ID   RLPA_RICCN              Reviewed;         320 AA.
AC   Q92I83;
DT   05-MAR-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-DEC-2001, sequence version 1.
DT   25-MAY-2022, entry version 93.
DE   RecName: Full=Endolytic peptidoglycan transglycosylase RlpA {ECO:0000255|HAMAP-Rule:MF_02071};
DE            EC=4.2.2.- {ECO:0000255|HAMAP-Rule:MF_02071};
GN   Name=rlpA {ECO:0000255|HAMAP-Rule:MF_02071}; OrderedLocusNames=RC0537;
OS   Rickettsia conorii (strain ATCC VR-613 / Malish 7).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rickettsiales;
OC   Rickettsiaceae; Rickettsieae; Rickettsia; spotted fever group.
OX   NCBI_TaxID=272944;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC VR-613 / Malish 7;
RX   PubMed=11557893; DOI=10.1126/science.1061471;
RA   Ogata H., Audic S., Renesto-Audiffren P., Fournier P.-E., Barbe V.,
RA   Samson D., Roux V., Cossart P., Weissenbach J., Claverie J.-M., Raoult D.;
RT   "Mechanisms of evolution in Rickettsia conorii and R. prowazekii.";
RL   Science 293:2093-2098(2001).
CC   -!- FUNCTION: Lytic transglycosylase with a strong preference for naked
CC       glycan strands that lack stem peptides. {ECO:0000255|HAMAP-
CC       Rule:MF_02071}.
CC   -!- SIMILARITY: Belongs to the RlpA family. {ECO:0000255|HAMAP-
CC       Rule:MF_02071}.
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DR   EMBL; AE006914; AAL03075.1; -; Genomic_DNA.
DR   PIR; A97767; A97767.
DR   RefSeq; WP_010977174.1; NC_003103.1.
DR   AlphaFoldDB; Q92I83; -.
DR   SMR; Q92I83; -.
DR   EnsemblBacteria; AAL03075; AAL03075; RC0537.
DR   KEGG; rco:RC0537; -.
DR   PATRIC; fig|272944.4.peg.616; -.
DR   HOGENOM; CLU_042923_6_1_5; -.
DR   OMA; GKTYKPH; -.
DR   Proteomes; UP000000816; Chromosome.
DR   GO; GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
DR   GO; GO:0008932; F:lytic endotransglycosylase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0071555; P:cell wall organization; IEA:UniProtKB-KW.
DR   GO; GO:0000270; P:peptidoglycan metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 2.40.40.10; -; 1.
DR   HAMAP; MF_02071; RlpA; 1.
DR   InterPro; IPR005728; Rickett_RPE.
DR   InterPro; IPR034718; RlpA.
DR   InterPro; IPR009009; RlpA-like_DPBB.
DR   InterPro; IPR036908; RlpA-like_sf.
DR   InterPro; IPR022438; RPE5.
DR   InterPro; IPR012997; RplA.
DR   Pfam; PF03330; DPBB_1; 1.
DR   SUPFAM; SSF50685; SSF50685; 1.
DR   TIGRFAMs; TIGR00413; rlpA; 1.
DR   TIGRFAMs; TIGR01045; RPE1; 1.
DR   TIGRFAMs; TIGR03776; RPE5; 1.
PE   3: Inferred from homology;
KW   Cell wall biogenesis/degradation; Lyase.
FT   CHAIN           1..320
FT                   /note="Endolytic peptidoglycan transglycosylase RlpA"
FT                   /id="PRO_0000190005"
FT   REGION          12..59
FT                   /note="REP05 insert 1"
FT   REGION          62..74
FT                   /note="REP07 insert"
FT   REGION          89..98
FT                   /note="REP05 insert 2"
SQ   SEQUENCE   320 AA;  36122 MW;  00BA6C6E89CFFAB2 CRC64;
     MIIVKNHKFK LDLLQNEANK EKFEGNTACS TAAYTLVRED ASTGLTYTAD ISKVGNQISG
     EPAQRIKIRE HRRIPKFDLP NLKVSKVYKL PLEASYAKGL LLLLIFCFGL SGCNTSKRLP
     YSHKYSYKEL SKDDPHNLTY KGHYKVGKNY KIKGKTYKPH NPKSFTETGY ASWYGGLKDG
     FHGKKTANGD RFNRNLLTAA HKTLPLPCLV KVTNKANNKA VILMVNDRGP FKKNRIIDVS
     QRAAEILAFK NQGITKVKIE YLPNETEKFL KNINLKKPQS KTLAKNSKKS SSNKVTNNNK
     CSVNCHIKLI NLKYKLAVTP