /evidence="ECO:0000255"
FT REPEAT 453..476
FT /note="LRR 11"
FT /evidence="ECO:0000255"
FT REPEAT 478..500
FT /note="LRR 12"
FT /evidence="ECO:0000255"
FT REPEAT 501..525
FT /note="LRR 13"
FT /evidence="ECO:0000255"
FT REPEAT 527..549
FT /note="LRR 14"
FT /evidence="ECO:0000255"
FT REPEAT 550..573
FT /note="LRR 15"
FT /evidence="ECO:0000255"
FT REPEAT 575..600
FT /note="LRR 16"
FT /evidence="ECO:0000255"
FT REPEAT 602..622
FT /note="LRR 17"
FT /evidence="ECO:0000255"
FT REPEAT 623..647
FT /note="LRR 18"
FT /evidence="ECO:0000255"
FT REPEAT 648..671
FT /note="LRR 19"
FT /evidence="ECO:0000255"
FT REPEAT 673..695
FT /note="LRR 20"
FT /evidence="ECO:0000255"
FT REPEAT 697..716
FT /note="LRR 21"
FT /evidence="ECO:0000255"
FT REPEAT 717..740
FT /note="LRR 22"
FT /evidence="ECO:0000255"
FT REPEAT 742..763
FT /note="LRR 23"
FT /evidence="ECO:0000255"
FT REPEAT 764..787
FT /note="LRR 24"
FT /evidence="ECO:0000255"
FT REPEAT 854..877
FT /note="LRR 25"
FT /evidence="ECO:0000255"
FT REPEAT 878..901
FT /note="LRR 26"
FT /evidence="ECO:0000255"
FT REPEAT 902..926
FT /note="LRR 27"
FT /evidence="ECO:0000255"
FT REPEAT 928..951
FT /note="LRR 28"
FT /evidence="ECO:0000255"
FT REGION 969..990
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 197
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 267
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 390
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 402
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 532
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 551
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 561
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 586
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 623
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 646
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 751
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 786
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 885
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 925
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 938
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
FT CARBOHYD 969
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00498"
SQ SEQUENCE 1044 AA; 116826 MW; 3E0568AF7FDC5A64 CRC64;
MKTNFVILLL LLCVFAISPS QQEEINQHNP GIYHQKLLYK VQQWRTSLKE SNSVELKLSL
AAIVAGVLYF LAALISSACG IGSGGLFIPI TTLVSRLDLK TGKRFLGQYL IWVILLLGQL
HECKSCIEKE RVALLDFKKY WMSITQESDL DYVFPTWNND TKSDCCQWES IMCNPTSGRL
IRLHVGASNL KENSLLNISL LHPFEEVRSL ELSAGLNGFV DNVEGYKSLR KLKNLEILDL
SYNNRFNNNI LPFINAATSL TSLSLQNNSM EGPFPFEEIK DLTNLKLLDL SRNILKGPMQ
GLTHLKKLKA LDLSNNVFSS IMELQVVCEM KNLWELDLRE NKFVGQLPLC LGRLNKLRVL
DLSSNQLNGN LPSTFNRLES LEYLSLLDNN FTGFFSFDPL ANLTKLKVFK LSSTSDMLQI
KTESEPKYQF QLSVVVIRVC SLEKIPSFLE YQKNLRLVDL SNNRLSGNLP TWLLANNPEL
KVLQLQDNLF TIFQMPATIV HELQFLDFSV NDISGLLPDN IGYALPNLLR MNGSRNGFQG
HLPSSMGEMV NITSLDLSYN NFSGKLPRRF VTGCFSLKHL KLSHNNFSGH FLPRETSFTS
LEELRVDSNS FTGKIGVGLL SSNTTLSVLD MSNNFLTGDI PSWMSNLSGL TILSISNNFL
EGTIPPSLLA IGFLSLIDLS GNLLSGSLPS RVGGEFGIKL FLHDNMLTGP IPDTLLEKVQ
ILDLRYNQLS GSIPQFVNTE SIYILLMKGN NLTGSMSRQL CDLRNIRLLD LSDNKLNGFI
PSCLYNLSFG PEDTNSYVGT AITKITPFKF YESTFVVEDF VVISSSFQEI EIKFSMKRRY
DSYFGATEFN NDVLDYMYGM DLSSNELSGV IPAELGSLSK LRVMNLSCNF LSSSIPSSFS
NLKDIESLDL SHNMLQGSIP QQLTNLSSLV VFDVSYNNLS GIIPQGRQFN TFDEKSYLGN
PLLCGPPTNR SCDAKKTSDE SENGGEEEDD EAPVDMLAFY FSSASTYVTT LIGIFILMCF
DCPLRRAWLR IVDASIASVK SMLP
